WFRF:(Engstrand P.)
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The protective role of commensal gut microbes and their metabolites against bacterial pathogens
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- Cheng, Liqin (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.;Cent South Univ, Changsha, Peoples R China.
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- Correia, Mario S. P. (author)
- Uppsala universitet,Institutionen för kemi - BMC,Science for Life Laboratory, SciLifeLab
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- Higdon, Shawn M. (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden;Cent South Univ, Changsha, Peoples R China. Institutionen för kemi - BMC (creator_code:org_t)
- Taylor & Francis, 2024
- 2024
- English.
- In: Gut microbes. - : Taylor & Francis. - 1949-0976 .- 1949-0984. ; 16:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Multidrug-resistant microorganisms have become a major public health concern around the world. The gut microbiome is a gold mine for bioactive compounds that protect the human body from pathogens. We used a multi-omics approach that integrated whole-genome sequencing (WGS) of 74 commensal gut microbiome isolates with metabolome analysis to discover their metabolic interaction with Salmonella and other antibiotic-resistant pathogens. We evaluated differences in the functional potential of these selected isolates based on WGS annotation profiles. Furthermore, the top altered metabolites in co-culture supernatants of selected commensal gut microbiome isolates were identified including a series of dipeptides and examined for their ability to prevent the growth of various antibiotic-resistant bacteria. Our results provide compelling evidence that the gut microbiome produces metabolites, including the compound class of dipeptides that can potentially be applied for anti-infection medication, especially against antibiotic-resistant pathogens. Our established pipeline for the discovery and validation of bioactive metabolites from the gut microbiome as novel candidates for multidrug-resistant infections represents a new avenue for the discovery of antimicrobial lead structures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Commensal bacteria
- Salmonella
- metabolite
- adenosine
- adenine
- antibiotic-resistant
- dipeptides
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Cheng, Liqin
- Correia, Mario S ...
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- Tsiara, Ioanna
- Joffre, Enrique
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- Sjoling, Asa
- Boulund, Fredrik
- Norin, Elisabeth ...
- Engstrand, Lars
- Globisch, Daniel
- Du, Juan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- and Basic Medicine
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- Gut microbes
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- Uppsala University
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