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WFRF:(Giugliano Robert P.)
 

Sökning: WFRF:(Giugliano Robert P.) > Obesity, Diabetes, ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004818naa a2200505 4500
001oai:DiVA.org:uu-336301
003SwePub
008180123s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3363012 URI
0247 a https://doi.org/10.1016/j.amjmed.2017.03.0302 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Koshizaka, Masayau Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.;Chiba Univ Hosp, Clin Res Ctr, Div Diabet Metab & Endocrinol, Chiba, Japan.4 aut
2451 0a Obesity, Diabetes, and Acute Coronary Syndrome :b Differences Between Asians and Whites
264 1b Elsevier BV,c 2017
338 a print2 rdacarrier
520 a BACKGROUND:Most diabetes and cardiovascular studies have been conducted in white patients, with data being extrapolated to other population groups.METHODS:For this analysis, patient-level data were extracted from 5 randomized clinical trials in patients with acute coronary syndrome; we compared obesity levels between Asian and white populations, stratified by diabetes status. By using an adjusted Cox proportional hazards model, hazard ratios (HRs) for cardiovascular outcomes after an acute coronary syndrome were determined.RESULTS:We identified 49,224 patient records from the 5 trials, with 3176 Asians and 46,048 whites. Whites with diabetes had higher body mass index values than those without diabetes (median 29.3 vs 27.2 kg/m(2); P <.0001), whereas Asians with diabetes and without diabetes had similar body mass index (24.7 vs 24.2 kg/m2). Asians with diabetes (HR, 1.63; 95% confidence interval [CI], 1.32-2.02), whites with diabetes (HR, 1.15; 95% CI, 1.06-1.25), and Asians without diabetes (HR, 1.36; 95% CI, 1.14-1.64) had higher rates of the composite of death, myocardial infarction, or stroke at 30 days than whites without diabetes. Asians with diabetes (HR, 1.84; 95% CI, 1.47-2.31), whites with diabetes (HR, 1.47; 95% CI, 1.33-1.62), and Asians without diabetes (HR, 1.38; 95% CI, 1.11-1.73) had higher rates of death at 1 year compared with whites without diabetes. There were no significant interactions between race and diabetes for ischemic outcomes.CONCLUSIONS:Although Asians with diabetes and acute coronary syndrome are less likely to be obese than their white counterparts, their risk for death or recurrent ischemic events was not lower.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Acute coronary syndrome
653 a Diabetes
653 a Ischemic outcomes
653 a Obesity
653 a Race
7001 a Lopes, Renato D.u Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.4 aut
7001 a Newby, L. Kristinu Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.4 aut
7001 a Clare, Robert M.u Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.4 aut
7001 a Schulte, Phillip J.u Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.4 aut
7001 a Tricoci, Pierluigiu Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.4 aut
7001 a Mahaffey, Kenneth W.u Stanford Univ, Dept Med, Stanford, CA 94305 USA.4 aut
7001 a Ogawa, Hisaou Natl Cerebral & Cardiovasc Ctr, Osaka, Japan.4 aut
7001 a Moliterno, David J.u Univ Kentucky, Gill Heart Inst, Lexington, KY 40506 USA.;Univ Kentucky, Div Cardiovasc Med, Lexington, KY 40506 USA.4 aut
7001 a Giugliano, Robert P.u Brigham & Womens Hosp, TIMI Study Grp, Div Cardiovasc Med, 75 Francis St, Boston, MA 02115 USA.4 aut
7001 a Huber, Kurtu Wilhelminen Hosp, Cardiol & Intens Care Med, Med Dept 3, Vienna, Austria.;Sigmund Freud Private Univ, Med Sch, Vienna, Austria.4 aut
7001 a James, Stefan,d 1964-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)stjam367
7001 a Harrington, Robert A.u Stanford Univ, Dept Med, Stanford, CA 94305 USA.4 aut
7001 a Alexander, John H.u Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.4 aut
7102 a Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.;Chiba Univ Hosp, Clin Res Ctr, Div Diabet Metab & Endocrinol, Chiba, Japan.b Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA.4 org
7730 t American Journal of Medicined : Elsevier BVg 130:10, s. 1170-1176q 130:10<1170-1176x 0002-9343x 1555-7162
8564 u http://www.amjmed.com/article/S0002934317303571/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336301
8564 8u https://doi.org/10.1016/j.amjmed.2017.03.030

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