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WFRF:(Fey Martin F.)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002950naa a2200409 4500
001oai:gup.ub.gu.se/99958
003SwePub
008240528s2009 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/999582 URI
0247 a https://doi.org/10.1007/s10549-008-0282-02 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pagani, Olivia4 aut
2451 0a Patterns of recurrence of early breast cancer according to estrogen receptor status: a therapeutic target for a quarter of a century.
264 c 2009-01-10
264 1b Springer Science and Business Media LLC,c 2009
520 a The current therapeutic strategy in breast cancer is to identify a target, such as estrogen receptor (ER) status, for tailoring treatments. We investigated the patterns of recurrence with respect to ER status for patients treated in two randomized trials with 25 years' median follow-up. In the ER-negative subpopulations most breast cancer events occurred within the first 5-7 years after randomization, while in the ER-positive subpopulations breast cancer events were spread through 10 years. In the ER-positive subpopulation, 1 year endocrine treatment alone significantly prolonged disease-free survival (DFS) with no additional benefit observed by adding 1 year of chemotherapy. In the small ER-negative subpopulation chemo-endocrine therapy had a significantly better DFS than endocrine alone or no treatment. Despite small numbers of patients, "old-fashioned" treatments, and competing causes of treatment failure, the value of ER status as a target for response to adjuvant treatment is evident through prolonged follow-up.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Price, Karen N4 aut
7001 a Gelber, Richard D4 aut
7001 a Castiglione-Gertsch, Monica4 aut
7001 a Holmberg, Stig B,d 1946u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery4 aut
7001 a Lindtner, Jurij4 aut
7001 a Thürlimann, Beat4 aut
7001 a Collins, John4 aut
7001 a Fey, Martin F4 aut
7001 a Coates, Alan S4 aut
7001 a Goldhirsch, Aron4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för kirurgi4 org
7730 t Breast cancer research and treatmentd : Springer Science and Business Media LLCg 117:2, s. 319-24q 117:2<319-24x 1573-7217x 0167-6806
8564 u https://europepmc.org/articles/pmc3589101?pdf=render
8564 8u https://gup.ub.gu.se/publication/99958
8564 8u https://doi.org/10.1007/s10549-008-0282-0

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