SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Forgetta Vincenzo)
 

Sökning: WFRF:(Forgetta Vincenzo) > Proteome-wide Mende...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008181naa a2200685 4500
001oai:DiVA.org:uu-502163
003SwePub
008230522s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:152002535
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5021632 URI
0247 a https://doi.org/10.1038/s42255-023-00742-w2 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1520025352 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Yoshiji, Satoshiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.4 aut
2451 0a Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
264 c 2023-02-20
264 1b Springer Nature,c 2023
338 a print2 rdacarrier
520 a How obesity contributes to COVID-19 severity is not fully understood. In this study, Yoshiji et al. found that the plasma protein nephronectin partially mediates the effect of obesity on the risk of COVID-19 severity using a two-step Mendelian randomization approach and omics analyses. Obesity is a major risk factor for Coronavirus disease (COVID-19) severity; however, the mechanisms underlying this relationship are not fully understood. As obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index using Mendelian randomization. This yielded 1,216 proteins, whose effect on COVID-19 severity was assessed, again using Mendelian randomization. We found that an s.d. increase in nephronectin (NPNT) was associated with increased odds of critically ill COVID-19 (OR = 1.71, P = 1.63 x 10(-10)). The effect was driven by an NPNT splice isoform. Mediation analyses supported NPNT as a mediator. In single-cell RNA-sequencing, NPNT was expressed in alveolar cells and fibroblasts of the lung in individuals who died of COVID-19. Finally, decreasing body fat mass and increasing fat-free mass were found to lower NPNT levels. These findings provide actionable insights into how obesity influences COVID-19 severity.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Butler-Laporte, Guillaumeu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.4 aut
7001 a Lu, Tianyuanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Quantitat Life Sci Program, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.4 aut
7001 a Willett, Julian Daniel Sundayu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Quantitat Life Sci Program, Montreal, PQ, Canada.4 aut
7001 a Su, Chen-Yangu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Comp Sci, Montreal, PQ, Canada.4 aut
7001 a Nakanishi, Tomokou McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.4 aut
7001 a Morrison, David R.u McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Chen, Yihengu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.4 aut
7001 a Liang, Kevinu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Quantitat Life Sci Program, Montreal, PQ, Canada.4 aut
7001 a Hultström, Michael,d 1978-u Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård,McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.4 aut0 (Swepub:uu)mihul498
7001 a Ilboudo, Yannu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Afrasiabi, Zamanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Lan, Shanshanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Duggan, Naomiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a DeLuca, Chantalu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Vaezi, Mitrau McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Tselios, Chrisu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Xue, Xiaoqingu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Bouab, Meriemu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Shi, Fangyiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Laurent, Laetitiau McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Münter, Hans Markusu McGill Univ, McGill Genome Ctr, Montreal, PQ, Canada.4 aut
7001 a Afilalo, Marcu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Dept Emergency Med, Montreal, PQ, Canada.4 aut
7001 a Afilalo, Jonathanu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;McGill Univ, Jewish Gen Hosp, Div Cardiol, Montreal, PQ, Canada.4 aut
7001 a Mooser, Vincentu McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, McGill Genome Ctr, Montreal, PQ, Canada.4 aut
7001 a Timpson, Nicholas J.u Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.4 aut
7001 a Zeberg, Hugou Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Max Planck Inst Evolutionary Anthropol, Leipzig, Germany.4 aut
7001 a Zhou, Siruiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, McGill Genome Ctr, Montreal, PQ, Canada.4 aut
7001 a Forgetta, Vincenzou McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.4 aut
7001 a Farjoun, Yossiu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.4 aut
7001 a Richards, J. Brentu McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.;5 Prime Sci, Montreal, PQ, Canada.;Kings Coll London, Dept Twin Res, London, England.4 aut
7102 a McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;Kyoto Univ, Grad Sch Med, Kyoto McGill Int Collaborat Program Genom Med, Kyoto, Japan.;Japan Soc Promot Sci, Tokyo, Japan.b McGill Univ, Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.4 org
7730 t Nature Metabolismd : Springer Natureg 5, s. 248-264q 5<248-264x 2522-5812
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502163
8564 8u https://doi.org/10.1038/s42255-023-00742-w
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:152002535

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy