Sökning: WFRF:(Colombel Jean Frederic) > (2020-2024) > Human Leukocyte Ant...
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000 | 10346naa a2201021 4500 | |
001 | oai:lup.lub.lu.se:8ee4455e-30c9-4ed5-b985-fd248c7f5cbb | |
003 | SwePub | |
008 | 240320s2024 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:153972347 | |
009 | oai:DiVA.org:liu-198977 | |
024 | 7 | a https://lup.lub.lu.se/record/8ee4455e-30c9-4ed5-b985-fd248c7f5cbb2 URI |
024 | 7 | a https://doi.org/10.1093/ecco-jcc/jjad1652 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1539723472 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1989772 URI |
040 | a (SwePub)lud (SwePub)kid (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Zheng, Tenghaou Karolinska Institute,Monash University,Monash Univ, Australia; Karolinska Inst, Sweden4 aut |
245 | 1 0 | a Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes |
264 | 1 | b OXFORD UNIV PRESS,c 2024 |
300 | a 11 s. | |
500 | a Funding Agencies|Swedish Research Council [VR 2017-02403] | |
520 | a Background and Aims: Microscopic colitis [MC] is currently regarded as an inflammatory bowel disease that manifests as two subtypes: collagenous colitis [CC] and lymphocytic colitis [LC]. Whether these represent a clinical continuum or distinct entities is, however, an open question. Genetic investigations may contribute important insight into their respective pathophysiologies. Methods: We conducted a genome-wide association study [GWAS] meta-analysis in 1498 CC, 373 LC patients, and 13 487 controls from Europe and the USA, combined with publicly available MC GWAS data from UK Biobank and FinnGen [2599 MC cases and 552 343 controls in total]. Human leukocyte antigen [HLA] alleles and polymorphic residues were imputed and tested for association, including conditional analyses for the identification of key causative variants and residues. Genetic correlations with other traits and diagnoses were also studied. Results: We detected strong HLA association with CC, and conditional analyses highlighted the DRB1*03:01 allele and its residues Y26, N77, and R74 as key to this association (best p = 1.4 × 10-23, odds ratio [OR] = 1.96). Nominally significant genetic correlations were detected between CC and pneumonia [rg = 0.77; p = 0.048] and oesophageal diseases [rg = 0.45, p = 0.023]. An additional locus was identified in MC GWAS analyses near the CLEC16A and RMI2 genes on chromosome 16 [rs35099084, p = 2.0 × 10-8, OR = 1.31]. No significant association was detected for LC. Conclusion: Our results suggest CC and LC have distinct pathophysiological underpinnings, characterised by an HLA predisposing role only in CC. This challenges existing classifications, eventually calling for a re-evaluation of the utility of MC umbrella definitions. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
653 | a collagenous colitis | |
653 | a genetics | |
653 | a GWAS | |
653 | a HLA | |
653 | a Microscopic colitis | |
653 | a Microscopic colitis; collagenous colitis; GWAS; HLA; genetics | |
700 | 1 | a Roda, Giuliau National Institute Of Biostructures And Biosystems,Biostruct & Biosyst Natl Inst, Italy4 aut |
700 | 1 | a Zabana, Yamileu CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Mutua De Terrassa Hospital,Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain4 aut |
700 | 1 | a Escudero-Hernández, Celiau Linköpings universitet,Linköping University,University of Kiel,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Univ Kiel, Germany; Univ Med Ctr Schleswig Holstein, Germany4 aut0 (Swepub:liu)celes93 |
700 | 1 | a Liu, Xingrongu Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden4 aut |
700 | 1 | a Chen, Yeu Massachusetts General Hospital,Massachusetts Gen Hosp, MA USA4 aut |
700 | 1 | a Tavares, Leticia Camargou Monash University,Monash Univ, Australia4 aut |
700 | 1 | a Bonfiglio, Ferdinandou Karolinska Institute,Monash University,Monash Univ, Australia; Karolinska Inst, Sweden4 aut |
700 | 1 | a Mellander, Marie Roseu Skåne University Hospital,Lund Univ, Sweden4 aut |
700 | 1 | a Janczewska, Izabellau Ersta Hospital,Ersta Hosp, Sweden4 aut |
700 | 1 | a Vigren, Linau Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Lund Univ, Sweden4 aut0 (Swepub:lu)med-lvi |
700 | 1 | a Sjöberg, Klasu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,LTH profilområde: Avancerade ljuskällor,LTH profilområden,Lunds Tekniska Högskola,LU profilområde: Ljus och material,Lunds universitets profilområden,Gastroenterology,Lund University Research Groups,LTH Profile Area: Photon Science and Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)medf-ksj |
