Sökning: WFRF:(Hogendoorn Pancras C. W.) > GRM1 is upregulated...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04393naa a2200493 4500 | |
001 | oai:DiVA.org:su-104402 | |
003 | SwePub | |
008 | 140610s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:5a2dd6e2-ef7c-492e-9833-9a282f71621e | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1044022 URI |
024 | 7 | a https://doi.org/10.1038/ng.29272 DOI |
024 | 7 | a https://lup.lub.lu.se/record/43798862 URI |
040 | a (SwePub)sud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hansén Nord, Karolinu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)klin-kha |
245 | 1 0 | a GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma |
264 | c 2014-03-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2014 |
338 | a print2 rdacarrier | |
500 | a AuthorCount:10; | |
520 | a Glutamate receptors are well-known actors in the central and peripheral nervous systems, and altered glutamate signaling is implicated in several neurological and psychiatric disorders. It is increasingly recognized that such receptors may also have a role in tumor growth. Here we provide direct evidence of aberrant glutamate signaling in the development of a locally aggressive bone tumor, chondromyxoid fibroma (CMF). We subjected a series of CMFs to whole-genome mate-pair sequencing and RNA sequencing and found that the glutamate receptor gene GRM1 recombines with several partner genes through promoter swapping and gene fusion events. The GRM1 coding region remains intact, and 18 of 20 CMFs (90%) showed a more than 100-fold and up to 1,400-fold increase in GRM1 expression levels compared to control tissues. Our findings unequivocally demonstrate that direct targeting of GRM1 is a necessary and highly specific driver event for CMF development. | |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Lilljebjörn, Henriku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)tmb-hli |
700 | 1 | a Vezzi, Francescou Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)4 aut0 (Swepub:su)fvezz |
700 | 1 | a Nilsson, Jennyu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-jno |
700 | 1 | a Magnusson, Lindau Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)mphy-lma |
700 | 1 | a Tayebwa, Johnboscou Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-jta |
700 | 1 | a de Jong, Danielle4 aut |
700 | 1 | a Bovee, Judith V. M. G.4 aut |
700 | 1 | a Hogendoorn, Pancras C. W.4 aut |
700 | 1 | a Szuhai, Karoly4 aut |
710 | 2 | a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 46:5, s. 474-477q 46:5<474-477x 1061-4036x 1546-1718 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24658000?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1038/ng.2927y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-104402 |
856 | 4 8 | u https://doi.org/10.1038/ng.2927 |
856 | 4 8 | u https://lup.lub.lu.se/record/4379886 |
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