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FältnamnIndikatorerMetadata
00021501naa a2201525 4500
001oai:DiVA.org:umu-196479
003SwePub
008220614s2022 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:8282a024-e8a8-4a63-917b-48f78d2a61e3
009oai:gup.ub.gu.se/320971
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1964792 URI
024a https://doi.org/10.1007/s00198-022-06435-62 DOI
024a https://lup.lub.lu.se/record/8282a024-e8a8-4a63-917b-48f78d2a61e32 URI
024a https://gup.ub.gu.se/publication/3209712 URI
040 a (SwePub)umud (SwePub)lud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
100a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,University of Gothenburg,Australian Catholic University,Sahlgrenska Academy,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xvanli
2451 0a Update of the fracture risk prediction tool FRAX :b a systematic review of potential cohorts and analysis plan
264 c 2022-05-31
264 1b Springer,c 2022
338 a print2 rdacarrier
520 a Summary: We describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.Introduction: The availability of the fracture risk assessment tool FRAX® has substantially enhanced the targeting of treatment to those at high risk of fracture with FRAX now incorporated into more than 100 clinical osteoporosis guidelines worldwide. The aim of this study is to determine whether the current algorithms can be further optimised with respect to current and novel risk factors.Methods: A computerised literature search was performed in PubMed from inception until May 17, 2019, to identify eligible cohorts for updating the FRAX coefficients. Additionally, we searched the abstracts of conference proceedings of the American Society for Bone and Mineral Research, European Calcified Tissue Society and World Congress of Osteoporosis. Prospective cohort studies with data on baseline clinical risk factors and incident fractures were eligible.Results: Of the 836 records retrieved, 53 were selected for full-text assessment after screening on title and abstract. Twelve cohorts were deemed eligible and of these, 4 novel cohorts were identified. These cohorts, together with 60 previously identified cohorts, will provide the resource for constructing an updated version of FRAX comprising 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures. For each known and candidate risk factor, multivariate hazard functions for hip fracture, major osteoporotic fracture and death will be tested using extended Poisson regression. Sex- and/or ethnicity-specific differences in the weights of the risk factors will be investigated. After meta-analyses of the cohort-specific beta coefficients for each risk factor, models comprising 10-year probability of hip and major osteoporotic fracture, with or without femoral neck bone mineral density, will be computed.Conclusions: These assembled cohorts and described models will provide the framework for an updated FRAX tool enabling enhanced assessment of fracture risk (PROSPERO (CRD42021227266)).
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Epidemiology
653 a Fracture probability
653 a FRAX
653 a Hip fracture
653 a Major osteoporotic fracture
653 a Risk assessment
653 a Epidemiology; Fracture probability; FRAX; Hip fracture; Major osteoporotic fracture; Risk assessment
700a Johansson, H.u Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, United Kingdom4 aut
700a McCloskey, E.V.u Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, United Kingdom; MRC Versus Arthritis Centre for Integrated Research in Musculoskeletal Ageing, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, United Kingdom4 aut
700a Liu, E.u Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia4 aut
700a Åkesson, K.E.u Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)orto-kak
700a Anderson, F.A.u GLOW Coordinating Center, Center for Outcomes Research, University of Massachusetts Medical School, MA, Worcester, United States4 aut
