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Search: WFRF:(Aguilera Maria) > (2015-2019) > Increased humoral i...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006484naa a2200481 4500
001oai:DiVA.org:liu-121427
003SwePub
008150918s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1214272 URI
0247 a https://doi.org/10.1136/gutjnl-2013-3062362 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Vicario, Mariau Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut
2451 0a Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations
264 c 2014-09-10
264 1b BMJ PUBLISHING GROUP,c 2015
338 a print2 rdacarrier
500 a Funding Agencies|Fondo de Investigacion Sanitaria; CIBERehd, Instituto de Salud Carlos III, Subdireccion General de Investigacion Sanitaria, Ministerio de Economia y Competitividad [CP10/00502, PI13/00935, CM08/00229, CM10/00155, FI12/00254, PI12/00314, EII2011-0035, PI11/00716]; Ministerio de Educacion, Direccion General de Investigacion [SAF 2009-07416]; Agencia de Gestio dAjuts Universitaris i de Recerca, de la Generalitat de Catalunya [2009 SGR 219, 2011 BP/A00099]; Rome Foundation; Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas [CB06/04/0021]
520 a Background and aims Altered intestinal barrier is associated with immune activation and clinical symptoms in diarrhoea-predominant IBS (IBS-D). Increased mucosal antigen load may induce specific responses; however, local antibody production and its contribution to IBS aetiopathogenesis remain undefined. This study evaluated the role of humoral activity in IBS-D. Methods A single mucosal jejunal biopsy, luminal content and blood were obtained from healthy volunteers (H; n = 30) and IBS-D (n = 49; Rome III criteria) participants. Intraepithelial lymphocytes, mast cells, B lymphocytes and plasma cells were studied by imaging techniques. Differential gene expression and pathway analysis were assessed by microarray and PCR techniques. Blood and luminal immunoglobulins (Igs) were quantified. Gastrointestinal symptoms, respiratory atopy and stress and depression were also recorded. Results Patients with IBS-D showed a higher number and activation of mucosal B lymphocytes and plasma cells (p less than 0.05). Mast cell density was increased in patients with IBS-D (non-atopic) and in close proximity to plasma cells (p less than 0.05). Microarray profiling identified differential humoral activity in IBS-D, involving proliferation and activation of B lymphocytes and Igs production (p less than 0.001). Mucosal humoral activity was higher in IBS-D, with upregulation of germline transcripts and Ig genes (1.3-fold-1.7-fold increase; p less than 0.05), and increased IgG(+) cells and luminal IgG compared with H (p less than 0.05), with no differences in blood. Biological markers of humoral activity correlated positively with bowel movements, stool form and depression. Conclusions Enhanced small bowel humoral immunity is a distinctive feature of IBS-D. Mucosal Ig production contributes to local inflammation and clinical manifestations in IBS-D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
7001 a Gonzalez-Castro, Ana M.u Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Martinez, Cristinau Heidelberg University, Germany4 aut
7001 a Lobo, Beatrizu Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Pigrau, Marcu Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Guilarte, Maru University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a de Torres, Inesu University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Mosquera, Jose L.u University of Barcelona, Spain4 aut
7001 a Fortea, Marinau Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Sevillano-Aguilera, Cesaru Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Salvo-Romero, Eloisau Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Alonso, Carmenu Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut
7001 a Rodino-Janeiro, Bruno K.u Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 aut
7001 a Söderholm, Johan D.u Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US4 aut0 (Swepub:liu)sodda63
7001 a Azpiroz, Fernandou Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut
7001 a Santos, Javieru Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spain4 aut
7102 a Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain; Centre Invest Biomed Red Enfermedades Hepat and Digest, Spainb Vall dHebron Institute Recerca, Spain; University of Autonoma Barcelona, Spain; University of Autonoma Barcelona, Spain4 org
7730 t Gutd : BMJ PUBLISHING GROUPg 64:9, s. 1379-1388q 64:9<1379-1388x 0017-5749x 1468-3288
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121427
8564 8u https://doi.org/10.1136/gutjnl-2013-306236

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