A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021

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Fältnamn	Indikatorer	Metadata
000		10054nam a2201849 4500
001		oai:DiVA.org:uu-478263
003		SwePub
008		220622s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4782632 URI
024	7	a https://doi.org/10.1101/2022.05.26.222755322 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a ovr2 swepub-publicationtype
100	1	a Wulf Hanson, Sarah4 aut
245	1 0	a A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021
264	1	b Cold Spring Harbor Laboratory,c 2022
338		a print2 rdacarrier
520		a Importance: While much of the attention on the COVID-19 pandemic was directed at the daily counts of cases and those with serious disease overwhelming health services, increasingly, reports have appeared of people who experience debilitating symptoms after the initial infection. This is popularly known as long COVID.Objective: To estimate by country and territory of the number of patients affected by long COVID in 2020 and 2021, the severity of their symptoms and expected pattern of recovery.Design: We jointly analyzed ten ongoing cohort studies in ten countries for the occurrence of three major symptom clusters of long COVID among representative COVID cases. The defining symptoms of the three clusters (fatigue, cognitive problems, and shortness of breath) are explicitly mentioned in the WHO clinical case definition. For incidence of long COVID, we adopted the minimum duration after infection of three months from the WHO case definition. We pooled data from the contributing studies, two large medical record databases in the United States, and findings from 44 published studies using a Bayesian meta-regression tool. We separately estimated occurrence and pattern of recovery in patients with milder acute infections and those hospitalized. We estimated the incidence and prevalence of long COVID globally and by country in 2020 and 2021 as well as the severity-weighted prevalence using disability weights from the Global Burden of Disease study.Results: Analyses are based on detailed information for 1906 community infections and 10526 hospitalized patients from the ten collaborating cohorts, three of which included children. We added published data on 37262 community infections and 9540 hospitalized patients as well as ICD-coded medical record data concerning 1.3 million infections. Globally, in 2020 and 2021, 144.7 million (95% uncertainty interval [UI] 54.8-312.9) people suffered from any of the three symptom clusters of long COVID. This corresponds to 3.69% (1.38-7.96) of all infections. The fatigue, respiratory, and cognitive clusters occurred in 51.0% (16.9-92.4), 60.4% (18.9-89.1), and 35.4% (9.4-75.1) of long COVID cases, respectively. Those with milder acute COVID-19 cases had a quicker estimated recovery (median duration 3.99 months [IQR 3.84-4.20]) than those admitted for the acute infection (median duration 8.84 months [IQR 8.10-9.78]). At twelve months, 15.1% (10.3-21.1) continued to experience long COVID symptoms.Conclusions and relevance: The occurrence of debilitating ongoing symptoms of COVID-19 is common. Knowing how many people are affected, and for how long, is important to plan for rehabilitative services and support to return to social activities, places of learning, and the workplace when symptoms start to wane.Key Points: Question: What are the extent and nature of the most common long COVID symptoms by country in 2020 and 2021?Findings: Globally, 144.7 million people experienced one or more of three symptom clusters (fatigue; cognitive problems; and ongoing respiratory problems) of long COVID three months after infection, in 2020 and 2021. Most cases arose from milder infections. At 12 months after infection, 15.1% of these cases had not yet recovered.Meaning: The substantial number of people with long COVID are in need of rehabilitative care and support to transition back into the workplace or education when symptoms start to wane.