700a Azagra, R.u Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain; Health Center Badia del Valles, Catalan Institute of Health, Barcelona, Spain; GROIMAP (Research Group), Unitat de Suport a La Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol, Santa Coloma de Gramenet, Barcelona, Spain4 aut
700a Bager, C.L.u Nordic Bioscience A/S, Herlev, Denmark4 aut
700a Beaudart, C.u WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium4 aut
700a Bischoff-Ferrari, H.A.u Department of Aging Medicine and Aging Research, University Hospital, Zurich, and University of Zurich, Zurich, Switzerland; Centre On Aging and Mobility, University of Zurich and City Hospital, Zurich, Switzerland4 aut
700a Biver, E.u Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland4 aut
700a Bruyère, O.u WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium4 aut
700a Cauley, J.A.u Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Philadelphia, United States4 aut
700a Center, J.R.u Bone Biology, Healthy Ageing Theme, Garvan Institute of Medical Research, NSW, Sydney, Australia; St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, NSW, Sydney, Australia; School of Medicine Sydney, University of Notre Dame Australia, NSW, Sydney, Australia4 aut
700a Chapurlat, R.u INSERM UMR 1033, University of Lyon, Hôpital Edouard Herriot, Lyon, France4 aut
700a Christiansen, C.u Nordic Bioscience A/S, Herlev, Denmark4 aut
700a Cooper, C.u MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom; National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, Oxford, United Kingdom4 aut
700a Crandall, C.J.u Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, CA, Los Angeles, United States4 aut
700a Cummings, S.R.u San Francisco Coordinating Center, California Pacific Medical Center Research Institute, CA, San Francisco, United States4 aut
700a da Silva, J.A.P.u Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Rheumatology Department, University Hospital and University of Coimbra, Coimbra, Portugal4 aut
700a Dawson-Hughes, B.u Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center On Aging, Tufts University, MA, Boston, United States4 aut
700a Diez-Perez, A.u Department of Internal Medicine, Hospital del Mar and CIBERFES, Autonomous University of Barcelona, Barcelona, Spain4 aut
700a Dufour, A.B.u Marcus Institute for Aging Research, Hebrew SeniorLife, MA, Boston, United States; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, MA, Boston, United States4 aut
700a Eisman, J.A.u St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, NSW, Sydney, Australia; School of Medicine Sydney, University of Notre Dame Australia, NSW, Sydney, Australia; Osteoporosis and Bone Biology Division, Garvan Institute of Medical Research, NSW, Sydney, Australia4 aut
700a Elders, P.J.M.u Department of General Practice, Amsterdam UMC, Location VUmc, Amsterdam Public Health Research Institute, Amsterdam, Netherlands4 aut
700a Ferrari, S.u Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland4 aut
700a Fujita, Y.u Department of Public Health, Faculty of Medicine, Kindai University, Osaka, Japan4 aut
700a Fujiwara, S.u Department of Pharmacy, Yasuda Women’s University, Hiroshima, Japan4 aut
700a Glüer, C.-C.u Section Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein Kiel, Kiel University, Kiel, Germany4 aut
700a Goldshtein, I.u Maccabitech Institute of Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel4 aut
700a Goltzman, D.u Department of Medicine, McGill University and McGill University Health Centre, Montreal, Canada4 aut
700a Gudnason, V.u Icelandic Heart Association, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland4 aut
700a Hall, J.u MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom4 aut
700a Hans, D.u Centre of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Lausanne, Switzerland4 aut
700a Hoff, M.u Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway; Department of Rheumatology, St Olavs Hospital, Trondheim, Norway4 aut
700a Hollick, R.J.u Aberdeen Centre for Arthritis and Musculoskeletal Health, Epidemiology Group, University of Aberdeen, Aberdeen, United Kingdom4 aut
