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Use of combined hor...
Use of combined hormonal contraceptives among women with systemic lupus erythematosus with and without medical contraindications to oestrogen
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- Mendel, Arielle (author)
- McGill University Health Center
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- Bernatsky, Sasha (author)
- McGill University Health Center
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- Pineau, Christian A. (author)
- McGill University Health Center
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- St-Pierre, Yvan (author)
- McGill University Health Center
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- Hanly, John G. (author)
- Dalhousie University
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- Urowitz, Murray B. (author)
- Toronto Western Hospital,University of Toronto
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- Clarke, Ann E. (author)
- University of Calgary
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- Romero-Diaz, Juanita (author)
- Instituto Nacional de Ciencias Médicas y Nutrición
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- Gordon, Caroline (author)
- University of Birmingham,City Hospital, Birmingham
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- Bae, Sang Cheol (author)
- Hanyang University
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- Wallace, Daniel J. (author)
- Cedars-Sinai Medical Center,University of California, Los Angeles
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- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation
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- Buyon, Jill (author)
- New York University
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- Isenberg, David A. (author)
- University College London
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- Rahman, Anisur (author)
- University College London
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- Ginzler, Ellen M. (author)
- SUNY Downstate Health Sciences University
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Dooley, Mary Anne (author)
- University of North Carolina
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- Fortin, Paul (author)
- Centre hospitalier universitaire de Québec
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- Gladman, Dafna D. (author)
- Toronto Western Hospital,University of Toronto
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- Steinsson, Kristján (author)
- National University Hospital of Iceland
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
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- Khamashta, Munther A. (author)
- University College London
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
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- MacKay, Meggan (author)
- Feinstein Institute for Medical Research
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- Alarcón, Graciela (author)
- University of Alabama
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- Manzi, Susan (author)
- Allegheny Health Network
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Zoma, Asad A. (author)
- Hairmyres Hospital
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- Van Vollenhoven, Ronald F. (author)
- Karolinska Institutet,Karolinska Institute
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- Ramos-Casals, Manuel (author)
- Hospital Clínic of Barcelona
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- Ruiz-Irastorza, Giuillermo (author)
- University of the Basque Country
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- Lim, Sam (author)
- Emory University
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- Kalunian, Kenneth C. (author)
- University of California, San Diego
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- Inanc, Murat (author)
- Istanbul University
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Peschken, Christine A. (author)
- University of Manitoba
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- Jacobsen, Søren (author)
- Copenhagen University Hospital,University of Copenhagen
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- Askanase, Anca (author)
- Columbia University
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- Sanchez-Guerrero, Jorge (author)
- University of Toronto,Mount Sinai Hospital of University of Toronto
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- Bruce, Ian N. (author)
- University of Manchester,Manchester University NHS Foundation Trust
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- Costedoat-Chalumeau, Nathalie (author)
- Cochin Hospital
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- Vinet, Evelyne (author)
- McGill University Health Center
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(creator_code:org_t)
- 2019-02-08
- 2019
- English 9 s.
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In: Rheumatology (United Kingdom). - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 58:7, s. 1259-1267
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- Objectives. To assess the prevalence of combined hormonal contraceptives (CHCs) in reproductive-age women with SLE with and without possible contraindications and to determine factors associated with their use in the presence of possible contraindications. Methods. This observational cohort study included premenopausal women ages 18-45 years enrolled in the SLICC Registry ≤15 months after SLE onset, with annual assessments spanning 2000-2017. World Health Organization Category 3 or 4 contraindications to CHCs (e.g. hypertension, aPL) were assessed at each study visit. High disease activity (SLEDAI score >12 or use of >0.5 mg/kg/day of prednisone) was considered a relative contraindication. Results. A total of 927 SLE women contributed 6315 visits, of which 3811 (60%) occurred in the presence of one or more possible contraindication to CHCs. Women used CHCs during 512 (8%) visits, of which 281 (55%) took place in the setting of one or more possible contraindication. The most frequently observed contraindications were aPL (52%), hypertension (34%) and migraine with aura (22%). Women with one or more contraindication were slightly less likely to be taking CHCs [7% of visits (95% CI 7, 8)] than women with no contraindications [9% (95% CI 8, 10)]. Conclusion. CHC use was low compared with general population estimates (>35%) and more than half of CHC users had at least one possible contraindication. Many yet unmeasured factors, including patient preferences, may have contributed to these observations. Further work should also aim to clarify outcomes associated with this exposure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Anti-phospholipid syndrome
- Contraception
- Epidemiology
- Systemic lupus erythematosus
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Mendel, Arielle
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Bernatsky, Sasha
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Pineau, Christia ...
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St-Pierre, Yvan
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Hanly, John G.
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Urowitz, Murray ...
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show more...
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Clarke, Ann E.
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Romero-Diaz, Jua ...
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Gordon, Caroline
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Bae, Sang Cheol
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Wallace, Daniel ...
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Merrill, Joan T.
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Buyon, Jill
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Isenberg, David ...
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Rahman, Anisur
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Ginzler, Ellen M ...
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Petri, Michelle
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Dooley, Mary Ann ...
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Fortin, Paul
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Gladman, Dafna D ...
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Khamashta, Munth ...
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Aranow, Cynthia
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MacKay, Meggan
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Alarcón, Graciel ...
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Manzi, Susan
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Nived, Ola
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Jönsen, Andreas
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Zoma, Asad A.
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Van Vollenhoven, ...
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Ramos-Casals, Ma ...
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Ruiz-Irastorza, ...
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Lim, Sam
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Kalunian, Kennet ...
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Inanc, Murat
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Kamen, Diane L.
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Peschken, Christ ...
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Jacobsen, Søren
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Askanase, Anca
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Sanchez-Guerrero ...
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Bruce, Ian N.
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Costedoat-Chalum ...
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Vinet, Evelyne
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Rheumatology (Un ...
- By the university
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Lund University
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Karolinska Institutet