Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

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Fältnamn	Indikatorer	Metadata
000		10813naa a2202473 4500
001		oai:lup.lub.lu.se:d0d3004b-b1de-4b6c-bae9-a9dcd7640311
003		SwePub
008		160401s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:gup.ub.gu.se/150589
009		oai:DiVA.org:uu-167661
024	7	a https://lup.lub.lu.se/record/23333592 URI
024	7	a https://doi.org/10.1371/journal.pbio.10011992 DOI
024	7	a https://gup.ub.gu.se/publication/1505892 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1676612 URI
040		a (SwePub)lud (SwePub)gud (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Maxwell, Christopher A.4 aut
245	1 0	a Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer
264		c 2011-11-15
264	1	b Public Library of Science (PLoS),c 2011
338		a electronic2 rdacarrier
520		a Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02-1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94-1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM.
650	7	a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653		a Genetic Predisposition to Disease
653		a BRCA2
653		a BRCA1
653		a Genes
653		a Female
653		a Extracellular Matrix Proteins
653		a Epithelial Cells
653		a Cell Polarity
653		a Tumor
653		a Cell Line
653		a Breast Neoplasms
653		a Breast
653		a BRCA2 Protein
653		a CD44
653		a Antigens
653		a BRCA1 Protein
653		a Genetic Variation
653		a Genotype
653		a HeLa Cells
653		a Heterozygote
653		a Humans
653		a Microtubules
653		a Protein-Serine-Threonine Kinases
653		a Receptors
653		a Estrogen
700	1	a Benitez, Javier4 aut
700	1	a Gomez-Baldo, Laia4 aut
700	1	a Osorio, Ana4 aut
700	1	a Bonifaci, Nuria4 aut
700	1	a Fernandez-Ramires, Ricardo4 aut
700	1	a Costes, Sylvain V.4 aut
700	1	a Guino, Elisabet4 aut
700	1	a Chen, Helen4 aut
700	1	a Evans, Gareth J. R.4 aut
700	1	a Mohan, Pooja4 aut
700	1	a Catala, Isabel4 aut
700	1	a Petit, Anna4 aut
700	1	a Aguilar, Helena4 aut
700	1	a Villanueva, Alberto4 aut
700	1	a Aytes, Alvaro4 aut
700	1	a Serra-Musach, Jordi4 aut
700	1	a Rennert, Gad4 aut
700	1	a Lejbkowicz, Flavio4 aut
700	1	a Peterlongo, Paolo4 aut
700	1	a Manoukian, Siranoush4 aut
700	1	a Peissel, Bernard4 aut
700	1	a Ripamonti, Carla B.4 aut
700	1	a Bonanni, Bernardo4 aut
700	1	a Viel, Alessandra4 aut
700	1	a Allavena, Anna4 aut
700	1	a Bernard, Loris4 aut
700	1	a Radice, Paolo4 aut
700	1	a Friedman, Eitan4 aut
700	1	a Kaufman, Bella4 aut
700	1	a Laitman, Yael4 aut
700	1	a Dubrovsky, Maya4 aut
700	1	a Milgrom, Roni4 aut
700	1	a Jakubowska, Anna4 aut
700	1	a Cybulski, Cezary4 aut
700	1	a Gorski, Bohdan4 aut
700	1	a Jaworska, Katarzyna4 aut
700	1	a Durda, Katarzyna4 aut
700	1	a Sukiennicki, Grzegorz4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Shugart, Yin Yao4 aut
700	1	a Domchek, Susan M.4 aut
700	1	a Letrero, Richard4 aut
700	1	a Weber, Barbara L.4 aut
700	1	a Hogervorst, Frans B. L.4 aut
700	1	a Rookus, Matti A.4 aut
700	1	a Collee, J. Margriet4 aut
700	1	a Devilee, Peter4 aut
700	1	a Ligtenberg, Marjolijn J.4 aut
