The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage

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Fältnamn	Indikatorer	Metadata
000		04979naa a2200481 4500
001		oai:DiVA.org:uu-382827
003		SwePub
008		190506s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3828272 URI
024	7	a https://doi.org/10.1016/j.devcel.2019.03.0172 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Baek, Sungminu Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
245	1 0	a The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage
264	1	b CELL PRESS,c 2019
338		a print2 rdacarrier
520		a The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The first lymphatic vessels arise from pre-existing veins after venous endothelial cells become specified as lymphatic progenitors. Prox1 specifies lymphatic fate and labels these progenitors; however, the mechanisms restricting Prox1 expression and limiting the progenitor pool remain unknown. We identified a zebrafish mutant that displayed premature, expanded, and prolonged lymphatic specification. The gene responsible encodes the regulator of alternative splicing, Nova2. In zebrafish and human endothelial cells, Nova2 selectively regulates pre-mRNA splicing for components of signaling pathways and phosphoproteins. Nova2-deficient endothelial cells display increased Mapk/Erk signaling, and Prox1 expression is dynamically controlled by Erk signaling. We identify a mechanism whereby Nova2-regulated splicing constrains Erk signaling, thus limiting lymphatic progenitor cell specification. This identifies the capacity of a factor that tunes mRNA splicing to control assignment of cell fate during vascular differentiation.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
700	1	a Oh, Tae Gyuu Univ Queensland, Inst Mol Biosci, Div Cell Biol & Mol Med, Brisbane, Qld 4073, Australia4 aut
700	1	a Secker, Genevieveu Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia;SA Pathol, Adelaide, SA 5000, Australia4 aut
700	1	a Sutton, Drew L.u Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia;SA Pathol, Adelaide, SA 5000, Australia4 aut
700	1	a Okuda, Kazuhide S.u Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
700	1	a Paterson, Scottu Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
700	1	a Bower, Neil I.u Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
700	1	a Toubia, Johnu Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia;SA Pathol, Adelaide, SA 5000, Australia;Univ South Australia, Ctr Canc Biol, Fdn Canc Genom Facil, Australian Canc Res, Frome Rd, Adelaide, SA 5000, Australia4 aut
700	1	a Koltowska, Katarzynau Uppsala universitet,Vaskulärbiologi,Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut0 (Swepub:uu)katko745
700	1	a Capon, Samuel J.u Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
700	1	a Baillie, Gregory J.u Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
700	1	a Simons, Casu Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia;Murdoch Childrens Res Inst, Parkville, Vic, Australia4 aut
700	1	a Muscat, George E. O.u Univ Queensland, Inst Mol Biosci, Div Cell Biol & Mol Med, Brisbane, Qld 4073, Australia4 aut
700	1	a Lagendijk, Anne K.u Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
700	1	a Smith, Kelly A.u Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
700	1	a Harvey, Natasha L.u Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia;SA Pathol, Adelaide, SA 5000, Australia4 aut
700	1	a Hogan, Benjamin M.u Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australia4 aut
710	2	a Univ Queensland, Inst Mol Biosci, Div Genom Dev & Dis, Brisbane, Qld 4073, Australiab Univ Queensland, Inst Mol Biosci, Div Cell Biol & Mol Med, Brisbane, Qld 4073, Australia4 org
773	0	t Developmental Celld : CELL PRESSg 49:2, s. 279-292q 49:2<279-292x 1534-5807x 1878-1551
856	4	u https://doi.org/10.1016/j.devcel.2019.03.017
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382827
856	4 8	u https://doi.org/10.1016/j.devcel.2019.03.017

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Av författaren/redakt...: Baek, Sungmin; Oh, Tae Gyu; Secker, Geneviev ...; Sutton, Drew L.; Okuda, Kazuhide ...; Paterson, Scott; visa fler...; Bower, Neil I.; Toubia, John; Koltowska, Katar ...; Capon, Samuel J.; Baillie, Gregory ...; Simons, Cas; Muscat, George E ...; Lagendijk, Anne ...; Smith, Kelly A.; Harvey, Natasha ...; Hogan, Benjamin ...; visa färre...

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