Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns

INTRODUCTION: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups. METHODS: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory. RESULTS: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10−10). For overlap between imaging-defined and cognitively defined subgroups, AD-Memory matched up with an imaging-defined limbic predominant group. DISCUSSION: MRI findings differ across cognitively defined AD subgroups.

Groot, ColinLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam(Swepub:lu)co1654gr (författare)
Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam(Swepub:lu)ri1513os (författare)
Mukherjee, ShubhabrataWashington University School of Medicine (författare)
Choi, Seo EunWashington University School of Medicine (författare)
Lee, MichaelWashington University School of Medicine (författare)
Scollard, PhoebeWashington University School of Medicine (författare)
Gibbons, Laura E.Washington University School of Medicine (författare)
Sanders, R. ElizabethWashington University School of Medicine (författare)
Trittschuh, EmilyUniversity of Washington (författare)
Saykin, Andrew J.Indiana University (författare)
Mez, JesseBoston University (författare)
Nakano, ConnieWashington University School of Medicine (författare)
Donald, Christine MacUniversity of Washington (författare)
Sohi, HarkiratUniversity of Washington,Pacific Northwest National Laboratory (författare)
Risacher, ShannonIndiana University (författare)
Washington University School of MedicineKlinisk minnesforskning (creator_code:org_t)

Av författaren/redakt...: Crane, Paul K.; Groot, Colin; Ossenkoppele, Ri ...; Mukherjee, Shubh ...; Choi, Seo Eun; Lee, Michael; visa fler...; Scollard, Phoebe; Gibbons, Laura E ...; Sanders, R. Eliz ...; Trittschuh, Emil ...; Saykin, Andrew J ...; Mez, Jesse; Nakano, Connie; Donald, Christin ...; Sohi, Harkirat; Risacher, Shanno ...; visa färre...

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