700a Huisman, M.u Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands; Department of Sociology, VU University, Amsterdam, Netherlands4 aut
700a Iki, M.u Department of Public Health, Faculty of Medicine, Kindai University, Osaka, Japan4 aut
700a Ish-Shalom, S.u Endocrine Clinic, Elisha Hospital, Haifa, Israel4 aut
700a Jones, G.u Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia4 aut
700a Karlsson, M.K.u Lund University,Lunds universitet,Psykiatri,Forskargrupper vid Lunds universitet,Psychiatry,Lund University Research Groups4 aut0 (Swepub:lu)ymed-mse
700a Khosla, S.u Robert and Arlene Kogod Center On Aging and Division of Endocrinology, Mayo Clinic College of Medicine, Mayo Clinic, MN, Rochester, United States4 aut
700a Kiel, D.P.u Marcus Institute for Aging Research, Hebrew SeniorLife, MA, Boston, United States; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, MA, Boston, United States4 aut
700a Koh, W.-P.u Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore4 aut
700a Koromani, F.u Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands4 aut
700a Kotowicz, M.A.u IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, VIC, Geelong, Australia; Barwon Health, VIC, Geelong, Australia; Department of Medicine - Western Health, The University of Melbourne, St Albans, Victoria, Australia4 aut
700a Kröger, H.u Department of Orthopedics and Traumatology, Kuopio University Hospital, Kuopio, Finland; Kuopio Musculoskeletal Research Unit, University of Eastern Finland, Kuopio, Finland4 aut
700a Kwok, T.u Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Jockey Club Centre for Osteoporosis Care and Control, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong4 aut
700a Lamy, O.u Centre of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland; Service of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland4 aut
700a Langhammer, A.u Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology, Trondheim, Norway4 aut
700a Larijani, B.u Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran4 aut
700a Lippuner, K.u Department of Osteoporosis, Bern University Hospital, University of Bern, Bern, Switzerland4 aut
700a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xmelda
700a Merlijn, T.u Department of General Practice, Amsterdam UMC, Location VUmc, Amsterdam Public Health Research Institute, Amsterdam, Netherlands4 aut
700a Nordström, Annikau Umeå universitet,Avdelningen för hållbar hälsa,School of Sport Sciences, Arctic University of Norway, Tromsø, Norway4 aut0 (Swepub:umu)anno0103
700a Nordström, Peteru Umeå universitet,Geriatrik4 aut0 (Swepub:umu)peno0014
700a O’Neill, T.W.u National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom; Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom4 aut
700a Obermayer-Pietsch, B.u Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria; Center for Biomarker Research in Medicine, Graz, Austria4 aut
700a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl
700a Orwoll, E.S.u Department of Medicine, Oregon Health and Science University, OR, Portland, United States4 aut
700a Pasco, J.A.u Institute for Physical and Mental Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia; Department of Medicine-Western Health, The University of Melbourne, St Albans, Australia; Barwon Health, Geelong, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia4 aut
700a Rivadeneira, F.u Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands4 aut
700a Schei, B.u Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; Department of Gynecology, St Olavs Hospital, Trondheim, Norway4 aut
700a Schott, A.-M.u Université Claude Bernard Lyon 1, U INSERM 1290 RESHAPE, Lyon, France4 aut
700a Shiroma, E.J.u Laboratory of Epidemiology and Population Sciences, National Institute On Aging, MD, Baltimore, United States4 aut
700a Siggeirsdottir, K.u Icelandic Heart Association, Kopavogur, Iceland; Janus Rehabilitation, Reykjavik, Iceland4 aut
