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Anti-cyclic citrull...
Anti-cyclic citrullinated peptide antibodies, other common autoantibodies, and smoking as risk factors for lymphoma in patients with rheumatoid arthritis
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- Baecklund, Eva, 1956- (author)
- Uppsala universitet,Reumatologi
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- Backlin, Carin (author)
- Uppsala universitet,Reumatologi
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- Rönnelid, Johan (author)
- Uppsala universitet,Klinisk immunologi
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Toes, R (author)
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Huizinga, Twj (author)
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- Åhlin, Erik, 1980- (author)
- Uppsala universitet,Klinisk immunologi
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- Askling, J (author)
- Karolinska Institutet
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Hochberg, F H (author)
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- Klareskog, L (author)
- Karolinska Institutet
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Kay, J (author)
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- Smedby, K E (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-01-16
- 2018
- English.
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In: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 0300-9742 .- 1502-7732. ; 47:4, s. 270-275
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVES: Patients with rheumatoid arthritis (RA) are at increased risk of lymphoma. There is no biomarker to indicate future lymphoma risk in RA and it is not known whether factors associated with an increased risk of RA also confer an increased risk of lymphoma. We investigated whether anti-cyclic citrullinated peptide (CCP) antibodies, other autoantibodies, and smoking, are associated with lymphoma development in RA.METHOD: subclasses of anti-CCP antibodies and for 15 antinuclear antibody (ANA)-associated specific autoantibodies. Relative risks were estimated as crude and adjusted odds ratios (adjOR) with 95% confidence intervals (CIs) using logistic regression.RESULTS: We found no association between anti-CCP IgG ≥ 25 units/mL (adjOR 1.4, 95% CI 0.7-2.7), anti-CCP IgG ≥ 500 units/mL (adjOR 1.4, 95% CI 0.7-3.0), anti-CCP Ig of other isotypes, other autoantibodies (adjOR any vs none 0.6, 95% CI 0.3-1.2), or cigarette smoking (adjOR ever vs never 1.1, 95% CI 0.5-2.2) and lymphoma risk among patients with RA.CONCLUSION: In this study, neither anti-CCP antibodies (IgG, IgG1–4, IgM, or IgA), nor other common autoantibodies, nor smoking predicted lymphoma risk in RA
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Baecklund, Eva, ...
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Backlin, Carin
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Rönnelid, Johan
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Toes, R
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Huizinga, Twj
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Åhlin, Erik, 198 ...
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show more...
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Askling, J
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Hochberg, F H
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Klareskog, L
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Kay, J
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Smedby, K E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Uppsala University
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Karolinska Institutet