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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005522naa a2200541 4500
001oai:DiVA.org:uu-425492
003SwePub
008201118s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4254922 URI
0247 a https://doi.org/10.1016/j.ejps.2020.1055172 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Augustijns, Patricku Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium.4 aut
2451 0a Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique :b History, methodology and applications
264 1b ELSEVIER,c 2020
338 a electronic2 rdacarrier
520 a Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain more insight into the fluids present in the human GI tract and to explore the dynamic interplay of drug release, dissolution, precipitation and absorption after drug product administration to healthy subjects. In the last twenty years, collaborative initiatives have led to a plethora of clinical aspiration studies that aimed to unravel the luminal drug behavior of an orally administered drug product. The obtained drug concentration-time profiles from different segments in the GI tract were a valuable source of information to optimize and/or validate predictive in vitro and in silico tools, frequently applied in the non-clinical stage of drug product development. Sampling techniques are presently not only being considered as a stand-alone technique but are also used in combination with other in vivo techniques (e.g., gastric motility recording, magnetic resonance imaging (MRI)). By doing so, various physiological variables can be mapped simultaneously and evaluated for their impact on luminal drug and formulation behavior. This comprehensive review aims to describe the history, challenges and opportunities of the aspiration technique with a specific focus on how this technique can unravel the luminal behavior of drug products inside the human GI tract by providing a summary of studies performed over the last 20 years. A section `Best practices' on how to perform the studies and how to treat the aspirated samples is described. In the conclusion, we focus on future perspectives concerning this technique.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653 a Gastrointestinal drug concentrations
653 a Intestinal absorption
653 a Intraluminal drug and formulation behavior
653 a Sampling technique
653 a Aspiration studies
7001 a Vertzoni, Mariau Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece.4 aut
7001 a Reppas, Christosu Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece.4 aut
7001 a Langguth, Peteru Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, D-55131 Mainz, Germany.4 aut
7001 a Lennernäs, Hansu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)hanslenn
7001 a Abrahamsson, Bertilu AstraZeneca Gothenburg, Operat, Oral Prod Dev Pharmaceut Technol & Dev, S-43183 Molndal, Sweden.4 aut
7001 a Hasler, William L.u Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.4 aut
7001 a Baker, Jason R.u Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.4 aut
7001 a Vanuytsel, Timu Katholieke Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium.4 aut
7001 a Tack, Janu Katholieke Univ Leuven, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium.4 aut
7001 a Corsetti, Maurau Nottingham Univ Hosp NHS Trust, NIHR Nottingham Biomed Res Ctr BRC, Nottingham, England.;Univ Nottingham, Nottingham, England.;Univ Nottingham, Nottingham Digest Dis Ctr, Sch Med, Nottingham, England.4 aut
7001 a Bermejo, Marivalu Miguel Hernandez Univ, Dept Engn Pharm Sect, Alicante 03550, Spain.4 aut
7001 a Paixao, Paulou Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.4 aut
7001 a Amidon, Gordon L.u Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA.4 aut
7001 a Hens, Bartu Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium.4 aut
7102 a Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Drug Delivery & Disposit, Herestr 49,Box 921, B-3000 Leuven, Belgium.b Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens, Greece.4 org
7730 t European Journal of Pharmaceutical Sciencesd : ELSEVIERg 155q 155x 0928-0987x 1879-0720
8564 u https://doi.org/10.1016/j.ejps.2020.105517y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1501775/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.ejps.2020.105517
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-425492
8564 8u https://doi.org/10.1016/j.ejps.2020.105517

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