WFRF:(Castagnoli P)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04553naa a2201057 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:151316233 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1513162332 URI |
| 024 | 7 | a https://doi.org/10.1084/jem.202205142 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhang, Q4 aut |
| 245 | 1 0 | a Autoantibodies against type I IFNs in patients with critical influenza pneumonia |
| 264 | c 2022-09-16 | |
| 264 | 1 | b Rockefeller University Press,c 2022 |
| 520 | a Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-α2 alone (five patients) or with IFN-ω (eight patients) from a cohort of 279 patients (4.7%) aged 6–73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-α2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-ω. The patients’ autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 × 10−5), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-α2 and IFN-ω (OR = 11.7, P = 1.3 × 10−5), especially those <70 yr old (OR = 139.9, P = 3.1 × 10−10). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for ∼5% of cases of life-threatening influenza pneumonia in patients <70 yr old. | |
| 700 | 1 | a Pizzorno, A4 aut |
| 700 | 1 | a Miorin, L4 aut |
| 700 | 1 | a Bastard, P4 aut |
| 700 | 1 | a Gervais, A4 aut |
| 700 | 1 | a Le Voyer, T4 aut |
| 700 | 1 | a Bizien, L4 aut |
| 700 | 1 | a Manry, J4 aut |
| 700 | 1 | a Rosain, J4 aut |
| 700 | 1 | a Philippot, Q4 aut |
| 700 | 1 | a Goavec, K4 aut |
| 700 | 1 | a Padey, B4 aut |
| 700 | 1 | a Cupic, A4 aut |
| 700 | 1 | a Laurent, E4 aut |
| 700 | 1 | a Saker, K4 aut |
| 700 | 1 | a Vanker, M4 aut |
| 700 | 1 | a Sarekannu, K4 aut |
| 700 | 1 | a Garcia-Salum, T4 aut |
| 700 | 1 | a Ferres, M4 aut |
| 700 | 1 | a Le Corre, N4 aut |
| 700 | 1 | a Sanchez-Cespedes, J4 aut |
| 700 | 1 | a Balsera-Manzanero, M4 aut |
| 700 | 1 | a Carratala, J4 aut |
| 700 | 1 | a Retamar-Gentil, P4 aut |
| 700 | 1 | a Abelenda-Alonso, G4 aut |
| 700 | 1 | a Valiente, A4 aut |
| 700 | 1 | a Tiberghien, P4 aut |
| 700 | 1 | a Zins, M4 aut |
| 700 | 1 | a Debette, S4 aut |
| 700 | 1 | a Meyts, I4 aut |
| 700 | 1 | a Haerynck, F4 aut |
| 700 | 1 | a Castagnoli, R4 aut |
| 700 | 1 | a Notarangelo, LD4 aut |
| 700 | 1 | a Gonzalez-Granado, LI4 aut |
| 700 | 1 | a Dominguez-Pinilla, N4 aut |
| 700 | 1 | a Andreakos, E4 aut |
| 700 | 1 | a Triantafyllia, V4 aut |
| 700 | 1 | a Rodriguez-Gallego, C4 aut |
| 700 | 1 | a Sole-Violan, J4 aut |
| 700 | 1 | a Ruiz-Hernandez, JJ4 aut |
| 700 | 1 | a Rodriguez de Castro, F4 aut |
| 700 | 1 | a Ferreres, J4 aut |
| 700 | 1 | a Briones, M4 aut |
| 700 | 1 | a Wauters, J4 aut |
| 700 | 1 | a Vanderbeke, L4 aut |
| 700 | 1 | a Feys, S4 aut |
| 700 | 1 | a Kuo, CY4 aut |
| 700 | 1 | a Lei, WT4 aut |
| 700 | 1 | a Ku, CL4 aut |
| 700 | 1 | a Tal, G4 aut |
| 700 | 1 | a Etzioni, A4 aut |
| 700 | 1 | a Hanna, S4 aut |
| 700 | 1 | a Fournet, T4 aut |
| 700 | 1 | a Casalegno, JS4 aut |
| 700 | 1 | a Queromes, G4 aut |
| 700 | 1 | a Argaud, L4 aut |
| 700 | 1 | a Javouhey, E4 aut |
| 700 | 1 | a Rosa-Calatrava, M4 aut |
| 700 | 1 | a Cordero, E4 aut |
| 700 | 1 | a Aydillo, T4 aut |
| 700 | 1 | a Medina, RA4 aut |
| 700 | 1 | a Kisand, K4 aut |
| 700 | 1 | a Puel, A4 aut |
| 700 | 1 | a Jouanguy, E4 aut |
| 700 | 1 | a Abel, L4 aut |
| 700 | 1 | a Cobat, A4 aut |
| 700 | 1 | a Trouillet-Assant, S4 aut |
| 700 | 1 | a Garcia-Sastre, A4 aut |
| 700 | 1 | a Casanova, JL4 aut |
| 773 | 0 | t The Journal of experimental medicined : Rockefeller University Pressg 219:11q 219:11x 1540-9538x 0022-1007 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:151316233 |
| 856 | 4 8 | u https://doi.org/10.1084/jem.20220514 |
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- Zhang, Q
- Pizzorno, A
- Miorin, L
- Bastard, P
- Gervais, A
- Le Voyer, T
- visa fler...
- Bizien, L
- Manry, J
- Rosain, J
- Philippot, Q
- Goavec, K
- Padey, B
- Cupic, A
- Laurent, E
- Saker, K
- Vanker, M
- Sarekannu, K
- Garcia-Salum, T
- Ferres, M
- Le Corre, N
- Sanchez-Cespedes ...
- Balsera-Manzaner ...
- Carratala, J
- Retamar-Gentil, ...
- Abelenda-Alonso, ...
- Valiente, A
- Tiberghien, P
- Zins, M
- Debette, S
- Meyts, I
- Haerynck, F
- Castagnoli, R
- Notarangelo, LD
- Gonzalez-Granado ...
- Dominguez-Pinill ...
- Andreakos, E
- Triantafyllia, V
- Rodriguez-Galleg ...
- Sole-Violan, J
- Ruiz-Hernandez, ...
- Rodriguez de Cas ...
- Ferreres, J
- Briones, M
- Wauters, J
- Vanderbeke, L
- Feys, S
- Kuo, CY
- Lei, WT
- Ku, CL
- Tal, G
- Etzioni, A
- Hanna, S
- Fournet, T
- Casalegno, JS
- Queromes, G
- Argaud, L
- Javouhey, E
- Rosa-Calatrava, ...
- Cordero, E
- Aydillo, T
- Medina, RA
- Kisand, K
- Puel, A
- Jouanguy, E
- Abel, L
- Cobat, A
- Trouillet-Assant ...
- Garcia-Sastre, A
- Casanova, JL
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