Sökning: WFRF:(Chen Nancy) > (2010-2014) > Association analyse...
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000 | 19679naa a2205029 4500 | |
001 | oai:DiVA.org:uu-134102 | |
003 | SwePub | |
008 | 101122s2010 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:e9b5a2fa-c736-40eb-a097-82d3accf364d | |
009 | oai:gup.ub.gu.se/127911 | |
009 | oai:prod.swepub.kib.ki.se:121530056 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1341022 URI |
024 | 7 | a https://doi.org/10.1038/ng.6862 DOI |
024 | 7 | a https://lup.lub.lu.se/record/17189422 URI |
024 | 7 | a https://gup.ub.gu.se/publication/1279112 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1215300562 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)gud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Speliotes, Elizabeth K.4 aut |
245 | 1 0 | a Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index |
264 | c 2010-10-10 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
338 | a print2 rdacarrier | |
500 | a De sju sista författarna delar sistaförfattarskapet. | |
520 | a Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Willer, Cristen J.4 aut |
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700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal |
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700 | 1 | a Igl, Wilmaru Uppsala universitet,Institutionen för genetik och patologi4 aut |
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700 | 1 | a Jacobs, Kevin B.4 aut |
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700 | 1 | a Boehnke, Michael4 aut |
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700 | 1 | a McCarthy, Mark I.4 aut |
700 | 1 | a Hirschhorn, Joel N.4 aut |
700 | 1 | a Ingelsson, Eriku Karolinska Institutet4 aut |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a Gräßler, Jürgen4 aut |
710 | 2 | a Uppsala universitetb Institutionen för genetik och patologi4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 42:11, s. 937-948q 42:11<937-948x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc3014648?pdf=render |
856 | 4 | u http://dx.doi.org/10.1038/ng.686y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134102 |
856 | 4 8 | u https://doi.org/10.1038/ng.686 |
856 | 4 8 | u https://lup.lub.lu.se/record/1718942 |
856 | 4 8 | u https://gup.ub.gu.se/publication/127911 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121530056 |
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