Positron emission tomography in the diagnosis and staging of urinary bladder cancer

Andersson, J (author): Institutionen för läkemedelskemi; Plattformen för preklinisk PET, Uppsala university, Uppsala

Långström, Bengt (author): Institutionen för läkemedelskemi; Plattformen för preklinisk PET, Uppsala university, Uppsala

(creator_code:org_t)

Abstract Subject headings

PURPOSE: Evaluation of positron emission tomography (PET) using (18)fl 18F-2-fluoro-2-deoxy-D-glucose (18FDG) and L-methyl-11C-methionine in the diagnosis and staging of urinary bladder carcinoma. MATERIAL AND METHODS: Twenty-three patients with biopsy-proven urinary bladder carcinoma were examined with PET after intravenous injection of 11C-methionine; 2 were also examined with 18FDG. The results from the PET investigations were compared with CT or MR findings and TNM classification before and after treatment. RESULTS: The urinary excretion of 18FDG prevented distinction of the primary tumour from the surrounding tracer. With 11C-methionine it was possible to detect 18/23 primary tumours. A trend was seen, suggesting that the higher the uptake values of 11C-methionine in the tumour, the greater the tumour stage. CONCLUSION: It is possible to visualize urinary bladder tumours larger than 1 cm in diameter with PET using (11)C-methionine, but the value of the method in the staging of the lesions is not superior to conventional methods.

By the author/editor: Ahlström, Håkan; Malmström, Per-U ...; Letocha, H; Andersson, J; Långström, Bengt; Nilsson, S

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