700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden4 aut0 (Swepub:lu)kir-boh |
700 | 1 | a Almer, Svenu Karolinska Institutet,Karolinska Univ Hosp, Sweden,Karolinska University Hospital4 aut |
700 | 1 | a Halfvarson, Jonasu Örebro University Hospital,Orebro Univ Hosp, Sweden4 aut |
700 | 1 | a Miehlke, Stephanu University Medical Center Hamburg-Eppendorf,Univ Hosp Eppendorf, Germany4 aut |
700 | 1 | a Madisch, Ahmedu CRH Clin Siloah, Germany4 aut |
700 | 1 | a Lieb, Wolfgangu University of Kiel,Christian Albrechts Univ Kiel, Germany4 aut |
700 | 1 | a Kupčinskas, Juozasu Lithuanian University of Health Sciences,Lithuanian Univ Hlth Sci, Lithuania4 aut |
700 | 1 | a Weersma, Rinse K.u University Medical Center Groningen,Univ Groningen, Netherlands; Univ Med Ctr Groningen, Netherlands4 aut |
700 | 1 | a Bujanda, Luisu CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Hospital Universitario Donostia,Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain; Donostia University Hospital, Spain4 aut |
700 | 1 | a Julià, Antoniou Vall d'Hebron University Hospital,Vall Hebron Res Inst, Spain4 aut |
700 | 1 | a Marsal, Sarau Vall d'Hebron University Hospital,Vall Hebron Res Inst, Spain4 aut |
700 | 1 | a Esteve, Mariau Mutua De Terrassa Hospital,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain4 aut |
700 | 1 | a Guagnozzi, Danilau Vall d'Hebron University Hospital,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain; Vall Hebron Univ Hosp, Spain4 aut |
700 | 1 | a Fernández-Bañares, Fernandou Mutua De Terrassa Hospital,CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd),Hosp Univ Mutua Terrassa, Spain; Ctr Invest Biomed Red Enfermedades Hepat & Digest, Spain4 aut |
700 | 1 | a Ferrer, Carmenu Mutua De Terrassa Hospital,Hosp Univ Mutua Terrassa, Spain4 aut |
700 | 1 | a Peter, Ingau Icahn School of Medicine at Mount Sinai,Icahn Sch Med Mt Sinai, NY USA4 aut |
700 | 1 | a Ludvigsson, Jonas F.u Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden4 aut |
700 | 1 | a Pardi, Darrellu Mayo Clinic Minnesota,Mayo Clin, MN USA4 aut |
700 | 1 | a Verhaegh, Basu Maastricht University,Maastricht Univ, Netherlands4 aut |
700 | 1 | a Jonkers, Daisyu Maastricht University,Maastricht Univ, Netherlands4 aut |
700 | 1 | a Pierik, Mariekeu Maastricht University,Maastricht Univ, Netherlands4 aut |
700 | 1 | a Münch, Andreasu Linköpings universitet,Linköping University,Center For Cooperative Research In Biosciences (CIC bioGUNE),Avdelningen för molekylär medicin och virologi,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)andsa76 |
700 | 1 | a Franke, Andreu University of Kiel,Univ Kiel, Germany4 aut |
700 | 1 | a Bresso, Francescau Karolinska Institutet,Karolinska Univ Hosp, Sweden,Karolinska University Hospital4 aut |
700 | 1 | a Khalili, Hamedu Massachusetts General Hospital,Massachusetts Institute of Technology,Massachusetts Gen Hosp, MA USA; Broad Inst Massachusetts Inst Technol & Harvard, MA USA4 aut |
700 | 1 | a Colombel, Jean Fredericu Icahn School of Medicine at Mount Sinai,Icahn Sch Med Mt Sinai, NY USA4 aut |
700 | 1 | a D’Amato, Maurou Karolinska Institute,Basque Foundation for Science,Center For Cooperative Research In Biosciences (CIC bioGUNE),Karolinska Inst, Sweden; CIC bioGUNE BRTA, Spain; Basque Fdn Sci, Spain; LUM Univ, Italy4 aut |
700 | 1 | a Presser, Lance4 aut |
700 | 1 | a Teirlinck, Anne4 aut |
700 | 1 | a Knol, Mirjam4 aut |
700 | 1 | a Piqueras, Martau Consorci Sanitari de Terrassa4 aut |
700 | 1 | a Busquets, Davidu Hospital Universitari de Girona Dr. Josep Trueta4 aut |
700 | 1 | a Iglesias, Evau Hospital Universitario Reina Sofia4 aut |
700 | 1 | a Lucendo, Alfredo J.u CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd)4 aut |
710 | 2 | a Karolinska Instituteb Monash University4 org |
710 | 2 | a MC-Europe GETECCU GWAS group |
773 | 0 | t Journal of Crohn's and Colitisd : OXFORD UNIV PRESSg 18:3, s. 349-359q 18:3<349-359x 1873-9946x 1876-4479 |
856 | 4 | u http://dx.doi.org/10.1093/ecco-jcc/jjad165y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/8ee4455e-30c9-4ed5-b985-fd248c7f5cbb |
856 | 4 8 | u https://doi.org/10.1093/ecco-jcc/jjad165 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153972347 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198977 |
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