700a Simonsick, E.M.u Translational Gerontology Branch, National Institute On Aging Intramural Research Program, MD, Baltimore, United States4 aut
700a Sornay-Rendu, E.u INSERM Research Unit 1033, Lyon, France4 aut
700a Sund, R.u Kuopio Musculoskeletal Research Unit, University of Eastern Finland, Kuopio, Finland4 aut
700a Swart, K.M.A.u Department of General Practice, Amsterdam UMC, Location VUmc, Amsterdam Public Health Research Institute, Amsterdam, Netherlands4 aut
700a Szulc, P.u INSERM UMR 1033, University of Lyon, Hôpital Edouard Herriot, Lyon, France4 aut
700a Tamaki, J.u Department of Hygiene and Public Health, Faculty of Medicine, Educational Foundation of Osaka Medical and Pharmaceutical University, Osaka, Japan4 aut
700a Torgerson, D.J.u York Trials Unit, Department of Health Sciences, University of York, York, United Kingdom4 aut
700a van Schoor, N.M.u Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands4 aut
700a van Staa, T.P.u Centre for Health Informatics, Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester, United Kingdom4 aut
700a Vila, J.u Statistics Support Unit, Hospital del Mar Medical Research Institute, CIBER Epidemiology and Public Health (CIBERESP), Barcelona, Spain4 aut
700a Wareham, N.J.u MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom4 aut
700a Wright, N.C.u Department of Epidemiology, University of Alabama at Birmingham, AL, Birmingham, United States4 aut
700a Yoshimura, N.u Department of Preventive Medicine for Locomotive Organ Disorders, The University of Tokyo Hospital, Tokyo, Japan4 aut
700a Zillikens, M.C.u Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands4 aut
700a Zwart, M.u Health Center Can Gibert del Plà, Catalan Institute of Health, Girona, Spain; Department of Medical Sciences, University of Girona, Girona, Spain; GROIMAP (Research Group), Institut Universitari d’Investigació en Atenció Primària Jordi Gol, Barcelona, Spain4 aut
700a Harvey, N.C.u MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom4 aut
700a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlomat
700a Leslie, W.D.u Department of Medicine, University of Manitoba, MB, Winnipeg, Canada4 aut
700a Kanis, J.A.u Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, United Kingdom; Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, United Kingdom4 aut
710a University of Gothenburgb Australian Catholic University4 org
710a et al.
773t Osteoporosis Internationald : Springerg 33:10, s. 2103-2136q 33:10<2103-2136x 0937-941Xx 1433-2965
856u http://dx.doi.org/10.1007/s00198-022-06435-6y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-196479
8564 8u https://doi.org/10.1007/s00198-022-06435-6
8564 8u https://lup.lub.lu.se/record/8282a024-e8a8-4a63-917b-48f78d2a61e3
8564 8u https://gup.ub.gu.se/publication/320971

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Vandenput, Liesb ...
Johansson, H.
McCloskey, E.V.
Liu, E.
Åkesson, K.E.
Anderson, F.A.
visa fler...
Azagra, R.
Bager, C.L.
Beaudart, C.
Bischoff-Ferrari ...
Biver, E.
Bruyère, O.
Cauley, J.A.
Center, J.R.
Chapurlat, R.
Christiansen, C.
Cooper, C.
Crandall, C.J.
Cummings, S.R.
da Silva, J.A.P.
Dawson-Hughes, B ...
Diez-Perez, A.
Dufour, A.B.
Eisman, J.A.
Elders, P.J.M.
Ferrari, S.
Fujita, Y.
Fujiwara, S.
Glüer, C.-C.
Goldshtein, I.
Goltzman, D.
Gudnason, V.
Hall, J.
Hans, D.
Hoff, M.
Hollick, R.J.
Huisman, M.
Iki, M.
Ish-Shalom, S.
Jones, G.
Karlsson, M.K.
Khosla, S.
Kiel, D.P.
Koh, W.-P.
Koromani, F.
Kotowicz, M.A.
Kröger, H.
Kwok, T.
Lamy, O.
Langhammer, A.
Larijani, B.
Lippuner, K.
Mellström, Dan, ...
Merlijn, T.
Nordström, Annik ...
Nordström, Peter
O’Neill, T.W.
Obermayer-Pietsc ...
Ohlsson, Claes, ...
Orwoll, E.S.
Pasco, J.A.
Rivadeneira, F.
Schei, B.
Schott, A.-M.
Shiroma, E.J.
Siggeirsdottir, ...
Simonsick, E.M.
Sornay-Rendu, E.
Sund, R.
Swart, K.M.A.
Szulc, P.
Tamaki, J.
Torgerson, D.J.
van Schoor, N.M.
van Staa, T.P.
Vila, J.
Wareham, N.J.
Wright, N.C.
Yoshimura, N.
Zillikens, M.C.
Zwart, M.
Harvey, N.C.
Lorentzon, Matti ...
Leslie, W.D.
Kanis, J.A.
visa färre...
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