Sökning: WFRF:(Hakim A.) > Overdiagnosis of CO...
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000 | 19765naa a2202341 4500 | |
001 | oai:DiVA.org:uu-393117 | |
003 | SwePub | |
008 | 190924s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3931172 URI |
024 | 7 | a https://doi.org/10.1016/j.chest.2019.01.0152 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sator, Leau Paracelsus Med Univ, Dept Pulm Med, Salzburg, Austria4 aut |
245 | 1 0 | a Overdiagnosis of COPD in Subjects With Unobstructed Spirometry A BOLD Analysis |
264 | 1 | b Elsevier BV,c 2019 |
338 | a print2 rdacarrier | |
500 | a Group Author(s): BOLD Collaborative Res Grp | |
520 | a BACKGROUND: There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003 and 2012.METHODS: A false positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but postbronchodilator spirometry was unobstructed (FEV1/FVC > LLN). Additional analyses were performed using the fixed ratio criterion (FEV1/FVC < 0.7).RESULTS: Among 16,177 participants, 919 (5.7%) reported a previous medical diagnosis of COPD. Postbronchodilator spirometry was unobstructed in 569 subjects (61.9%): false positive COPD. A similar rate of overdiagnosis was seen when using the fixed ratio criterion (55.3%). In a subgroup analysis excluding participants who reported a diagnosis of "chronic bronchitis" or "emphysema" (n = 220), 37.7% had no airflow limitation. The site-specific prevalence of false positive COPD varied greatly, from 1.9% in low- to middle-income countries to 4.9% in high-income countries. In multivariate analysis, overdiagnosis was more common among women, and was associated with higher education; former and current smoking; the presence of wheeze, cough, and phlegm; and concomitant medical diagnosis of asthma or heart disease. Among the subjects with false positive COPD, 45.7% reported current use of respiratory medication. Excluding patients with reported asthma, 34.4% of those with normal spirometry still used a respiratory medication.CONCLUSIONS: False positive COPD is frequent. This might expose nonobstructed subjects to possible adverse effects of respiratory medication. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a COPD | |
653 | a false positive diagnosis | |
653 | a misdiagnosis | |
653 | a overdiagnosis | |
653 | a overtreatment | |
700 | 1 | a Horner, Andreasu Kepler Univ Hosp, Dept Pulmonol, Krankenhausstr 9, A-4021 Linz, Austria;Johannes Kepler Univ Linz, Fac Med, Linz, Austria;Paracelsus Med Univ, Inst Gen Practice Family Med & Prevent Med, Salzburg, Austria4 aut |
700 | 1 | a Studnicka, Michaelu Paracelsus Med Univ, Dept Pulm Med, Salzburg, Austria4 aut |
700 | 1 | a Lamprecht, Berndu Paracelsus Med Univ, Dept Pulm Med, Salzburg, Austria;Kepler Univ Hosp, Dept Pulmonol, Krankenhausstr 9, A-4021 Linz, Austria;Johannes Kepler Univ Linz, Fac Med, Linz, Austria4 aut |
700 | 1 | a Kaiser, Bernhardu Kepler Univ Hosp, Dept Pulmonol, Krankenhausstr 9, A-4021 Linz, Austria4 aut |
700 | 1 | a McBurnie, Mary Annu Kaiser Permanente Northwest, Ctr Hlth Res, Portland, OR USA4 aut |
700 | 1 | a Buist, A. Soniau Oregon Hlth & Sci Univ, Portland, OR 97201 USA4 aut |
700 | 1 | a Gnatiuc, Luisau Imperial Coll London, Resp Epidemiol & Publ Hlth Grp, London, England4 aut |
700 | 1 | a Mannino, David M.u Univ Kentucky, Dept Prevent Med & Environm Hlth, Coll Publ Hlth, Lexington, KY USA;Univ Kentucky, Lexington, KY USA4 aut |
700 | 1 | a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)chrisjn |
700 | 1 | a Bateman, Eric D.u Univ Cape Town, Div Pulmonol, Dept Med, Cape Town, South Africa4 aut |
700 | 1 | a Burney, Peteru Imperial Coll London, Resp Epidemiol & Publ Hlth Grp, London, England4 aut |
