SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Broeckling Corey D.)
 

Sökning: WFRF:(Broeckling Corey D.) > A Multi-Cohort Meta...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005481naa a2200565 4500
001oai:DiVA.org:uu-402618
003SwePub
008200117s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:142691365
009oai:DiVA.org:du-31198
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4026182 URI
0247 a https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.1044762 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1426913652 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-311982 URI
040 a (SwePub)uud (SwePub)kid (SwePub)du
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lind, Larsu Karolinska Institutet,Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind
2451 0a A Multi-Cohort Metabolomics Analysis Discloses Sphingomyelin (32:1) Levels to be Inversely Related to Incident Ischemic Stroke
264 1b Elsevier BV,c 2020
338 a print2 rdacarrier
520 a Background and Purpose:To search for novel pathophysiological pathways related to ischemic stroke using a metabolomics approach.Methods: We identified 204 metabolites in plasma by liquid chromatography mass spectrometry in 3 independent population-based samples (TwinGene, Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) and Uppsala Longitudinal Study of Adult Men). TwinGene was used for discovery and the other 2 samples were meta-analyzed as replication. In PIVUS, traditional cardiovascular (CV) risk factors, multiple markers of subclinical CV disease, markers of coagulation/fibrinolysis were measured and analyzed in relation to top metabolites.Results:In TwinGene (177 incident cases, median follow-up 4.3 years), levels of 28 metabolites were associated with incident ischemic stroke at a false discover rate (FDR) of 5%. In the replication (together 194 incident cases, follow-up 10 and 12 years, respectively), only sphingomyelin (32:1) was significantly associated (HR.69 per SD change, 95% CI.57-0.83, P value = .00014; FDR <5%) when adjusted for systolic blood pressure, diabetes, smoking, low density lipoportein (LDL)- and high density lipoprotein (HDL), body mass index (BMI) and atrial fibrillation. In PIVUS, sphingomyelin (32:1) levels were significantly related to both LDL- and HDL-cholesterol in a positive fashion, and to serum triglycerides, BMI and diabetes in a negative fashion. Furthermore, sphingomyelin (32:1) levels were related to vasodilation in the forearm resistance vessels, and inversely to leukocyte count (P < .0069 and .0026, respectively).Conclusions:An inverse relationship between sphingomyelin (32:1) and incident ischemic stroke was identified, replicated, and characterized. A possible protective role for sphingomyelins in stroke development has to be further investigated in additional experimental and clinical studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Epidemiology
653 a metabolomics
653 a stroke
653 a risk factor
653 a Hälsa och välfärd
7001 a Salihovic, Samirau Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)samsa560
7001 a Ganna, Andreau Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA4 aut
7001 a Sundström, Johan,c Professor,d 1971-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk epidemiologi4 aut0 (Swepub:uu)johasund
7001 a Broeckling, Corey D.u Colorado State Univ, Prote & Metabol Facil, Ft Collins, CO 80523 USA4 aut
7001 a Magnusson, Patrik K.u Karolinska Institutet4 aut
7001 a Pedersen, Nancy L.u Karolinska Inst, Dept Med Epidemiol & Biostat MEB, Stockholm, Sweden4 aut
7001 a Siegbahn, Agneta,d 1947-u Uppsala universitet,Koagulation och inflammationsvetenskap4 aut0 (Swepub:uu)agsie424
7001 a Prenni, Jessicau Colorado State Univ, Prote & Metabol Facil, Ft Collins, CO 80523 USA4 aut
7001 a Fall, Tove,d 1979-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi4 aut0 (Swepub:uu)tovfa878
7001 a Ingelsson, Eriku Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA;Stanford Cardiovasc Inst, Stanford, CA USA4 aut
7001 a Ärnlöv, Johan,d 1970-u Högskolan Dalarna,Karolinska Institutet,Medicinsk vetenskap4 aut0 (Swepub:du)jan
7102 a Uppsala universitetb Klinisk epidemiologi4 org
7730 t Journal of Stroke & Cerebrovascular Diseasesd : Elsevier BVg 29:2q 29:2x 1052-3057x 1532-8511
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-402618
8564 8u https://doi.org/10.1016/j.jstrokecerebrovasdis.2019.104476
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:142691365
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-31198

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy