Search: WFRF:(Hansson Johan 1964 )
> (2015-2019) >
Sentinel node detec...
Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report
-
- Rosenblatt, Robert (author)
- Umeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden
-
- Johansson, Markus (author)
- Sundsvall Hosp, Dept Urol, Sundsvall, Sweden
-
- Alamdari, Farhood (author)
- Vastmanland Hosp, Dept Urol, Vasteras, Sweden
-
show more...
-
- Sidiki, Alexander (author)
- Lanssjukhuset Ryhov, Dept Urol, Jonkoping, Sweden
-
- Holmström, Benny (author)
- Uppsala universitet,Urologkirurgi
-
- Hansson, Johan, 1964- (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg
-
- Vasko, Janos (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden
-
- Marits, Per (author)
- Karolinska Institutet
-
- Gabrielsson, Susanne (author)
- Karolinska Institutet
-
- Riklund, Katrine (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umea Univ, Dept Radiat Sci, Umea, Sweden
-
- Winqvist, Ola (author)
- Karolinska Institutet
-
- Sherif, Amir (author)
- Umeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, S-90185 Umea, Sweden
-
show less...
-
(creator_code:org_t)
- 2016-10-13
- 2017
- English.
-
In: World journal of urology. - : Springer Science and Business Media LLC. - 0724-4983 .- 1433-8726. ; 35:6, s. 921-927
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://link.springe...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- PURPOSE: To determine whether sentinel node detection (SNd) in muscle-invasive urothelial bladder cancer (MIBC) can be performed in patients undergoing neoadjuvant chemotherapy (NAC) and determine whether SNd is feasible in all pT stages, including pT0.BACKGROUND: Previous published series of SNd in MIBC have not included patients undergoing NAC, and systematic reports of pT0 patients w/wo NAC were absent. Translational immunological tumor research on MIBC focusing on SNd, in the era of NAC, requires technical feasibility. Additionally, SNd in MIBC requests further evaluations as a method for nodal staging.MATERIALS AND METHODS: Ninety-nine patients with suspected urothelial MIBC were prospectively selected from six urological centers. After TUR-B and primary staging, 65 MIBC patients qualified for radical cystectomy. Precystectomy staging was cT2a-T4aN0M0, including 47 NAC patients and 18 chemo-naïve patients. All 65 patients underwent intraoperative SNd by peritumoral injection of 80 Mbq Technetium and Geiger probe detection. Postcystectomy staging was pT0-T4aN0-N2M0. SNs were defined by two calculations, SNdef1 and SNdef2.RESULTS: Totally 1063 lymph nodes were removed (total SNs; 222-227). NAC patients with pT0 (n = 24) displayed a true positive detection in 91.7 % by either SNdef, with a median of 3.0 SNs. NACpT >0 patients had a true positive detection in 87 % (SNdef1) and 91.3 % (SNdef2). In a univariate analysis, patient group neither NAC nor tumor downstaging influenced detection rates, regardless of SN definition. In total eight patients, 4/22 metastatic nodes were SNs while 18/22 were non-SNs.CONCLUSIONS: Sentinel node detection in MIBC is feasible also in NAC patients, regardless of pT stage. SNd played no role in nodal staging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Urinary bladder neoplasms
- Neoadjuvant therapy
- Cisplatin
- Sentinel lymph node biopsy
- Cystectomy
- Immunotherapy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rosenblatt, Robe ...
-
Johansson, Marku ...
-
Alamdari, Farhoo ...
-
Sidiki, Alexande ...
-
Holmström, Benny
-
Hansson, Johan, ...
-
show more...
-
Vasko, Janos
-
Marits, Per
-
Gabrielsson, Sus ...
-
Riklund, Katrine
-
Winqvist, Ola
-
Sherif, Amir
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
- Articles in the publication
-
World journal of ...
- By the university
-
Umeå University
-
Uppsala University
-
Karolinska Institutet