WFRF:(Harder C. B.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04646naa a2201105 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:148678472 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1486784722 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-021-00990-02 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hautakangas, H4 aut |
| 245 | 1 0 | a Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles |
| 264 | c 2022-02-03 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology. | |
| 700 | 1 | a Winsvold, BS4 aut |
| 700 | 1 | a Ruotsalainen, SE4 aut |
| 700 | 1 | a Bjornsdottir, G4 aut |
| 700 | 1 | a Harder, AVE4 aut |
| 700 | 1 | a Kogelman, LJA4 aut |
| 700 | 1 | a Thomas, LF4 aut |
| 700 | 1 | a Noordam, R4 aut |
| 700 | 1 | a Benner, C4 aut |
| 700 | 1 | a Gormley, P4 aut |
| 700 | 1 | a Artto, V4 aut |
| 700 | 1 | a Banasik, K4 aut |
| 700 | 1 | a Bjornsdottir, A4 aut |
| 700 | 1 | a Boomsma, D4 aut |
| 700 | 1 | a Brumpton, B4 aut |
| 700 | 1 | a Burgdorf, KS4 aut |
| 700 | 1 | a Buring, JE4 aut |
| 700 | 1 | a Chalmer, MA4 aut |
| 700 | 1 | a de Boer, I4 aut |
| 700 | 1 | a Dichgans, M4 aut |
| 700 | 1 | a Erikstrup, C4 aut |
| 700 | 1 | a Farkkila, M4 aut |
| 700 | 1 | a Garbrielsen, ME4 aut |
| 700 | 1 | a Ghanbari, M4 aut |
| 700 | 1 | a Hagen, K4 aut |
| 700 | 1 | a Happola, P4 aut |
| 700 | 1 | a Hottenga, JJ4 aut |
| 700 | 1 | a Hrafnsdottir, MG4 aut |
| 700 | 1 | a Hveem, K4 aut |
| 700 | 1 | a Johnsen, MB4 aut |
| 700 | 1 | a Kahonen, M4 aut |
| 700 | 1 | a Kristoffersen, ES4 aut |
| 700 | 1 | a Kurth, T4 aut |
| 700 | 1 | a Lehtimaki, T4 aut |
| 700 | 1 | a Lighart, L4 aut |
| 700 | 1 | a Magnusson, SH4 aut |
| 700 | 1 | a Malik, R4 aut |
| 700 | 1 | a Pedersen, OB4 aut |
| 700 | 1 | a Pelzer, N4 aut |
| 700 | 1 | a Penninx, BWJH4 aut |
| 700 | 1 | a Ran, Cu Karolinska Institutet4 aut |
| 700 | 1 | a Ridker, PM4 aut |
| 700 | 1 | a Rosendaal, FR4 aut |
| 700 | 1 | a Sigurdardottir, GR4 aut |
| 700 | 1 | a Skogholt, AH4 aut |
| 700 | 1 | a Sveinsson, OA4 aut |
| 700 | 1 | a Thorgeirsson, TE4 aut |
| 700 | 1 | a Ullum, H4 aut |
| 700 | 1 | a Vijfhuizen, LS4 aut |
| 700 | 1 | a Widen, E4 aut |
| 700 | 1 | a van Dijk, KW4 aut |
| 700 | 1 | a Aromaa, A4 aut |
| 700 | 1 | a Belin, ACu Karolinska Institutet4 aut |
| 700 | 1 | a Freilinger, T4 aut |
| 700 | 1 | a Ikram, MA4 aut |
| 700 | 1 | a Jarvelin, MR4 aut |
| 700 | 1 | a Raitakari, OT4 aut |
| 700 | 1 | a Terwindt, GM4 aut |
| 700 | 1 | a Kallela, M4 aut |
| 700 | 1 | a Wessman, M4 aut |
| 700 | 1 | a Olesen, J4 aut |
| 700 | 1 | a Chasman, D4 aut |
| 700 | 1 | a Nyholt, DR4 aut |
| 700 | 1 | a Stefansson, H4 aut |
| 700 | 1 | a Stefansson, K4 aut |
| 700 | 1 | a van den Maagdenberg, AMJM4 aut |
| 700 | 1 | a Hansen, TF4 aut |
| 700 | 1 | a Ripatti, S4 aut |
| 700 | 1 | a Zwart, JA4 aut |
| 700 | 1 | a Palotie, A4 aut |
| 700 | 1 | a Pirinen, M4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature geneticsd : Springer Science and Business Media LLCg 54:2, s. 152-+q 54:2<152-+x 1546-1718x 1061-4036 |
| 856 | 4 | u https://www.nature.com/articles/s41588-021-00990-0.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148678472 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-021-00990-0 |
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- Hautakangas, H
- Winsvold, BS
- Ruotsalainen, SE
- Bjornsdottir, G
- Harder, AVE
- Kogelman, LJA
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- Thomas, LF
- Noordam, R
- Benner, C
- Gormley, P
- Artto, V
- Banasik, K
- Bjornsdottir, A
- Boomsma, D
- Brumpton, B
- Burgdorf, KS
- Buring, JE
- Chalmer, MA
- de Boer, I
- Dichgans, M
- Erikstrup, C
- Farkkila, M
- Garbrielsen, ME
- Ghanbari, M
- Hagen, K
- Happola, P
- Hottenga, JJ
- Hrafnsdottir, MG
- Hveem, K
- Johnsen, MB
- Kahonen, M
- Kristoffersen, E ...
- Kurth, T
- Lehtimaki, T
- Lighart, L
- Magnusson, SH
- Malik, R
- Pedersen, OB
- Pelzer, N
- Penninx, BWJH
- Ran, C
- Ridker, PM
- Rosendaal, FR
- Sigurdardottir, ...
- Skogholt, AH
- Sveinsson, OA
- Thorgeirsson, TE
- Ullum, H
- Vijfhuizen, LS
- Widen, E
- van Dijk, KW
- Aromaa, A
- Belin, AC
- Freilinger, T
- Ikram, MA
- Jarvelin, MR
- Raitakari, OT
- Terwindt, GM
- Kallela, M
- Wessman, M
- Olesen, J
- Chasman, D
- Nyholt, DR
- Stefansson, H
- Stefansson, K
- van den Maagdenb ...
- Hansen, TF
- Ripatti, S
- Zwart, JA
- Palotie, A
- Pirinen, M
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