Binuclear ruthenium(II) phenanthroline compounds with extreme binding affinity for DNA

• Dimeric homochiral ruthenium complexes [L(2)Ru{dppz(11-11')dppz}RuL(2)](4+) (L = 1,10-phenanthroline, 2,2'-bipyridyl; dppz = dipyrido[3,2-A:2',3'-C]phenazine) bind extremely strongly to duplex DNA with different binding geometries for the Delta Delta and Lambda Lambda enantiomers of the phenanthroline complex but with similar geometries for the bipyridyl complex enantiomers.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

transition-metal complexes

nucleic-acids

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