700 | 1 | a Zhong, NanShanu Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China4 aut |
700 | 1 | a Liu, Shengmingu Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China4 aut |
700 | 1 | a Lu, Jiachunu Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China4 aut |
700 | 1 | a Ran, Pixinu Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China4 aut |
700 | 1 | a Wang, Daliu Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China4 aut |
700 | 1 | a Zheng, Jingpingu Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China4 aut |
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700 | 1 | a Kocabas, Aliu Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkey4 aut |
700 | 1 | a Hancioglu, Attilau Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkey4 aut |
700 | 1 | a Hanta, Ismailu Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkey4 aut |
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700 | 1 | a Turkyilmaz, Ahmet Sinanu Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkey4 aut |
700 | 1 | a Umut, Semau Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkey4 aut |
700 | 1 | a Unalan, Turgayu Cukurova Univ, Dept Chest Dis, Sch Med, Adana, Turkey4 aut |
700 | 1 | a Dawes, Torkilu Paracelsus Med Univ, Dept Pulm Med, Salzburg, Austria4 aut |
700 | 1 | a Bateman, Ericu Univ Cape Town, Lung Inst, Cape Town, South Africa4 aut |
700 | 1 | a Jithoo, Anamikau Univ Cape Town, Lung Inst, Cape Town, South Africa4 aut |
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700 | 1 | a Gislason, Thorarinnu Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland4 aut |
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700 | 1 | a Gudmundsdottir, Lovisau Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland4 aut |
700 | 1 | a Gudmundsdottir, Sigrunu Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland4 aut |
700 | 1 | a Gundmundsson, Gunnaru Landspitali Univ Hosp, Dept Allergy Resp Med & Sleep, Reykjavik, Iceland4 aut |
700 | 1 | a Nizankowska-Mogilnicka, Ewau Jagiellonian Univ, Dept Med, Div Pulm Dis, Sch Med, Krakow, Poland4 aut |
700 | 1 | a Frey, Jakubu Jagiellonian Univ, Dept Med, Div Pulm Dis, Sch Med, Krakow, Poland4 aut |
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700 | 1 | a Nastalek, Pawelu Jagiellonian Univ, Dept Med, Div Pulm Dis, Sch Med, Krakow, Poland4 aut |
700 | 1 | a Pajak, Andrzeju Jagiellonian Univ, Dept Med, Div Pulm Dis, Sch Med, Krakow, Poland4 aut |
700 | 1 | a Skucha, Wojciechu Jagiellonian Univ, Dept Med, Div Pulm Dis, Sch Med, Krakow, Poland4 aut |
700 | 1 | a Szczeklik, Andrzeju Jagiellonian Univ, Dept Med, Div Pulm Dis, Sch Med, Krakow, Poland4 aut |
700 | 1 | a Twardowska, Magdau Jagiellonian Univ, Dept Med, Div Pulm Dis, Sch Med, Krakow, Poland4 aut |
700 | 1 | a Welte, Tobiasu Hannover Med Sch, Hannover, Germany4 aut |
700 | 1 | a Bodemann, Isabelleu Hannover Med Sch, Hannover, Germany4 aut |
700 | 1 | a Geldmacher, Henningu Hannover Med Sch, Hannover, Germany4 aut |
700 | 1 | a Schweda-Linow, Alexandrau Hannover Med Sch, Hannover, Germany4 aut |
700 | 1 | a Gulsvik, Amundu Univ Bergen, Inst Med, Dept Thorac Med, Bergen, Norway4 aut |
700 | 1 | a Endresen, Tinau Univ Bergen, Inst Med, Dept Thorac Med, Bergen, Norway4 aut |
700 | 1 | a Svendsen, Leneu Univ Bergen, Inst Med, Dept Thorac Med, Bergen, Norway4 aut |
700 | 1 | a Tan, Wan C.u Univ British Columbia, iCapture Ctr Cardiovasc & Pulm Res, Vancouver, BC, Canada4 aut |
700 | 1 | a Wang, Wenu Univ British Columbia, iCapture Ctr Cardiovasc & Pulm Res, Vancouver, BC, Canada4 aut |
700 | 1 | a Cain, Johnu Univ Kentucky, Lexington, KY USA4 aut |