700	1	a van der Luijt, Rob B.4 aut
700	1	a Aalfs, Cora M.4 aut
700	1	a Waisfisz, Quinten4 aut
700	1	a Wijnen, Juul4 aut
700	1	a van Roozendaal, Cornelis E. P.4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Peock, Susan4 aut
700	1	a Cook, Margaret4 aut
700	1	a Oliver, Clare4 aut
700	1	a Frost, Debra4 aut
700	1	a Harrington, Patricia4 aut
700	1	a Evans, D. Gareth4 aut
700	1	a Lalloo, Fiona4 aut
700	1	a Eeles, Rosalind4 aut
700	1	a Izatt, Louise4 aut
700	1	a Chu, Carol4 aut
700	1	a Eccles, Diana4 aut
700	1	a Douglas, Fiona4 aut
700	1	a Brewer, Carole4 aut
700	1	a Nevanlinna, Heli4 aut
700	1	a Heikkinen, Tuomas4 aut
700	1	a Couch, Fergus J.4 aut
700	1	a Lindor, Noralane M.4 aut
700	1	a Wang, Xianshu4 aut
700	1	a Godwin, Andrew K.4 aut
700	1	a Caligo, Maria A.4 aut
700	1	a Lombardi, Grazia4 aut
700	1	a Loman, Niklasu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-nlo
700	1	a Karlsson, Per,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xkperd
700	1	a Ehrencrona, Hansu Uppsala universitet,Uppsala University,Medicinsk genetik4 aut0 (Swepub:uu)habos227
700	1	a von Wachenfeldt, Anna4 aut
700	1	a Barkardottir, Rosa Bjork4 aut
700	1	a Hamann, Ute4 aut
700	1	a Rashid, Muhammad U.4 aut
700	1	a Lasa, Adriana4 aut
700	1	a Caldes, Trinidad4 aut
700	1	a Andres, Raquel4 aut
700	1	a Schmitt, Michael4 aut
700	1	a Assmann, Volker4 aut
700	1	a Stevens, Kristen4 aut
700	1	a Offit, Kenneth4 aut
700	1	a Curado, Joao4 aut
700	1	a Tilgner, Hagen4 aut
700	1	a Guigo, Roderic4 aut
700	1	a Aiza, Gemma4 aut
700	1	a Brunet, Joan4 aut
700	1	a Castellsague, Joan4 aut
700	1	a Martrat, Griselda4 aut
700	1	a Urruticoechea, Ander4 aut
700	1	a Blanco, Ignacio4 aut
700	1	a Tihomirova, Laima4 aut
700	1	a Goldgar, David E.4 aut
700	1	a Buys, Saundra4 aut
700	1	a John, Esther M.4 aut
700	1	a Miron, Alexander4 aut
700	1	a Southey, Melissa4 aut
700	1	a Daly, Mary B.4 aut
700	1	a Schmutzler, Rita K.4 aut
700	1	a Wappenschmidt, Barbara4 aut
700	1	a Meindl, Alfons4 aut
700	1	a Arnold, Norbert4 aut
700	1	a Deissler, Helmut4 aut
700	1	a Varon-Mateeva, Raymonda4 aut
700	1	a Sutter, Christian4 aut
700	1	a Niederacher, Dieter4 aut
700	1	a Imyamitov, Evgeny4 aut
700	1	a Sinilnikova, Olga M.4 aut
700	1	a Stoppa-Lyonne, Dominique4 aut
700	1	a Mazoyer, Sylvie4 aut
700	1	a Verny-Pierre, Carole4 aut
700	1	a Castera, Laurent4 aut
700	1	a de Pauw, Antoine4 aut
700	1	a Bignon, Yves-Jean4 aut
700	1	a Uhrhammer, Nancy4 aut
700	1	a Peyrat, Jean-Philippe4 aut
700	1	a Vennin, Philippe4 aut
700	1	a Ferrer, Sandra Fert4 aut
700	1	a Collonge-Rame, Marie-Agnes4 aut
700	1	a Mortemousque, Isabelle4 aut
700	1	a Spurdle, Amanda B.4 aut
700	1	a Beesley, Jonathan4 aut
700	1	a Chen, Xiaoqing4 aut
700	1	a Healey, Sue4 aut
700	1	a Barcellos-Hoff, Mary Helen4 aut
700	1	a Vidal, Marc4 aut
700	1	a Gruber, Stephen B.4 aut
700	1	a Lazaro, Conxi4 aut
700	1	a Capella, Gabriel4 aut
700	1	a McGuffog, Lesley4 aut
700	1	a Nathanson, Katherine L.4 aut
700	1	a Antoniou, Antonis C.4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Fleisch, Markus C.4 aut
700	1	a Moreno, Victor4 aut
