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Sökning: WFRF:(Gupta Ramneek) > (2015-2019) > Cerebellar mutism s...

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FältnamnIndikatorerMetadata
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009oai:lup.lub.lu.se:3b94fe51-5ede-44c7-b145-50a32f25b51b
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0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3296542 URI
0247 a https://doi.org/10.1186/s12885-017-3416-02 DOI
0247 a https://lup.lub.lu.se/record/3b94fe51-5ede-44c7-b145-50a32f25b51b2 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360561372 URI
040 a (SwePub)uud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wibroe, Mortenu Rigshosp, Dept Neurosurg, Copenhagen, Denmark.;Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital4 aut
2451 0a Cerebellar mutism syndrome in children with brain tumours of the posterior fossa
264 c 2017-06-21
264 1b BIOMED CENTRAL LTD,c 2017
338 a electronic2 rdacarrier
520 a Background: Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of posterior fossa tumour surgery is the cerebellar mutism syndrome (CMS) which has been reported in up to 39% of the patients but the exact incidence is uncertain since milder cases may be unrecognized. Recovery is usually incomplete. Reported risk factors are tumour type, midline location and brainstem involvement, but the exact aetiology, surgical and other risk factors, the clinical course and strategies for prevention and treatment are yet to be determined.Methods: This observational, prospective, multicentre study will include 500 children with posterior fossa tumours. It opened late 2014 with participation from 20 Nordic and Baltic centres. From 2016, five British centres and four Dutch centres will join with a total annual accrual of 130 patients. Three other major European centres are invited to join from 2016/17. Follow-up will run for 12 months after inclusion of the last patient. All patients are treated according to local practice. Clinical data are collected through standardized online registration at pre-determined time points pre- and postoperatively. Neurological status and speech functions are examined pre- operatively and postoperatively at 1-4 weeks, 2 and 12 months. Pre- and postoperative speech samples are recorded and analysed. Imaging will be reviewed centrally. Pathology is classified according to the 2007 WHO system. Germline DNA will be collected from all patients for associations between CMS characteristics and host genome variants including pathway profiles.Discussion: Through prospective and detailed collection of information on 1) differences in incidence and clinical course of CMS for different patient and tumour characteristics, 2) standardized surgical data and their association with CMS, 3) diversities and results of other therapeutic interventions, and 4) the role of host genome variants, we aim to achieve a better understanding of risk factors for and the clinical course of CMS - with the ultimate goal of defining strategies for prevention and treatment of this severely disabling condition.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Cancer
653 a Paediatric
653 a Children
653 a Cerebellar mutism
653 a CMS
653 a Brain tumour
653 a Cerebellum
653 a Posterior fossa syndrome
653 a Genetics
653 a Neurosurgery
653 a Brain tumour
653 a Cancer
653 a Cerebellar mutism
653 a Cerebellum
653 a Children
653 a CMS
653 a Genetics
653 a Neurosurgery
653 a Paediatric
653 a Posterior fossa syndrome
7001 a Cappelen, Johanu St Olavs Hosp, Dept Neurosurg, Trondheim, Norway.,St. Olav’s University Hospital4 aut
7001 a Castor, Charlotteu Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-ccs
7001 a Clausen, Nielsu Aarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.,Aarhus University Hospital4 aut
7001 a Grillner, Pernillau Karolinska Institutet4 aut
7001 a Gudrunardottir, Thorau Posterior Fossa Soc Https Www Posteriorfossa Org, Stockholm, Sweden.;North Zealand Hosp, Dept Oncol & Palliat, Hillerod, Denmark.,Posterior Fossa Society,Nordsjællands Hospital4 aut
7001 a Gupta, Ramneeku Tech Univ Denmark, Ctr Biol Sequence Anal, Lyngby, Denmark.,Technical University of Denmark4 aut
7001 a Gustavsson, Bengtu Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Heyman, Matsu Karolinska Institutet4 aut
7001 a Holm, Stefanu Karolinska Univ Sjukhuset, Dept Womens & Childrens Hlth, Stockholm, Sweden.,Karolinska University Hospital4 aut
7001 a Karppinen, Atteu Helsinki Univ Hosp, Dept Neurosurg, Helsinki, Finland.,Helsinki University Central Hospital4 aut
7001 a Klausen, Camillau Rigshosp, Univ Hosp Copenhagen, Dept Neuroradiol, Copenhagen, Denmark.,Copenhagen University Hospital4 aut
7001 a Lönnqvist, Tuulau Univ Helsinki, Cent Hosp, Dept Child Neurol, Helsinki, Finland.,Helsinki University Central Hospital4 aut
7001 a Mathiasen, Reneu Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital4 aut
7001 a Nilsson, Pelleu Uppsala universitet,Neurokirurgi,Uppsala University Hospital4 aut0 (Swepub:uu)pellnils
7001 a Nysom, Karstenu Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital4 aut
7001 a Persson, Karinu Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine4 aut0 (Swepub:lu)med-kpr
7001 a Rask, Olofu Lund University,Lunds universitet,Enheten för pediatrisk hematologi,Forskargrupper vid Lunds universitet,Paediatric Hematologic Research Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-ora
7001 a Schmiegelow, Kjeldu Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.;Univ Langone, Med Ctr, Perlmutter Canc Ctr, Div Pediat Hematol Oncol, New York, NY USA.,Copenhagen University Hospital,University of Copenhagen4 aut
7001 a Sehested, Astridu Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital4 aut
7001 a Thomassen, Haraldu St Olavs Hosp, Dept Pediat, Trondheim, Norway.,St. Olav’s University Hospital4 aut
7001 a Tonning-Olsson, Ingridu Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk onkologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Oncology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-it0
7001 a Zetterqvist, Barbarau Karolinska Institute4 aut
7001 a Juhler, Marianneu Rigshosp, Dept Neurosurg, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.,University of Copenhagen,Copenhagen University Hospital4 aut
7102 a Rigshosp, Dept Neurosurg, Copenhagen, Denmark.;Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.b Copenhagen University Hospital4 org
7730 t BMC Cancerd : BIOMED CENTRAL LTDg 17q 17x 1471-2407
8564 u https://doi.org/10.1186/s12885-017-3416-0y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1142839/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-017-3416-0
8564 u http://dx.doi.org/10.1186/s12885-017-3416-0x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329654
8564 8u https://doi.org/10.1186/s12885-017-3416-0
8564 8u https://lup.lub.lu.se/record/3b94fe51-5ede-44c7-b145-50a32f25b51b
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:136056137

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