Search: WFRF:(Hatschek T.)
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Coronary heart dise...
Coronary heart disease mortality after 5 years of adjuvant tamoxifen therapy: results from a randomized trial
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- Nordenskjöld, Bo, 1940- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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- Rosell, Johan, 1966- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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- Rutqvist, L. E. (author)
- Department of Oncology, Södersjukhuset Hospital, Stockholm, Sweden
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- Malmström, Per (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Oncology, Lund University Hospital, Lund, Sweden
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- Bergh, J. (author)
- Karolinska Institutet,Department of Oncology, Karolinska Hospital, Stockholm, Sweden
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- Bengtsson, Nils-Olof (author)
- Umeå universitet,Onkologi,Department of Oncology, Umeå University Hospital, Umeå, Sweden
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- Hatschek, T. (author)
- Karolinska Institutet,Department of Oncology, Karolinska Hospital, Stockholm, Sweden
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- Wallgren, Arne, 1940 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology,Department of Oncology, Sahlgrenska University Hospital, Göteborg, Sweden
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- Carstensen, John, 1953- (author)
- Linköpings universitet,Filosofiska fakulteten,Tema hälsa och samhälle
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(creator_code:org_t)
- Oxford University Press (OUP), 2005
- 2005
- English.
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In: J Natl Cancer Inst. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 97:21, s. 1609-10
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Abstract
Subject headings
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- From January 1, 1983, through December 31, 1992, a total of 4610 patients entered a randomized trial that compared mortality among patients receiving 2 years of adjuvant tamoxifen therapy with that in patients receiving 5 years of adjuvant tamoxifen therapy, 4175 of whom were recurrence free after 2 years of tamoxifen therapy. Among the 2046 patients randomly assigned to the 5-year group all-cause mortality, breast cancer-specific mortality, and the incidence of contralateral breast cancer were reduced, compared with those among 2129 patients randomized in the 2-year group, but the incidence of endometrial cancer was increased. In addition, mortality from coronary heart disease was statistically significantly reduced in the 5-year group, compared with that in the 2-year group (hazard ratio = 0.67, 95% confidence interval = 0.47 to 0.94; P = .022 [two-sided Wald test]). Ten years after surgery, 2.1% of the patients in the 5-year group and 3.5% of those in the 2-year group had died from coronary heart disease. No statistically significant increases in mortality from other heart diseases, cerebrovascular diseases, or other vascular diseases were observed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Aged
- Antineoplastic Agents
- Hormonal/*administration & dosage
- Breast Neoplasms/*drug therapy/prevention & control
- Chemotherapy
- Adjuvant
- Coronary Disease/*mortality
- Drug Administration Schedule
- Estrogen Receptor Modulators/*administration & dosage
- Female
- Humans
- Incidence
- Middle Aged
- Mortality/trends
- Odds Ratio
- Postmenopause
- Proportional Hazards Models
- Registries
- Sweden/epidemiology
- Tamoxifen/*administration & dosage
- Time Factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nordenskjöld, Bo ...
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Rosell, Johan, 1 ...
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Rutqvist, L. E.
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Malmström, Per
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Bergh, J.
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Bengtsson, Nils- ...
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Hatschek, T.
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Wallgren, Arne, ...
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Carstensen, John ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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J Natl Cancer In ...
- By the university
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University of Gothenburg
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Lund University
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Umeå University
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Karolinska Institutet
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Linköping University