Sökning: WFRF:(Buckland P.) > Biomarkers of folat...
Fältnamn | Indikatorer | Metadata |
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000 | 04674naa a2200877 4500 | |
001 | oai:DiVA.org:umu-133193 | |
003 | SwePub | |
008 | 170413s2017 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:135257350 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1331932 URI |
024 | 7 | a https://doi.org/10.1002/ijc.305362 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1352573502 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Matejcic, M.4 aut |
245 | 1 0 | a Biomarkers of folate and vitamin B12 and breast cancer risk :b report from the EPIC cohort |
264 | c 2017-01-27 | |
264 | 1 | b Wiley,c 2017 |
338 | a print2 rdacarrier | |
520 | a Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1=1.26; 95% CI 1.00-1.58; P-trend=0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1=1.29; 95% CI 1.02-162; P-trend=0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a plasma biomarkers | |
653 | a folate | |
653 | a vitamin B12 | |
653 | a alcohol | |
653 | a hormone receptor status | |
653 | a MTHFR polymorphism | |
653 | a east cancer | |
700 | 1 | a de Batlle, J.4 aut |
700 | 1 | a Ricci, C.4 aut |
700 | 1 | a Biessy, C.4 aut |
700 | 1 | a Perrier, F.4 aut |
700 | 1 | a Huybrechts, I.4 aut |
700 | 1 | a Weiderpass, E.u Karolinska Institutet4 aut |
700 | 1 | a Boutron-Ruault, M. C.4 aut |
700 | 1 | a Cadeau, C.4 aut |
700 | 1 | a His, M.4 aut |
700 | 1 | a Cox, D. G.4 aut |
700 | 1 | a Boeing, H.4 aut |
700 | 1 | a Fortner, R. T.4 aut |
700 | 1 | a Kaaks, R.4 aut |
700 | 1 | a Lagiou, P.4 aut |
700 | 1 | a Trichopoulou, A.4 aut |
700 | 1 | a Benetou, V.4 aut |
700 | 1 | a Tumino, R.4 aut |
700 | 1 | a Panico, S.4 aut |
700 | 1 | a Sieri, S.4 aut |
700 | 1 | a Palli, D.4 aut |
700 | 1 | a Ricceri, F.4 aut |
700 | 1 | a Bueno-de-Mesquita, H. B(as)4 aut |
700 | 1 | a Skeie, G.4 aut |
700 | 1 | a Amiano, P.4 aut |
700 | 1 | a Sanchez, M. J.4 aut |
700 | 1 | a Chirlaque, M. D.4 aut |
700 | 1 | a Barricarte, A.4 aut |
700 | 1 | a Quiros, J. R.4 aut |
700 | 1 | a Buckland, G.4 aut |
700 | 1 | a van Gils, C. H.4 aut |
700 | 1 | a Peeters, P. H.4 aut |
700 | 1 | a Key, T. J.4 aut |
700 | 1 | a Riboli, E.4 aut |
700 | 1 | a Gylling, Björnu Umeå universitet,Patologi4 aut0 (Swepub:umu)bjgy0001 |
700 | 1 | a Zeleniuch-Jacquotte, A.4 aut |
700 | 1 | a Gunter, M. J.4 aut |
700 | 1 | a Romieu, I.4 aut |
700 | 1 | a Chajes, V.4 aut |
710 | 2 | a Karolinska Institutetb Patologi4 org |
773 | 0 | t International Journal of Cancerd : Wileyg 140:6, s. 1246-1259q 140:6<1246-1259x 0020-7136x 1097-0215 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30536 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133193 |
856 | 4 8 | u https://doi.org/10.1002/ijc.30536 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135257350 |
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