Secondary Metabolites from Bolivian Plants- Isolation and Characterization

Davila, Marcelo (författare): Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH

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Abstract Ämnesord

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Nature has been recognized as a rich source of potentially useful chemicals. Throughout the years, phytochemical studies have led to the discovery of an enormous number of natural products, their chemical diversity is unique and many of them possess various biological activities. As a contribution, this thesis presents the results obtained from the phytochemical study of four Bolivian plants. Senecio clivicolus, Prumnopitys exigua, Baccharis polycephala and Podocarpus parlatorei, which all are species that grow naturally in Bolivia. The study is based on the isolation, purification and spectroscopic characterization of secondary metabolites. To achieve this, various chromatographic methods have been applied to the crude plant extracts in order to fractionate them to the point that pure compounds are obtained. Once a natural product is isolated, it was subjected to high-resolution mass spectrometry to determine its elemental composition and NMR spectroscopy to elucidate the molecular structure.

Popular Abstract in English Plants produce an array of organic chemicals with an enormous diversity of structural types. Many of these phytochemicals are biologically active compounds necessary for the well-being, survival, and evolution of the plants, but also have been used by humans, who have used them in traditional medicine and for pharmaceutical industry. During the course of this research, the natural products isolated from four endemic or medicinal plant species of Bolivia are presented, as well as the techniques and processes through which have been isolated and identified. It also contains the biological activities reported in the literature.

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