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Determination of thirteen antibiotics in drug products : a new LC-MS/MS tool for screening drug product quality

Oppong Bekoe, Samuel (author)
University of Copenhagen
Bak, Søren Alex (author)
University of Copenhagen
Björklund, Erland (author)
Environmental Analytical Laboratory,Miljöanalytiskt laboratorium (MoLab),Högskolan Kristianstad, Plattformen för molekylär analys,Högskolan Kristianstad, Plattformen för molekylär analys
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Krogh, Kristine A. (author)
University of Copenhagen
Okine, Nathaniel N. N. A. (author)
Kwame Nkrumah University of Science and Technology
Adosraku, Reimmiel K. (author)
Kwame Nkrumah University of Science and Technology
Styrishave, Bjarne (author)
University of Copenhagen
Hansen, Martin (author)
University of Copenhagen
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 (creator_code:org_t)
Royal Society of Chemistry, 2014
2014
English 8
In: Analytical Methods. - : Royal Society of Chemistry. - 1759-9660 .- 1759-9679. ; 6, s. 5847-5855
Related links:
https://doi.org/10.1...
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

Subject headings

NATURVETENSKAP  -- Kemi -- Analytisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Analytical Chemistry (hsv//eng)

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