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High IgA anti-phosp...
High IgA anti-phospholipid autoantibodies in healthy Sudanese explains the increased prevalence among Sudanese compared to Swedish systemic lupus erythematosus patients
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- Elbagir, Sahwa (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Johan Rönnelid
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- ElShafie, Amir Ibrahim, 1970- (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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Elagib, Elnour. M. (författare)
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Mohammed, NasrEldeen. A. (författare)
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Aledrissy, Mawahib. I. E. (författare)
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- Manivel, Vivek Anand (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Pertsinidou, Eleftheria (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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Nur, Musa. A. M. (författare)
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- Gunnarsson, Iva (författare)
- Karolinska Institutet
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- Svenungsson, Elisabet (författare)
- Karolinska Institutet
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- Rönnelid, Johan (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
- 2020-08-02
- 2020
- Engelska.
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Ingår i: Lupus. - : Sage Publications. - 0961-2033 .- 1477-0962. ; 29:11, s. 1412-1422
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://journals.sag...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives: IgA antiphospholipid antibodies (aPL) are prevalent in systemic lupus erythematosus (SLE) patients of African American, Afro-Caribbean and South African origin. Nevertheless, data from North Africa are lacking, and most studies use manufacturer-suggested cut-offs based on Caucasian controls. Therefore, we compared aPL isotypes in Sudanese and Swedish SLE patients using nation-based cut-offs.Methods: Consecutive SLE patients and age- and sex-matched controls from Sudan (N = 115/106) and Sweden (N = 340/318) were included. All patients fulfilled the 1982 American College of Rheumatology SLE classification criteria. Antiphospholipid syndrome-related events were obtained from patients' records. IgA/G/M anticardiolipin and anti-β2 glycoprotein I (β2GPI) were analysed with two independent assays. IgA anti-β2GPI domain 1 (D1) was also investigated. Manufacturers' cut-offs and the 95th and 99th percentile cut-offs based on national controls were used.Results: Sudanese patients and controls had higher levels and were more often positive for IgA aPL than Swedes when using manufacturers' cut-offs. In contrast, using national cut-offs, the increase in IgA aPL among Sudanese patients was lost. Occurrence of IgA anti-D1 did not differ between the countries. Venous thromboses were less common among Sudanese patients and did not associate with aPL. No clinical associations were observed with IgA anti-β2GPI in Sudanese patients. Thromboses in Swedes were associated with IgG/M aPL. Fetal loss was associated with aPL in both cohorts.Conclusions: IgA anti-β2GPI prevalence was higher among Sudanese compared to Swedish patients when manufacturers' cut-offs were used. This situation was reversed when applying national cut-offs. Anti-D1 was not increased in Sudanese patients. Previous studies on populations of African origin, which demonstrate a high prevalence of IgA aPL positivity, should be re-evaluated using a similar cut-off approach.
Nyckelord
- Africa
- IgA; Sudan
- Sweden
- Systemic lupus erythematosus
- anti-β2-glycoprotein I
- antiphospholipid antibodies.
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- art (ämneskategori)
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Elbagir, Sahwa
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ElShafie, Amir I ...
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Elagib, Elnour. ...
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Mohammed, NasrEl ...
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Aledrissy, Mawah ...
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Manivel, Vivek A ...
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Pertsinidou, Ele ...
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Nur, Musa. A. M.
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Gunnarsson, Iva
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Svenungsson, Eli ...
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Rönnelid, Johan
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Uppsala universitet
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Karolinska Institutet