700 | 1 | a Copeland, Rebeccau Univ Kentucky, Lexington, KY USA4 aut |
700 | 1 | a Hazen, Danau Univ Kentucky, Lexington, KY USA4 aut |
700 | 1 | a Methvin, Jenniferu Univ Kentucky, Lexington, KY USA4 aut |
700 | 1 | a Dantes, Renato B.u Philippine Coll Chest Phys, Manila, Philippines;Philippine Gen Hosp, Lung Ctr Philippines, Nampicuan, Philippines4 aut |
700 | 1 | a Amarillo, Lourdesu Philippine Coll Chest Phys, Manila, Philippines4 aut |
700 | 1 | a Berratio, Lakan U.u Philippine Coll Chest Phys, Manila, Philippines4 aut |
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700 | 1 | a Jenkins, Christineu Woolcock Inst Med Res, Sydney, NSW, Australia4 aut |
700 | 1 | a Marks, Guyu Woolcock Inst Med Res, Sydney, NSW, Australia4 aut |
700 | 1 | a Bird, Tessau Woolcock Inst Med Res, Sydney, NSW, Australia4 aut |
700 | 1 | a Espinel, Paolau Woolcock Inst Med Res, Sydney, NSW, Australia4 aut |
700 | 1 | a Hardaker, Kateu Woolcock Inst Med Res, Sydney, NSW, Australia4 aut |
700 | 1 | a Toelle, Brettu Woolcock Inst Med Res, Sydney, NSW, Australia4 aut |
700 | 1 | a Burney, Peter G. J.u Imperial Coll, Natl Heart & Lung Inst, London, England4 aut |
700 | 1 | a Amor, Caronu Imperial Coll, Natl Heart & Lung Inst, London, England4 aut |
700 | 1 | a Potts, Jamesu Imperial Coll, Natl Heart & Lung Inst, London, England4 aut |
700 | 1 | a Tumilty, Michaelu Imperial Coll, Natl Heart & Lung Inst, London, England4 aut |
700 | 1 | a McLean, Fionau Imperial Coll, Natl Heart & Lung Inst, London, England4 aut |
700 | 1 | a Wouters, E. F. M.u Maastricht Univ, Med Ctr, Maastricht, Netherlands4 aut |
700 | 1 | a Wesseling, G. J.u Maastricht Univ, Med Ctr, Maastricht, Netherlands4 aut |
700 | 1 | a Barbara, Cristinau Portuguese Soc Pneumol, Lisbon, Portugal4 aut |
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700 | 1 | a Olafsdottir, Inga Sifu Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)ingol425 |
700 | 1 | a Nisser, Katarinau Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)kanis030 |
700 | 1 | a Spetz-Nyström, Ulrikeu Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)ulrispet |
700 | 1 | a Hägg, Gunillau Uppsala universitet,Lung- allergi- och sömnforskning4 aut |
700 | 1 | a Lund, Gun-Marieu Uppsala universitet,Lung- allergi- och sömnforskning4 aut0 (Swepub:uu)gubod102 |
700 | 1 | a Jogi, Rainu Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut |
700 | 1 | a Laja, Hendriku Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut |
700 | 1 | a Ulst, Katrinu Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut |
700 | 1 | a Zobel, Vappuu Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut |
700 | 1 | a Lill, Toomas-Juliusu Tartu Univ Hosp, Lung Clin, Tartu, Estonia4 aut |
700 | 1 | a Koul, Parvaiz A.u Sherikashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India4 aut |
700 | 1 | a Malik, Sajjadu Sherikashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India4 aut |
700 | 1 | a Hakim, Nissar A.u Sherikashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India4 aut |
700 | 1 | a Khan, Umar Hafizu Sherikashmir Inst Med Sci, Srinagar, Jammu & Kashmir, India4 aut |
700 | 1 | a Chowgule, Rohiniu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Shetye, Vasantu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Raphael, Jonelleu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Almeda, Roselu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Tawde, Maheshu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Tadvi, Rafiqu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Katkar, Sunilu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Kadam, Milindu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Dhanawade, Rupeshu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Ghurup, Umeshu Indian Inst Environm Med, Mumbai, Maharashtra, India4 aut |
