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Sökning: WFRF:(Buckland P.) > Biomarkers of folat...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004674naa a2200877 4500
001oai:DiVA.org:umu-133193
003SwePub
008170413s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:135257350
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1331932 URI
024a https://doi.org/10.1002/ijc.305362 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1352573502 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Matejcic, M.4 aut
2451 0a Biomarkers of folate and vitamin B12 and breast cancer risk :b report from the EPIC cohort
264 c 2017-01-27
264 1b Wiley,c 2017
338 a print2 rdacarrier
520 a Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1=1.26; 95% CI 1.00-1.58; P-trend=0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1=1.29; 95% CI 1.02-162; P-trend=0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a plasma biomarkers
653 a folate
653 a vitamin B12
653 a alcohol
653 a hormone receptor status
653 a MTHFR polymorphism
653 a east cancer
700a de Batlle, J.4 aut
700a Ricci, C.4 aut
700a Biessy, C.4 aut
700a Perrier, F.4 aut
700a Huybrechts, I.4 aut
700a Weiderpass, E.u Karolinska Institutet4 aut
700a Boutron-Ruault, M. C.4 aut
700a Cadeau, C.4 aut
700a His, M.4 aut
700a Cox, D. G.4 aut
700a Boeing, H.4 aut
700a Fortner, R. T.4 aut
700a Kaaks, R.4 aut
700a Lagiou, P.4 aut
700a Trichopoulou, A.4 aut
700a Benetou, V.4 aut
700a Tumino, R.4 aut
700a Panico, S.4 aut
700a Sieri, S.4 aut
700a Palli, D.4 aut
700a Ricceri, F.4 aut
700a Bueno-de-Mesquita, H. B(as)4 aut
700a Skeie, G.4 aut
700a Amiano, P.4 aut
700a Sanchez, M. J.4 aut
700a Chirlaque, M. D.4 aut
700a Barricarte, A.4 aut
700a Quiros, J. R.4 aut
700a Buckland, G.4 aut
700a van Gils, C. H.4 aut
700a Peeters, P. H.4 aut
700a Key, T. J.4 aut
700a Riboli, E.4 aut
700a Gylling, Björnu Umeå universitet,Patologi4 aut0 (Swepub:umu)bjgy0001
700a Zeleniuch-Jacquotte, A.4 aut
700a Gunter, M. J.4 aut
700a Romieu, I.4 aut
700a Chajes, V.4 aut
710a Karolinska Institutetb Patologi4 org
773t International Journal of Cancerd : Wileyg 140:6, s. 1246-1259q 140:6<1246-1259x 0020-7136x 1097-0215
856u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.30536
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133193
8564 8u https://doi.org/10.1002/ijc.30536
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135257350

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