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FältnamnIndikatorerMetadata
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0247 a https://doi.org/10.3390/jcm90102652 DOI
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041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nilsson, Erik,d 1975-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,School of Medical Sciences, Örebro University, 70182 Örebro, Sweden.4 aut0 (Swepub:oru)eans
2451 0a Pregnancy Associated Plasma Protein-A as a Cardiovascular Risk Marker in Patients with Stable Coronary Heart Disease During 10 Years Follow-Up-A CLARICOR Trial Sub-Study
264 c 2020-01-18
264 1b MDPI,c 2020
338 a print2 rdacarrier
500 a Funding Agencies:Copenhagen Trial Unit, Centre for Clinical Intervention Research  Danish Heart Foundation  01-1-5-21-22894 99-2-5-103-22773 99-1-5-87-22712 97-2-5-70-22537Copenhagen Hospital Corporation  Det Frie Forskningsrad (DFF) 9702122 22-00-0261The 1991 Pharmacy Foundation  HPN/ld/71-97Copenhagen Trial Unit 
520 a Elevated pregnancy-associated plasma protein A (PAPP-A) is associated with mortality in acute coronary syndromes. Few studies have assessed PAPP-A in stable coronary artery disease (CAD) and results are conflicting. We assessed the 10-year prognostic relevance of PAPP-A levels in stable CAD. The CLARICOR trial was a randomized controlled clinical trial including outpatients with stable CAD, randomized to clarithromycin versus placebo. The placebo group constituted our discovery cohort (n = 1.996) and the clarithromycin group the replication cohort (n = 1.975). The composite primary outcome was first occurrence of cardiovascular event or death. In the discovery cohort, incidence rates (IR) for the composite outcome were higher in those with elevated PAPP-A (IR 12.72, 95% Confidence Interval (CI) 11.0-14.7 events/100 years) compared to lower PAPP-A (IR 8.78, 8.25-9.34), with comparable results in the replication cohort. Elevated PAPP-A was associated with increased risk of the composite outcome in both cohorts (discovery Hazard Ratio (HR) 1.45, 95% CI 1.24-1.70; replication HR 1.29, 95% CI 1.10-1.52). In models adjusted for established risk factors, these trends were attenuated. Elevated PAPP-A was associated with higher all-cause mortality in both cohorts. We conclude that elevated PAPP-A levels are associated with increased long-term mortality in stable CAD, but do not improve long-term prediction of death or cardiovascular events when added to established predictors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a pregnancy-associated plasma protein-A
653 a coronary artery disease
653 a cohort studies
653 a biomarkers
653 a Health and Welfare
7001 a Kastrup, Jensu Department of Cardiology, Rigshospitalet University of Copenhagen, 2100 Copenhagen, Denmark.4 aut
7001 a Sajadieh, Ahmadu Department of Cardiology, Copenhagen University Hospital of Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark.4 aut
7001 a Jensen, Gorm Bojeu Department of Cardiology, Hvidovre Hospital University of Copenhagen, 2650 Hvidovre, Denmark.4 aut
7001 a Kjøller, Eriku Department of Cardiology S, Herlev Hospital University of Copenhagen, Herlev, Denmark; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut
7001 a Kolmos, Hans Jørnu Department of Clinical Microbiology, Odense University Hospital, 5000 Odense, Denmark.4 aut
7001 a Wuopio, Jonasu Department of Medicine, Mora County Hospital, 79251 Mora, Sweden.4 aut
7001 a Nowak, Christophu Karolinska Institutet4 aut
7001 a Larsson, Andersu Karolinska Institutet,Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)andlarss
7001 a Jakobsen, Janus Christianu Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Cardiology, Holbæk Hospital, Holbæk, Denmark,Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut
7001 a Winkel, Peru Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut
7001 a Gluud, Christianu Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.4 aut
7001 a Iversen, Kasper K.u Department of Cardiology S, Herlev Hospital University of Copenhagen, 2730 Herlev, Denmark.4 aut
7001 a Ärnlöv, Johan,d 1970-u Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden.4 aut0 (Swepub:du)jan
7001 a Carlsson, Axel C.u Division for Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 14183 Huddinge, Sweden.4 aut
7102 a Örebro universitetb Institutionen för medicinska vetenskaper4 org
7730 t Journal of Clinical Medicined : MDPIg 9:1q 9:1x 2077-0383
8564 u https://doi.org/10.3390/jcm9010265y Fulltext
8564 u https://www.mdpi.com/2077-0383/9/1/265/pdf
8564 u https://du.diva-portal.org/smash/get/diva2:1388967/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://uu.diva-portal.org/smash/get/diva2:1390634/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-80677
8564 8u https://doi.org/10.3390/jcm9010265
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-31734
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-403679
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143056686

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