653		a Lungmedicin
653		a Lung Medicine
653		a Clinical Physiology
653		a Klinisk fysiologi
653		a Fysiologi
653		a Physiology
700	1	a Abbafati, Cristiana4 aut
700	1	a Aerts, Joachim G4 aut
700	1	a Al-Aly, Ziyad4 aut
700	1	a Ashbaugh, Charlie4 aut
700	1	a Ballouz, Tala4 aut
700	1	a Blyuss, Oleg4 aut
700	1	a Bobkova, Polina4 aut
700	1	a Bonsel, Gouke4 aut
700	1	a Borzakova, Svetlana4 aut
700	1	a Buonsenso, Danilo4 aut
700	1	a Butnaru, Denis4 aut
700	1	a Carter, Austin4 aut
700	1	a Chu, Helen4 aut
700	1	a De Rose, Cristina4 aut
700	1	a Diab, Mohamed Mustafa4 aut
700	1	a Ekbom, Emil4 aut
700	1	a El Tantawi, Maha4 aut
700	1	a Fomin, Victor4 aut
700	1	a Frithiof, Robertu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)robfr118
700	1	a Gamirova, Aysylu4 aut
700	1	a Glybochko, Petr V4 aut
700	1	a Haagsma, Juanita A4 aut
700	1	a Javanmard, Shaghayegh Haghjooy4 aut
700	1	a Hamilton, Erin B4 aut
700	1	a Harris, Gabrielle4 aut
700	1	a Heijenbrok-Kal, Majanka H4 aut
700	1	a Helbok, Raimund4 aut
700	1	a Hellemons, Merel E4 aut
700	1	a Hillus, David4 aut
700	1	a Huijts, Susanne M4 aut
700	1	a Hultström, Michaelu Uppsala universitet,Anestesiologi och intensivvård,Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.4 aut0 (Swepub:uu)mihul498
700	1	a Jassat, Waasila4 aut
700	1	a Kurth, Florian4 aut
700	1	a Larsson, Ing-Marieu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)ingla697
700	1	a Lipcsey, Miklósu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)milip123
700	1	a Liu, Chelsea4 aut
700	1	a Loflin, Callan D4 aut
700	1	a Malinovschi, Andrei,d 1978-u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)anmal535
700	1	a Mao, Wenhui4 aut
700	1	a Mazankova, Lyudmila4 aut
700	1	a McCulloch, Denise4 aut
700	1	a Menges, Dominik4 aut
700	1	a Mohammadifard, Noushin4 aut
700	1	a Munblit, Daniel4 aut
700	1	a Nekliudov, Nikita A4 aut
700	1	a Ogbuoji, Osondu4 aut
700	1	a Osmanov, Ismail M4 aut
700	1	a Peñalvo, José L4 aut
700	1	a Petersen, Maria Skaalum4 aut
700	1	a Puhan, Milo A4 aut
700	1	a Rahman, Mujibur4 aut
700	1	a Rass, Verena4 aut
700	1	a Reinig, Nickolas4 aut
700	1	a Ribbers, Gerard M4 aut
700	1	a Ricchiuto, Antonia4 aut
700	1	a Rubertsson, Stenu Uppsala universitet,Hedenstiernalaboratoriet4 aut0 (Swepub:uu)stenrube
700	1	a Samitova, Elmira4 aut
700	1	a Sarrafzadegan, Nizal4 aut
700	1	a Shikhaleva, Anastasia4 aut
700	1	a Simpson, Kyle E4 aut
700	1	a Sinatti, Dario4 aut
700	1	a Soriano, Joan B4 aut
700	1	a Spiridonova, Ekaterina4 aut
700	1	a Steinbeis, Fridolin4 aut
700	1	a Svistunov, Andrey A4 aut
700	1	a Valentini, Piero4 aut
700	1	a van de Water, Brittney J4 aut
700	1	a van den Berg-Emons, Rita4 aut
700	1	a Wallin, Ewau Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)ewawa635
700	1	a Witzenrath, Martin4 aut
700	1	a Wu, Yifan4 aut
700	1	a Xu, Hanzhang4 aut
700	1	a Zoller, Thomas4 aut
700	1	a Adolph, Christopher4 aut
700	1	a Albright, James4 aut
700	1	a Amlag, Joanne O4 aut
700	1	a Aravkin, Aleksandr Y4 aut
700	1	a Bang-Jensen, Bree L4 aut
700	1	a Bisignano, Catherine4 aut
700	1	a Castellano, Rachel4 aut
700	1	a Castro, Emma4 aut
700	1	a Chakrabarti, Suman4 aut
700	1	a Collins, James K4 aut
700	1	a Dai, Xiaochen4 aut
700	1	a Daoud, Farah4 aut
700	1	a Dapper, Carolyn4 aut
700	1	a Deen, Amanda4 aut
700	1	a Duncan, Bruce B4 aut
700	1	a Erickson, Megan4 aut
700	1	a Ewald, Samuel B4 aut
700	1	a Ferrari, Alize J4 aut
700	1	a Flaxman, Abraham D4 aut
700	1	a Fullman, Nancy4 aut
700	1	a Gamkrelidze, Amiran4 aut
700	1	a Giles, John R4 aut
700	1	a Guo, Gaorui4 aut
700	1	a Hay, Simon I4 aut
700	1	a He, Jiawei4 aut
700	1	a Helak, Monika4 aut
700	1	a Hulland, Erin N4 aut
