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Sökning: L773:2352 8729 > (2018) > In vivo coupling of...

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FältnamnIndikatorerMetadata
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001oai:DiVA.org:uu-440805
003SwePub
008210420s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:230426064
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4408052 URI
0247 a https://doi.org/10.1016/j.dadm.2018.08.0052 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2304260642 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Mak, Elijahu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut
2451 0a In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease
264 c 2018-09-17
264 1b Wiley,c 2018
338 a electronic2 rdacarrier
520 a Introduction: The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain unclear.Methods: We estimated cortical thickness, tau ([18F]-AV-1451), and amyloid β (Aβ) status ([11C]-PiB) in 47 subjects who were stratified into Aβ- (14 healthy controls and six mild cognitive impairment-Aβ-) and Aβ+ (14 mild cognitive impairment-Aβ+ and 13 AD) groups.Results: Compared with the Aβ- group, tau was increased in widespread regions whereas cortical thinning was restricted to the temporal cortices. Increased tau binding was associated with cortical thinning in each Aβ group. Locally, regional tau was associated with temporoparietal atrophy.Discussion: These findings position tau as a promising therapeutic target. Further studies are needed to elucidate the casual relationships between tau pathology and trajectories of atrophy in AD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer's disease
653 a Amyloid
653 a Atrophy
653 a Cortical thickness
653 a MRI
653 a Positron emission tomography
653 a Tau
7001 a Bethlehem, Richard A Iu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut
7001 a Romero-Garcia, Rafaelu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut
7001 a Cervenka, Simonu Karolinska Institutet4 aut0 (Swepub:uu)simce160
7001 a Rittman, Timothyu Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK4 aut
7001 a Gabel, Silvyu Department of Psychiatry, University of Cambridge, Cambridge, UK; Laboratory for Cognitive Neurology, University of Leuven, Leuven, Belgium4 aut
7001 a Surendranathan, Ajenthanu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut
7001 a Bevan-Jones, Richard Wu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut
7001 a Passamonti, Lucau Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK4 aut
7001 a Vázquez Rodríguez, Patriciau Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK4 aut
7001 a Su, Liu Department of Psychiatry, University of Cambridge, Cambridge, UK; China‐UK Centre for Cognition and Ageing Research, Southwest University, Chongqing, China4 aut
7001 a Arnold, Robertu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut
7001 a Williams, Guy Bu Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut
7001 a Hong, Young Tu Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut
7001 a Fryer, Tim Du Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut
7001 a Aigbirhio, Franklin Iu Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK4 aut
7001 a Rowe, James Bu Medical Research Council, and Brain Sciences Unit, Cambridge, UK; Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK4 aut
7001 a O'Brien, John Tu Department of Psychiatry, University of Cambridge, Cambridge, UK4 aut
7102 a Karolinska Institutetb Department of Psychiatry, University of Cambridge, Cambridge, UK4 org
7730 t Alzheimer's & dementia (Amsterdam, Netherlands)d : Wileyg 10, s. 678-687q 10<678-687x 2352-8729
8564 u https://doi.org/10.1016/j.dadm.2018.08.005y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1546019/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.dadm.2018.08.005
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440805
8564 8u https://doi.org/10.1016/j.dadm.2018.08.005
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:230426064

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