L773:1879 0089
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02791naa a2200325 4500 | |
| 001 | oai:DiVA.org:su-31991 | |
| 003 | SwePub | |
| 008 | 091201s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:118073635 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-319912 URI |
| 024 | 7 | a https://doi.org/10.1016/j.dci.2008.08.0092 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1180736352 URI |
| 040 | a (SwePub)sud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Arrighi, Romanico B G4 aut |
| 245 | 1 0 | a The immunogenic properties of protozoan glycosylphosphatidylinositols in the mosquito Anopheles gambiae. |
| 264 | 1 | b Elsevier BV,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a In contrast to humans, mosquitoes do not have an adaptive immune response to deal with pathogens, and therefore must rely on their innate immune system to deal with invaders. This facilitates the recognition of different microbes on the basis of surface components or antigens. Such antigens have been identified in various types of microbe such as bacteria and fungi, yet none has been identified in the genus protozoa, which includes pathogens such as the malaria parasite, Plasmodium falciparum and Toxoplasma gondii. This study allowed us to test the antigenic properties of protozoan glycosylphosphatidylinositol (GPI) on the mosquito immune system. We found that both P. falciparum GPI and T. gondii GPI induce the strong expression of several antimicrobial peptides following ingestion, and that as a result of the immune response against the GPIs, the number of eggs produced by the mosquito is reduced dramatically. Such effects have been associated with malaria infected mosquitoes, but never associated with a Plasmodium specific antigen. This study demonstrates that protozoan GPIs can be considered as protozoan specific immune elicitors in mosquitoes, and that P. falciparum GPI plays a critical role in the malaria parasite manipulation of the mosquito vector to facilitate its transmission. | |
| 700 | 1 | a Debierre-Grockiego, Françoise4 aut |
| 700 | 1 | a Schwarz, Ralph T4 aut |
| 700 | 1 | a Faye, Ingridu Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi4 aut0 (Swepub:su)faye |
| 710 | 2 | a Stockholms universitetb Institutionen för genetik, mikrobiologi och toxikologi4 org |
| 773 | 0 | t Developmental and Comparative Immunologyd : Elsevier BVg 33:2, s. 216-23q 33:2<216-23x 0145-305Xx 1879-0089 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-31991 |
| 856 | 4 8 | u https://doi.org/10.1016/j.dci.2008.08.009 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118073635 |
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