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WFRF:(Bizzaro Davide)
 

Sökning: WFRF:(Bizzaro Davide) > Dioxin-like activit...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004016naa a2200421 4500
001oai:lup.lub.lu.se:95c7ee6b-bf61-445b-86f2-8cb7472de330
003SwePub
008160401s2006 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11351522 URI
0247 a https://doi.org/10.1186/1476-069X-5-142 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Long, Manhai4 aut
2451 0a Dioxin-like activities in serum across European and Inuit populations
264 1c 2006
520 a BACKGROUND: Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR). The aim of the present study was to compare the integrated serum level of AhR mediated activity among European and Inuit populations, and evaluate whether the activity was associated to the selected POP markers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE). METHODS: The study included 338 males from Greenland (Inuit's), Sweden, Warsaw (Poland) and Kharkiv (Ukraine). The AhR transactivity of serum extracts alone (AhRag) and competitive AhR activity (AhRcomp) upon co-exposure with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were determined in the lipophilic serum fraction containing the POPs using the AhR mediated luciferase reporter Hepa1.12cR cell assay. RESULTS: The European groups showed higher median level of AhR-TEQ (TCDD toxic equivalents) compared to the Inuit's, whereas higher incidence of Inuits sample further induced AhRcomp activity. Neither AhRag nor AhR-TEQ were correlated to CB-153 or p,p'-DDE for any of the study groups. Multiple regressions showed a significant heterogeneity of association between the CB-153 and the AhRcomp across the study groups, and accordingly a negative association between AhRcomp and CB-153 was found for the Kharkiv group. CONCLUSION: No consistent correlation between AhR activities and two POP markers was found. Although the difference of AhRag between European and Inuit men could not be explained by CB-153 or p,p'-DDE levels alone, we believe that the variation of AhR serum activity reflects different pattern of POP exposure, genetics and/or life style factors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
7001 a Andersen, Birgitte S4 aut
7001 a Lindh, Christianu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-cli
7001 a Hagmar, Lars4 aut
7001 a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-agi
7001 a Manicardi, Gian-Carlo4 aut
7001 a Bizzaro, Davide4 aut
7001 a Spano, Marcello4 aut
7001 a Toft, Gunnar4 aut
7001 a Pedersen, Henning S4 aut
7001 a Zvyezday, Valentyna4 aut
7001 a Bonde, Jens Peter4 aut
7001 a Bonefeld-Jorgensen, Eva C4 aut
7102 a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org
7730 t Environmental Healthg 5:14q 5:14x 1476-069X
8564 u http://dx.doi.org/10.1186/1476-069X-5-14y FULLTEXT
8564 8u https://lup.lub.lu.se/record/1135152
8564 8u https://doi.org/10.1186/1476-069X-5-14

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