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Emotional dysregula...
Emotional dysregulation and stimulant medication in adult ADHD
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- Greenfield, Myrto Sklivanioti (författare)
- Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
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- Wang, Yanlu (författare)
- Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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- Hamilton, J. Paul (författare)
- Department of Biological and Medical Psychology, University of Bergen, Norway
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- Thunberg, Per, 1968- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department for Radiology and Medical Physics; Center for Experimental and Biomedical Imaging
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- Msghina, Mussie, 1959- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Psychiatry
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(creator_code:org_t)
- Ovid, 2024
- 2024
- Engelska.
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Ingår i: Journal of Psychiatry & Neuroscience. - : Ovid. - 1180-4882 .- 1488-2434. ; 49:4, s. E242-E251
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Emotional dysregulation affects up to two-thirds of adult patients with attention-deficit/hyperactivity disorder (ADHD) and is increasingly seen as a core ADHD symptom that is clinically associated with greater functional impairment and psychiatric comorbidity. We sought to investigate emotional dysregulation in ADHD and explored its neural underpinnings.Methods: We studied emotion induction and regulation in a clinical cohort of adult patients with ADHD before and after a stimulant challenge. We compared patients with age- and gender-matched healthy controls using behavioural, structural, and functional measures. We hypothesized that patients would demonstrate aberrant emotion processing compared with healthy controls, and sought to find whether this could be normalized by stimulant medication.Results: Behaviourally, the ADHD group showed reduced emotion induction and regulation capacity. Brain imaging revealed abberant activation and deactivation patterns during emotion regulation, lower grey-matter volume in limbic and paralimbic areas, and greater grey-matter volume in visual and cerebellar areas, compared with healthy controls. The behavioural and functional deficits seen in emotion induction and regulation in the ADHD group were not normalized by stimulant medication.Conclusion: Patients with ADHD may have impaired emotion induction and emotion regulation capacity, but these deficits are not reversed by stimulant medication. These results have important clinical implications when assessing which aspects of emotional dysregulation are relevant for patients and if and how traditional ADHD pharmacotherapy affects emotion induction and emotion regulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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