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Concordance in Anti...
Concordance in Anti-OmpC and Anti-I2 Indicate the Influence of Genetic Predisposition : Results of a European Study of Twins with Crohn's Disease
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- Amcoff, Karin, 1975- (författare)
- Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Joossens, Marie (författare)
- Department of Microbiology and Immunology, Rega Institute, Katholieke Universiteit, Leuven,Belgium; VIB Center for the Biology of Disease, Leuven, Belgium; Microbiology Unit, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit, Brussels, Belgium
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- Pierik, Marie J. (författare)
- Gastroenterology, University Hospital Maastricht, Maastricht, The Netherlands
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- Jonkers, Daisy (författare)
- Gastroenterology, University Hospital Maastricht, Maastricht, The Netherlands
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- Bohr, Johan, 1957- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Joossens, Sofie (författare)
- Gastroenterology, Catholic University of Leuven (KUL), Leuven, Belgium
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- Romberg-Camps, Mariëlle (författare)
- Department of Gastroenterology-Hepatology, Zuyderland Medical Center, Sittard, Netherlands
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- Nyhlin, Nils, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Wickbom, Anna, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Rutgeerts, Paul J. (författare)
- Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
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- Tysk, Curt (författare)
- Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Bodin, Lennart (författare)
- Karolinska Institutet
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- Colombel, Jean-Frederic (författare)
- Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York NY, USA
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- Vermeire, Severine (författare)
- Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2016-01-27
- 2016
- Engelska.
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Ingår i: Journal of Crohn's & Colitis. - Oxford, United Kingdom : Oxford University Press. - 1873-9946 .- 1876-4479. ; 10:6, s. 695-702
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Aims: An adaptive immunological response to microbial antigens has been observed in Crohn's disease (CD). Intriguingly, this serological response precedes the diagnosis in some patients and has also been observed in healthy relatives. We aimed to determine whether genetic factors are implicated in this response in a CD twin cohort.Methods: In total, 82 twin pairs (Leuven n = 13, Maastricht n = 8, Örebro n = 61) took part: 81 pairs with CD (concordant monozygotic n = 16, discordant monozygotic n = 22, concordant dizygotic n = 3, discordant dizygotic n = 40) and 1 monozygotic pair with both CD and ulcerative colitis. Serology for Pseudomonas fluorescens-related protein (anti-I2), Escherichia coli outer membrane porin C (anti-OmpC), CBir1flagellin (anti-CBir1) and antibodies to oligomannan (anti-Saccharomyces cerevisiae antibody [ASCA]) was determined by standardized enzyme-linked immunoassay.Results: All markers were more often present in CD twins than in their healthy twin siblings. Using the intraclass correlation coefficient (ICC), agreements in concentrations of anti-OmpC and anti-I2 were observed in discordant monozygotic but not in discordant dizygotic twin pairs with CD (anti-OmpC, ICC 0.80 and -0.02, respectively) and (anti-I2, ICC 0.56 and 0.05, respectively). In contrast, no agreements were found in anti-CBir, immunoglobulin (Ig) G ASCA and ASCA IgA.Conclusions: We show that anti-I2 and anti-CBir1 statuses have specificity for CD and confirm previous reported specificities for anti-OmpC and ASCA. Based on quantitative analyses and observed ICCs, genetics seems to predispose to the anti-OmpC and anti-I2 response but less to ASCA and anti-CBir1 responses.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Crohn’s disease
- serology
- genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Amcoff, Karin, 1 ...
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Joossens, Marie
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Pierik, Marie J.
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Jonkers, Daisy
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Bohr, Johan, 195 ...
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Joossens, Sofie
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Romberg-Camps, M ...
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Nyhlin, Nils, 19 ...
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Wickbom, Anna, 1 ...
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Rutgeerts, Paul ...
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Tysk, Curt
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Bodin, Lennart
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Colombel, Jean-F ...
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Vermeire, Severi ...
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Halfvarson, Jona ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Journal of Crohn ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet