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Influence of geneti...
Influence of genetic background and oxidative stress response on risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer
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- Danielsson, Daniel (author)
- Karolinska Institutet
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- Brehwens, Karl (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Halle, Martin (author)
- Karolinska Institutet
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Marczyk, Michal (author)
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- Sollazzo, Alice (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Polanska, Joanna (author)
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- Munck-Wikland, Eva (author)
- Karolinska Institutet
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- Wojcik, Andrzej (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Jan Kochanowski University, Poland
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- Haghdoost, Siamak (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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(creator_code:org_t)
- 2015-05-26
- 2016
- English.
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In: Head and Neck. - : Wiley. - 1043-3074 .- 1097-0347. ; 38:3, s. 387-393
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Osteoradionecrosis (ORN) of the mandible is a severe complication of head and neck radiotherapy (RT) treatment, where the impact of individual radiosensitivity has been a suggested explanation. Methods: A cohort of patients with stage II/III ORN was compared to matched controls. Blood was collected and irradiated in vitro to study the capacity to handle radiation-induced oxidative stress. Patients were also genotyped for 8 single-nucleotide polymorphisms (SNPs) in genes involved in the oxidative stress response. Results: A difference in 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxo-dG) levels was found between the patient cohorts (p = 0.01). The SNP rs1695 in glutathione s-transferase p1 (GSTP1) was also found to be more frequent in the patients with ORN (p = .02). Multivariate analysis of the clinical and biological factors revealed concomitant brachytherapy plus the 2 biomarkers to be significant factors which influense risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer. Conclusion: The current study indicates that oxidative stress response contributes to individual radiosensitivity and healthy tissue damage caused by RT and may be predicted by biomarker analysis.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- serum 8-oxo-7
- 8-dihydro-2 '-deoxyguanosine (8-oxo-dG)
- glutathione s-transferase p1 (GSTP1) mutation
- oxidative stress
- radiotherapy
- rs 1695
- head and neck
- osteoradionecrosis
- molekylär biovetenskap
- Molecular Bioscience
Publication and Content Type
- ref (subject category)
- art (subject category)
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