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Amyloid-like amelog...
Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites
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- Akkineni, Susrut (författare)
- University of Washington, Seattle,Pacific Northwest National Laboratory
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- Zhu, Cheng (författare)
- University of Colorado at Boulder
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- Chen, Jiajun (författare)
- University of Washington, Seattle,Pacific Northwest National Laboratory
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visa fler...
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- Song, Miao (författare)
- Pacific Northwest National Laboratory,University of Washington, Seattle
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- Hoff, Samuel E. (författare)
- University of Colorado at Boulder
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- Bonde, Johan (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Tao, Jinhui (författare)
- Jordan University of Science and Technology,Pacific Northwest National Laboratory
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- Heinz, Hendrik (författare)
- University of Colorado at Boulder
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- Habelitz, Stefan (författare)
- University of California, San Francisco
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- De Yoreo, James J. (författare)
- University of Washington, Seattle,Pacific Northwest National Laboratory
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(creator_code:org_t)
- 2022-05-06
- 2022
- Engelska 10 s.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:19
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Protein scaffolds direct the organization of amorphous precursors that transform into mineralized tissues, but the templating mechanism remains elusive. Motivated by models for the biomineralization of tooth enamel, wherein amyloid-like amelogenin nanoribbons guide the mineralization of apatite filaments, we investigated the impact of nanoribbon structure, sequence, and chemistry on amorphous calcium phosphate (ACP) nucleation. Using full-length human amelogenin and peptide analogs with an amyloid-like domain, films of β-sheet nanoribbons were self-assembled on graphite and characterized by in situ atomic force microscopy and molecular dynamics simulations. All sequences substantially reduce nucleation barriers for ACP by creating low-energy interfaces, while phosphoserines along the length of the nanoribbons dramatically enhance kinetic factors associated with ion binding. Furthermore, the distribution of negatively charged residues along the nanoribbons presents a potential match to the Ca–Ca distances of the multi-ion complexes that constitute ACP. These findings show that amyloid-like amelogenin nanoribbons provide potent scaffolds for ACP mineralization by presenting energetically and stereochemically favorable templates of calcium phosphate ion binding and suggest enhanced surface wetting toward calcium phosphates in general.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Amelogenin/chemistry
- Amyloidogenic Proteins
- Binding Sites
- Calcium Phosphates
- Dental Enamel Proteins
- Nanotubes, Carbon
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Akkineni, Susrut
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Zhu, Cheng
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Chen, Jiajun
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Song, Miao
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Hoff, Samuel E.
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Bonde, Johan
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visa fler...
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Tao, Jinhui
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Heinz, Hendrik
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Habelitz, Stefan
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De Yoreo, James ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Odontologi
- Artiklar i publikationen
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Proceedings of t ...
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Proceedings of t ...
- Av lärosätet
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Lunds universitet