Growth Promoting Treatment Normalizes Speech Frequency in Turner Syndrome

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Andersson Ann Christine) > (2005-2009) > Growth Promoting Tr...

Growth Promoting Treatment Normalizes Speech Frequency in Turner Syndrome

Andersson-Wallgren, Gunnel (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences

Ohlsson, Ann-Christine (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology

Albertsson-Wikland, Kerstin, 1947 (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences

Barrenäs, Marie-Louise, 1952 (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences

show less...

(creator_code:org_t)

2008
2008
English.
In: Laryngoscope. - 0023-852X. ; 118:6, s. 1125-1130

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

OBJECTIVE:: To assess objective and subjective voice parameters among Turner syndrome (TS) women in relation to genotype, hearing, growth, and previous treatment with growth hormone (GH) and androgen given that lowering of speaking fundamental frequency (SFF) during treatment is regarded as a negative side effect. STUDY DESIGN:: Cross-sectional, controlled for karyotype and age. METHODS:: Voice function was studied objectively (SFF) and subjectively (questionnaire) in 117 women with TS. RESULTS:: SFF did not differ between treated and nontreated participants or between patients with a spontaneous versus induced puberty. SFF was dependent on karyotype but not age. Subjective voice change was reported four times more often among treated compared with nontreated TS women (odds ratio [OR] = 4.4; 95% confidence interval [CI]: 0.9-20.10), whereas voice and articulation problems were reported three times more often among untreated compared with treated cases (OR = 2.9; 95% CI: 1.0-8.3). Voice symptoms were over-represented among patients having micrognathia (OR = 6.0; 95% CI: 1.6-22.3), hearing loss (OR = 8.6; 95% CI: 1.7-43.1), and monosomy (OR = 6.2; 95% CI: 0.8-36.2) but not among those with an arched palate. CONCLUSIONS:: When given to TS girls, GH (33-66 mug/kg/d) and androgen (0.05 mg/kg/d) normalized SFF and reduced voice and articulation problems in adulthood. The TS phenotype includes important voice and speech problems, which in turn are associated with hearing problems, although genotypic, monosomic, and isochromosome patients have more voice problems and also more high-pitched voices than mosaic patients. Most TS women, despite their karyotype or age, exhibit a higher frequency of pitched voice than non-TS women.

Keyword

Turner genotype
voice
phenotype
hormone replacement therapy
growth hormone

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Laryngoscope (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Andersson-Wallgr ...; Ohlsson, Ann-Chr ...; Albertsson-Wikla ...; Barrenäs, Marie- ...

Articles in the publication: Laryngoscope

By the university: University of Gothenburg

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se