WFRF:(Aboud S)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03218naa a2200529 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:145275631 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1452756312 URI |
| 024 | 7 | a https://doi.org/10.3390/microorganisms81117222 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Msafiri, Fu Karolinska Institutet4 aut |
| 245 | 1 0 | a Frequent Anti-V1V2 Responses Induced by HIV-DNA Followed by HIV-MVA with or without CN54rgp140/GLA-AF in Healthy African Volunteers |
| 264 | c 2020-11-04 | |
| 264 | 1 | b MDPI AG,c 2020 |
| 520 | a Antibody responses that correlated with reduced risk of HIV acquisition in the RV144 efficacy trial were assessed in healthy African volunteers who had been primed three times with HIV-DNA (subtype A, B, C) and then randomized into two groups; group 1 was boosted twice with HIV-MVA (CRF01_AE) and group 2 with the same HIV-MVA coadministered with subtype C envelope (Env) protein (CN54rgp140/GLA-AF). The fine specificity of plasma Env-specific antibody responses was mapped after the final vaccination using linear peptide microarray technology. Binding IgG antibodies to the V1V2 loop in CRF01_AE and subtype C Env and Env-specific IgA antibodies were determined using enzyme-linked immunosorbent assay. Functional antibody-dependent cellular cytotoxicity (ADCC)-mediating antibody responses were measured using luciferase assay. Mapping of linear epitopes within HIV-1 Env demonstrated strong targeting of the V1V2, V3, and the immunodominant region in gp41 in both groups, with additional recognition of two epitopes located in the C2 and C4 regions in group 2. A high frequency of V1V2-specific binding IgG antibody responses was detected to CRF01_AE (77%) and subtype C antigens (65%). In conclusion, coadministration of CN54rgp140/GLA-AF with HIV-MVA did not increase the frequency, breadth, or magnitude of anti-V1V2 responses or ADCC-mediating antibodies induced by boosting with HIV-MVA alone. | |
| 700 | 1 | a Joachim, A4 aut |
| 700 | 1 | a Held, K4 aut |
| 700 | 1 | a Nadai, Y4 aut |
| 700 | 1 | a Chissumba, RM4 aut |
| 700 | 1 | a Geldmacher, C4 aut |
| 700 | 1 | a Aboud, S4 aut |
| 700 | 1 | a Stohr, W4 aut |
| 700 | 1 | a Viegas, E4 aut |
| 700 | 1 | a Kroidl, A4 aut |
| 700 | 1 | a Bakari, M4 aut |
| 700 | 1 | a Munseri, PJ4 aut |
| 700 | 1 | a Wahren, Bu Karolinska Institutet4 aut |
| 700 | 1 | a Sandstrom, E4 aut |
| 700 | 1 | a Robb, ML4 aut |
| 700 | 1 | a McCormack, S4 aut |
| 700 | 1 | a Joseph, S4 aut |
| 700 | 1 | a Jani, I4 aut |
| 700 | 1 | a Ferrari, G4 aut |
| 700 | 1 | a Rao, M4 aut |
| 700 | 1 | a Biberfeld, Gu Karolinska Institutet4 aut |
| 700 | 1 | a Lyamuya, E4 aut |
| 700 | 1 | a Nilsson, Cu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Microorganismsd : MDPI AGg 8:11q 8:11x 2076-2607 |
| 856 | 4 | u https://www.mdpi.com/2076-2607/8/11/1722/pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145275631 |
| 856 | 4 8 | u https://doi.org/10.3390/microorganisms8111722 |
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- Msafiri, F
- Joachim, A
- Held, K
- Nadai, Y
- Chissumba, RM
- Geldmacher, C
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- Aboud, S
- Stohr, W
- Viegas, E
- Kroidl, A
- Bakari, M
- Munseri, PJ
- Wahren, B
- Sandstrom, E
- Robb, ML
- McCormack, S
- Joseph, S
- Jani, I
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- Rao, M
- Biberfeld, G
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