700	1	a Kereselidze, Maia4 aut
700	1	a Krohn, Kris J4 aut
700	1	a Lazzar-Atwood, Alice4 aut
700	1	a Lindstrom, Akiaja4 aut
700	1	a Lozano, Rafael4 aut
700	1	a Magistro, Beatrice4 aut
700	1	a Malta, Deborah Carvalho4 aut
700	1	a Månsson, Johan4 aut
700	1	a Mantilla Herrera, Ana M4 aut
700	1	a Mokdad, Ali H4 aut
700	1	a Monasta, Lorenzo4 aut
700	1	a Nomura, Shuhei4 aut
700	1	a Pasovic, Maja4 aut
700	1	a Pigott, David M4 aut
700	1	a Reiner, Robert C4 aut
700	1	a Reinke, Grace4 aut
700	1	a Ribeiro, Antonio Luiz P4 aut
700	1	a Santomauro, Damian Francesco4 aut
700	1	a Sholokhov, Aleksei4 aut
700	1	a Spurlock, Emma Elizabeth4 aut
700	1	a Walcott, Rebecca4 aut
700	1	a Walker, Ally4 aut
700	1	a Wiysonge, Charles Shey4 aut
700	1	a Zheng, Peng4 aut
700	1	a Bettger, Janet Prvu4 aut
700	1	a Murray, Christopher Jl4 aut
700	1	a Vos, Theo4 aut
710	2	a Uppsala universitetb Anestesiologi och intensivvård4 org
856	4	u https://www.medrxiv.org/content/10.1101/2022.05.26.22275532v1
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478263
856	4 8	u https://doi.org/10.1101/2022.05.26.22275532

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Av författaren/redakt...: Wulf Hanson, Sar ...; Abbafati, Cristi ...; Aerts, Joachim G; Al-Aly, Ziyad; Ashbaugh, Charli ...; Ballouz, Tala; visa fler...; Blyuss, Oleg; Bobkova, Polina; Bonsel, Gouke; Borzakova, Svetl ...; Buonsenso, Danil ...; Butnaru, Denis; Carter, Austin; Chu, Helen; De Rose, Cristin ...; Diab, Mohamed Mu ...; Ekbom, Emil; El Tantawi, Maha; Fomin, Victor; Frithiof, Robert; Gamirova, Aysylu; Glybochko, Petr ...; Haagsma, Juanita ...; Javanmard, Shagh ...; Hamilton, Erin B; Harris, Gabriell ...; Heijenbrok-Kal, ...; Helbok, Raimund; Hellemons, Merel ...; Hillus, David; Huijts, Susanne ...; Hultström, Micha ...; Jassat, Waasila; Kurth, Florian; Larsson, Ing-Mar ...; Lipcsey, Miklós; Liu, Chelsea; Loflin, Callan D; Malinovschi, And ...; Mao, Wenhui; Mazankova, Lyudm ...; McCulloch, Denis ...; Menges, Dominik; Mohammadifard, N ...; Munblit, Daniel; Nekliudov, Nikit ...; Ogbuoji, Osondu; Osmanov, Ismail ...; Peñalvo, José L; Petersen, Maria ...; Puhan, Milo A; Rahman, Mujibur; Rass, Verena; Reinig, Nickolas; Ribbers, Gerard ...; Ricchiuto, Anton ...; Rubertsson, Sten; Samitova, Elmira; Sarrafzadegan, N ...; Shikhaleva, Anas ...; Simpson, Kyle E; Sinatti, Dario; Soriano, Joan B; Spiridonova, Eka ...; Steinbeis, Frido ...; Svistunov, Andre ...; Valentini, Piero; van de Water, Br ...; van den Berg-Emo ...; Wallin, Ewa; Witzenrath, Mart ...; Wu, Yifan; Xu, Hanzhang; Zoller, Thomas; Adolph, Christop ...; Albright, James; Amlag, Joanne O; Aravkin, Aleksan ...; Bang-Jensen, Bre ...; Bisignano, Cathe ...; Castellano, Rach ...; Castro, Emma; Chakrabarti, Sum ...; Collins, James K; Dai, Xiaochen; Daoud, Farah; Dapper, Carolyn; Deen, Amanda; Duncan, Bruce B; Erickson, Megan; Ewald, Samuel B; Ferrari, Alize J; Flaxman, Abraham ...; Fullman, Nancy; Gamkrelidze, Ami ...; Giles, John R; Guo, Gaorui; Hay, Simon I; He, Jiawei; Helak, Monika; Hulland, Erin N; Kereselidze, Mai ...; Krohn, Kris J; Lazzar-Atwood, A ...; Lindstrom, Akiaj ...; Lozano, Rafael; Magistro, Beatri ...; Malta, Deborah C ...; Månsson, Johan; Mantilla Herrera ...; Mokdad, Ali H; Monasta, Lorenzo; Nomura, Shuhei; Pasovic, Maja; Pigott, David M; Reiner, Robert C; Reinke, Grace; Ribeiro, Antonio ...; Santomauro, Dami ...; Sholokhov, Aleks ...; Spurlock, Emma E ...; Walcott, Rebecca; Walker, Ally; Wiysonge, Charle ...; Zheng, Peng; Bettger, Janet P ...; Murray, Christop ...; Vos, Theo; visa färre...

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