Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Affret Aurelie) > Circulating copper ...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		06956naa a2201057 4500
001		oai:lup.lub.lu.se:2a6cada5-4721-413b-a436-b6e078744128
003		SwePub
008		181002s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-133525
009		oai:prod.swepub.kib.ki.se:135302690
024	7	a https://lup.lub.lu.se/record/2a6cada5-4721-413b-a436-b6e0787441282 URI
024	7	a https://doi.org/10.1038/bjc.2017.12 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1335252 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1353026902 URI
040		a (SwePub)lud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Stepien, Magdalenau International Agency for Research on Cancer, World Health Organization4 aut
245	1 0	a Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
264		c 2017-02-02
264	1	b Springer Science and Business Media LLC,c 2017
300		a 9 s.
520		a BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.RESULTS: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed.CONCLUSIONS: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653		a Aged
653		a Biliary Tract Neoplasms/epidemiology
653		a Carcinoma, Hepatocellular/epidemiology
653		a Case-Control Studies
653		a Copper/blood
653		a Europe/epidemiology
653		a Female
653		a Humans
653		a Liver Neoplasms/epidemiology
653		a Male
653		a Middle Aged
653		a Prospective Studies
653		a Zinc/blood
653		a copper
700	1	a Hughes, David Ju Royal College of Surgeons in Ireland4 aut
700	1	a Hybsier, Sandrau Charité - University Medicine Berlin4 aut
700	1	a Bamia, Christinau Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens4 aut
700	1	a Tjønneland, Anneu Danish Cancer Society4 aut
700	1	a Overvad, Kimu Aarhus University4 aut
700	1	a Affret, Aurélieu Institut Gustave Roussy,University of Paris-Saclay4 aut
700	1	a His, Mathildeu University of Paris-Saclay,Institut Gustave Roussy4 aut
700	1	a Boutron-Ruault, Marie-Christineu Institut Gustave Roussy,University of Paris-Saclay4 aut
700	1	a Katzke, Verenau German Cancer Research Centre4 aut
700	1	a Kühn, Tilmanu German Cancer Research Centre4 aut
700	1	a Aleksandrova, Krasimira4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Lagiou, Pagona4 aut
700	1	a Orfanos, Phlippos4 aut
700	1	a Palli, Domenico4 aut
700	1	a Sieri, Sabina4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Ricceri, Fulvio4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Bueno-de-Mesquita, H B As4 aut
700	1	a Peeters, Petra H4 aut
700	1	a Weiderpass, Elisabeteu Karolinska Institutet4 aut
700	1	a Lasheras, Cristina4 aut
700	1	a Bonet Bonet, Catalina4 aut
700	1	a Molina-Portillo, Elena4 aut
700	1	a Dorronsoro, Miren4 aut
700	1	a Huerta, José María4 aut
700	1	a Barricarte, Aurelio4 aut
700	1	a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-boh
700	1	a Sjöberg, Klasu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-ksj
700	1	a Werner, Mårtenu Umeå universitet,Umeå University,Medicin4 aut0 (Swepub:umu)manwer04
700	1	a Shungin, Dmitryu Umeå universitet,Umeå University,Institutionen för odontologi,Medicin4 aut0 (Swepub:lu)med-dsn
700	1	a Wareham, Nick4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Travis, Ruth C4 aut
700	1	a Freisling, Heinz4 aut
700	1	a Cross, Amanda Ju International Agency for Research on Cancer, World Health Organization4 aut
700	1	a Schomburg, Lutz4 aut
700	1	a Jenab, Mazdau International Agency for Research on Cancer, World Health Organization4 aut
710	2	a International Agency for Research on Cancer, World Health Organizationb Royal College of Surgeons in Ireland4 org
773	0	t British Journal of Cancerd : Springer Science and Business Media LLCg 116:5, s. 688-696q 116:5<688-696x 1532-1827x 0007-0920
856	4	u http://dx.doi.org/10.1038/bjc.2017.1x freey FULLTEXT
856	4	u https://www.nature.com/articles/bjc20171.pdf
856	4	u https://umu.diva-portal.org/smash/get/diva2:1095612/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://lup.lub.lu.se/record/2a6cada5-4721-413b-a436-b6e078744128
856	4 8	u https://doi.org/10.1038/bjc.2017.1
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133525
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:135302690

Hitta via bibliotek

British Journal of Cancer (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Artiklar i publikationen: British Journal ...

Av lärosätet: Lunds universitet; Umeå universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se