A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

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Fältnamn	Indikatorer	Metadata
000		06279naa a2201477 4500
001		oai:gup.ub.gu.se/134597
003		SwePub
008		240528s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:120375072
024	7	a https://gup.ub.gu.se/publication/1345972 URI
024	7	a https://doi.org/10.1038/ng.5582 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1203750722 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Kiemeney, Lambertus A4 aut
245	1 0	a A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
264		c 2010-03-28
264	1	b Springer Science and Business Media LLC,c 2010
520		a Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set and tested the top 20 markers from the combined analysis in several European case-control sample sets, with a total of 4,739 cases and 45,549 controls. The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC. Notably, rs798766[T] shows stronger association with low-grade and low-stage UBC than with more aggressive forms of the disease and is associated with higher risk of recurrence in low-grade stage Ta tumors. The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Alleles
653		a Chromosomes
653		a Human
653		a Pair 4
653		a Disease-Free Survival
653		a Europe
653		a Female
653		a Genetic Predisposition to Disease
653		a Genetic Variation
653		a Genotype
653		a Humans
653		a Male
653		a Models
653		a Genetic
653		a Mutation
653		a Receptor
653		a Fibroblast Growth Factor
653		a Type 3
653		a genetics
653		a Recurrence
653		a Risk
653		a Smoking
653		a Urinary Bladder Neoplasms
653		a genetics
700	1	a Sulem, Patrick4 aut
700	1	a Besenbacher, Soren4 aut
700	1	a Vermeulen, Sita H4 aut
700	1	a Sigurdsson, Asgeir4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Gudbjartsson, Daniel F4 aut
700	1	a Stacey, Simon N4 aut
700	1	a Gudmundsson, Julius4 aut
700	1	a Zanon, Carlo4 aut
700	1	a Kostic, Jelena4 aut
700	1	a Masson, Gisli4 aut
700	1	a Bjarnason, Hjordis4 aut
700	1	a Palsson, Stefan T4 aut
700	1	a Skarphedinsson, Oskar B4 aut
700	1	a Gudjonsson, Sigurjon A4 aut
700	1	a Witjes, J Alfred4 aut
700	1	a Grotenhuis, Anne J4 aut
700	1	a Verhaegh, Gerald W4 aut
700	1	a Bishop, D Timothy4 aut
700	1	a Sak, Sei Chung4 aut
700	1	a Choudhury, Ananya4 aut
700	1	a Elliott, Faye4 aut
700	1	a Barrett, Jennifer H4 aut
700	1	a Hurst, Carolyn D4 aut
700	1	a de Verdier, Petra Ju Karolinska Institutet4 aut
700	1	a Ryk, Charlottau Karolinska Institutet4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Gurzau, Eugene4 aut
700	1	a Koppova, Kvetoslava4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Polidoro, Silvia4 aut
700	1	a Guarrera, Simonetta4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Campagna, Marcello4 aut
700	1	a Placidi, Donatella4 aut
700	1	a Arici, Cecilia4 aut
700	1	a Zeegers, Maurice P4 aut
700	1	a Kellen, Eliane4 aut
700	1	a Gutierrez, Berta Saez4 aut
700	1	a Sanz-Velez, José I4 aut
700	1	a Sanchez-Zalabardo, Manuel4 aut
700	1	a Valdivia, Gabriel4 aut
700	1	a Garcia-Prats, Maria D4 aut
700	1	a Hengstler, Jan G4 aut
700	1	a Blaszkewicz, Meinolf4 aut
700	1	a Dietrich, Holger4 aut
700	1	a Ophoff, Roel A4 aut
700	1	a van den Berg, Leonard H4 aut
700	1	a Alexiusdottir, Kristin4 aut
700	1	a Kristjansson, Kristleifur4 aut
700	1	a Geirsson, Gudmunduru Karolinska Institutet4 aut
700	1	a Nikulasson, Sigfus4 aut
700	1	a Petursdottir, Vigdis4 aut
700	1	a Kong, Augustine4 aut
700	1	a Thorgeirsson, Thorgeir4 aut
700	1	a Mungan, N Aydin4 aut
700	1	a Lindblom, Annikau Karolinska Institutet4 aut
700	1	a van Es, Michael A4 aut
700	1	a Porru, Stefano4 aut
700	1	a Buntinx, Frank4 aut
700	1	a Golka, Klaus4 aut
700	1	a Mayordomo, José I4 aut
700	1	a Kumar, Rajiv4 aut
700	1	a Matullo, Giuseppe4 aut
700	1	a Steineck, Gunnar,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xstegu
700	1	a Kiltie, Anne E4 aut
700	1	a Aben, Katja K H4 aut
700	1	a Jonsson, Eirikur4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Knowles, Margaret A4 aut
700	1	a Rafnar, Thorunn4 aut
700	1	a Stefansson, Kari4 aut
710	2	a Karolinska Institutetb Institutionen för kliniska vetenskaper, Avdelningen för onkologi4 org
773	0	t Nature geneticsd : Springer Science and Business Media LLCg 42:5, s. 415-9q 42:5<415-9x 1546-1718x 1061-4036
856	4	u https://europepmc.org/articles/pmc2923020?pdf=render
856	4 8	u https://gup.ub.gu.se/publication/134597
856	4 8	u https://doi.org/10.1038/ng.558
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:120375072

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Av författaren/redakt...: Kiemeney, Lamber ...; Sulem, Patrick; Besenbacher, Sor ...; Vermeulen, Sita ...; Sigurdsson, Asge ...; Thorleifsson, Gu ...; visa fler...; Gudbjartsson, Da ...; Stacey, Simon N; Gudmundsson, Jul ...; Zanon, Carlo; Kostic, Jelena; Masson, Gisli; Bjarnason, Hjord ...; Palsson, Stefan ...; Skarphedinsson, ...; Gudjonsson, Sigu ...; Witjes, J Alfred; Grotenhuis, Anne ...; Verhaegh, Gerald ...; Bishop, D Timoth ...; Sak, Sei Chung; Choudhury, Anany ...; Elliott, Faye; Barrett, Jennife ...; Hurst, Carolyn D; de Verdier, Petr ...; Ryk, Charlotta; Rudnai, Peter; Gurzau, Eugene; Koppova, Kvetosl ...; Vineis, Paolo; Polidoro, Silvia; Guarrera, Simone ...; Sacerdote, Carlo ...; Campagna, Marcel ...; Placidi, Donatel ...; Arici, Cecilia; Zeegers, Maurice ...; Kellen, Eliane; Gutierrez, Berta ...; Sanz-Velez, José ...; Sanchez-Zalabard ...; Valdivia, Gabrie ...; Garcia-Prats, Ma ...; Hengstler, Jan G; Blaszkewicz, Mei ...; Dietrich, Holger; Ophoff, Roel A; van den Berg, Le ...; Alexiusdottir, K ...; Kristjansson, Kr ...; Geirsson, Gudmun ...; Nikulasson, Sigf ...; Petursdottir, Vi ...; Kong, Augustine; Thorgeirsson, Th ...; Mungan, N Aydin; Lindblom, Annika; van Es, Michael ...; Porru, Stefano; Buntinx, Frank; Golka, Klaus; Mayordomo, José ...; Kumar, Rajiv; Matullo, Giusepp ...; Steineck, Gunnar ...; Kiltie, Anne E; Aben, Katja K H; Jonsson, Eirikur; Thorsteinsdottir ...; Knowles, Margare ...; Rafnar, Thorunn; Stefansson, Kari; visa färre...

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Av lärosätet: Göteborgs universitet; Karolinska Institutet

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