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Sökning: WFRF:(Christensson Anders) > (2015-2019) > Longitudinal Assess...

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FältnamnIndikatorerMetadata
00004945naa a2200409 4500
001oai:lup.lub.lu.se:a7f56d55-0291-49c6-855b-f5e26ce45420
003SwePub
008180102s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:229264515
0247 a https://lup.lub.lu.se/record/a7f56d55-0291-49c6-855b-f5e26ce454202 URI
0247 a https://doi.org/10.1210/js.2017-001042 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2292645152 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Buchebner, Davidu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Halmstad County Hospital,Skåne University Hospital4 aut0 (Swepub:lu)med-dbc
2451 0a Longitudinal Assessment of PTH in Community-Dwelling Older Women-Elevations Are Not Associated With Mortality
264 c 2017-04-19
264 1b The Endocrine Society,c 2017
520 a Context: In older women, the magnitude of elevated parathyroid hormone (PTH) and its consequence is unclear.Objective: To describe normal PTH profiles over time and the association with mortality.Design and Participants: There were 1044 community-dwelling women in the Malmö Osteoporosis Prospective Risk Assessment cohort (OPRA) who attended baseline (age 75 years). Follow-ups were attended by 715 (age 80 years) and 382 (age 85 years).Main Outcome Measures: PTH, estimated glomerular filtration rate (eGFR), 25-hydroxyvitamin D (25OHD) and mortality.Results: At age 75 years, PTH levels for most (n = 877, 88%) were within the normal reference range (NRR) (i.e., <6.9 pmol/L). Longitudinally, between ages 75 and 80 years, PTH increased in 60% of all women (n = 390) but increases of up to 50% above baseline values (64%; n=250) still resulted in PTH levels within the NRR. These women had lower 25OHD levels (74 vs 83 nmol/L, P = 0.001). Only when increases were >50% was PTH elevated beyond the NRR (mean 7.1 ± 3.3). Here, a pronounced decline in eGFR (56 vs 61 mL/min/1.73 m2, P = 0.002) was found, despite no further changes in 25OHD. Extending the observational period until age 85 years gave similar results. Baseline PTH levels above NRR were associated with mortality (hazard ratio, 1.4; 95% confidence interval (CI), 1.1-1.8; P = 0.007), although not after adjustment for covariates (P = 0.082).Conclusions: Most women remained within normal PTH ranges despite large increases of up to 50%. PTH elevated above normal is not independently associated with mortality; impaired kidney function and low 25OHD status may be more prognostic in the very old.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng
7001 a Malmgren, Linneau Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-lam
7001 a Christensson, Andersu Skåne University Hospital4 aut0 (Swepub:lu)medf-ach
7001 a McGuigan, Fionau Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-fam
7001 a Gerdhem, Paulu Karolinska Institutet,Karolinska Institute4 aut0 (Swepub:lu)orto-pge
7001 a Ridderstråle, Martinu Skåne University Hospital4 aut0 (Swepub:lu)endo-mri
7001 a Åkesson, Kristinau Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)orto-kak
7102 a Ortopedi - klinisk och molekylär osteoporosforskningb Forskargrupper vid Lunds universitet4 org
7730 t Journal of the Endocrine Societyd : The Endocrine Societyg 1:6, s. 615-624q 1:6<615-624x 2472-1972
8564 u http://dx.doi.org/10.1210/js.2017-00104x freey FULLTEXT
8564 u https://academic.oup.com/jes/article-pdf/1/6/615/17505518/js.2017-00104.pdf
8564 8u https://lup.lub.lu.se/record/a7f56d55-0291-49c6-855b-f5e26ce45420
8564 8u https://doi.org/10.1210/js.2017-00104
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:229264515

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