700 | 1 | a Harrabi, Imedu Fac Med, Sousse, Tunisia4 aut |
700 | 1 | a Denguezli, Myriamu Fac Med, Sousse, Tunisia4 aut |
700 | 1 | a Tabka, Zouhairu Fac Med, Sousse, Tunisia4 aut |
700 | 1 | a Daldoul, Hageru Fac Med, Sousse, Tunisia4 aut |
700 | 1 | a Boukheroufa, Zakiu Fac Med, Sousse, Tunisia4 aut |
700 | 1 | a Chouikha, Firasu Fac Med, Sousse, Tunisia4 aut |
700 | 1 | a Khalifa, Wahbi Belhaju Fac Med, Sousse, Tunisia4 aut |
700 | 1 | a Roa, Camilo C., Jr.u Philippine Coll Chest Phys, Manila, Philippines4 aut |
700 | 1 | a Ayuyao, Fernando G.u Philippine Gen Hosp, Lung Ctr Philippines, Nampicuan, Philippines4 aut |
700 | 1 | a Tady, Cecil Z.u Philippine Gen Hosp, Lung Ctr Philippines, Nampicuan, Philippines4 aut |
700 | 1 | a Tan, Daniel T.u Philippine Gen Hosp, Lung Ctr Philippines, Nampicuan, Philippines4 aut |
700 | 1 | a Banal-Yang, Sylviau Philippine Gen Hosp, Lung Ctr Philippines, Nampicuan, Philippines4 aut |
700 | 1 | a Balanag, Vincent M., Jr.u Philippine Gen Hosp, Lung Ctr Philippines, Nampicuan, Philippines4 aut |
700 | 1 | a Reyes, Maria Teresita N.u Philippine Gen Hosp, Lung Ctr Philippines, Nampicuan, Philippines4 aut |
700 | 1 | a Juvekar, Sanjayu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Hirve, Siddhiu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Sambhudas, Somnathu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Chaidhary, Bharatu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Tambe, Meerau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Pingale, Savitau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Umap, Aratiu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Umap, Archanau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Shelar, Nitinu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Devchakke, Sampadau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Chaudhary, Shardau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Bondre, Suvarnau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Walke, Savitau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Gawhane, Ashleshsau KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Sapkal, Anilu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Argade, Rupaliu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Gaikwad, Vijayu KEM Hosp Res Ctr Pune, Vadu Hlth & Demog Surveillance, Pune, Maharashtra, India4 aut |
700 | 1 | a Salvi, Sundeepu Chest Res Fdn, Pune, Maharashtra, India4 aut |
700 | 1 | a Brashier, Billu Chest Res Fdn, Pune, Maharashtra, India4 aut |
700 | 1 | a Londhe, Jyotiu Chest Res Fdn, Pune, Maharashtra, India4 aut |
700 | 1 | a Madas, Sapnau Chest Res Fdn, Pune, Maharashtra, India4 aut |
700 | 1 | a Obaseki, Danielu Obafemi Awolowo Univ, Ife, Nigeria4 aut |
700 | 1 | a Erhabor, Gregoryu Obafemi Awolowo Univ, Ife, Nigeria4 aut |
700 | 1 | a Awopeju, Olayemiu Obafemi Awolowo Univ, Ife, Nigeria4 aut |
700 | 1 | a Adewole, Olufemiu Obafemi Awolowo Univ, Ife, Nigeria4 aut |
710 | 2 | a Paracelsus Med Univ, Dept Pulm Med, Salzburg, Austriab Kepler Univ Hosp, Dept Pulmonol, Krankenhausstr 9, A-4021 Linz, Austria;Johannes Kepler Univ Linz, Fac Med, Linz, Austria;Paracelsus Med Univ, Inst Gen Practice Family Med & Prevent Med, Salzburg, Austria4 org |
773 | 0 | t Chestd : Elsevier BVg 156:2, s. 277-288q 156:2<277-288x 0012-3692x 1931-3543 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-393117 |
856 | 4 8 | u https://doi.org/10.1016/j.chest.2019.01.015 |
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