700	1	a Angel Pujana, Miguel4 aut
710	2	a Bröstcancer-genetikb Sektion I4 org
773	0	t PLoS Biologyd : Public Library of Science (PLoS)g 9:11q 9:11x 1545-7885x 1544-9173
856	4	u https://portal.research.lu.se/files/4262544/2369646.pdfx primaryx freey FULLTEXT
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/22110403x freey FULLTEXT
856	4	u http://dx.doi.org/10.1371/journal.pbio.1001199x freey FULLTEXT
856	4	u https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001199&type=printable
856	4 8	u https://lup.lub.lu.se/record/2333359
856	4 8	u https://doi.org/10.1371/journal.pbio.1001199
856	4 8	u https://gup.ub.gu.se/publication/150589
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167661

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Av författaren/redakt...: Maxwell, Christo ...; Benitez, Javier; Gomez-Baldo, Lai ...; Osorio, Ana; Bonifaci, Nuria; Fernandez-Ramire ...; visa fler...; Costes, Sylvain ...; Guino, Elisabet; Chen, Helen; Evans, Gareth J. ...; Mohan, Pooja; Catala, Isabel; Petit, Anna; Aguilar, Helena; Villanueva, Albe ...; Aytes, Alvaro; Serra-Musach, Jo ...; Rennert, Gad; Lejbkowicz, Flav ...; Peterlongo, Paol ...; Manoukian, Siran ...; Peissel, Bernard; Ripamonti, Carla ...; Bonanni, Bernard ...; Viel, Alessandra; Allavena, Anna; Bernard, Loris; Radice, Paolo; Friedman, Eitan; Kaufman, Bella; Laitman, Yael; Dubrovsky, Maya; Milgrom, Roni; Jakubowska, Anna; Cybulski, Cezary; Gorski, Bohdan; Jaworska, Katarz ...; Durda, Katarzyna; Sukiennicki, Grz ...; Lubinski, Jan; Shugart, Yin Yao; Domchek, Susan M ...; Letrero, Richard; Weber, Barbara L ...; Hogervorst, Fran ...; Rookus, Matti A.; Collee, J. Margr ...; Devilee, Peter; Ligtenberg, Marj ...; van der Luijt, R ...; Aalfs, Cora M.; Waisfisz, Quinte ...; Wijnen, Juul; van Roozendaal, ...; Easton, Douglas ...; Peock, Susan; Cook, Margaret; Oliver, Clare; Frost, Debra; Harrington, Patr ...; Evans, D. Gareth; Lalloo, Fiona; Eeles, Rosalind; Izatt, Louise; Chu, Carol; Eccles, Diana; Douglas, Fiona; Brewer, Carole; Nevanlinna, Heli; Heikkinen, Tuoma ...; Couch, Fergus J.; Lindor, Noralane ...; Wang, Xianshu; Godwin, Andrew K ...; Caligo, Maria A.; Lombardi, Grazia; Loman, Niklas; Karlsson, Per, 1 ...; Ehrencrona, Hans; von Wachenfeldt, ...; Barkardottir, Ro ...; Hamann, Ute; Rashid, Muhammad ...; Lasa, Adriana; Caldes, Trinidad; Andres, Raquel; Schmitt, Michael; Assmann, Volker; Stevens, Kristen; Offit, Kenneth; Curado, Joao; Tilgner, Hagen; Guigo, Roderic; Aiza, Gemma; Brunet, Joan; Castellsague, Jo ...; Martrat, Griseld ...; Urruticoechea, A ...; Blanco, Ignacio; Tihomirova, Laim ...; Goldgar, David E ...; Buys, Saundra; John, Esther M.; Miron, Alexander; Southey, Melissa; Daly, Mary B.; Schmutzler, Rita ...; Wappenschmidt, B ...; Meindl, Alfons; Arnold, Norbert; Deissler, Helmut; Varon-Mateeva, R ...; Sutter, Christia ...; Niederacher, Die ...; Imyamitov, Evgen ...; Sinilnikova, Olg ...; Stoppa-Lyonne, D ...; Mazoyer, Sylvie; Verny-Pierre, Ca ...; Castera, Laurent; de Pauw, Antoine; Bignon, Yves-Jea ...; Uhrhammer, Nancy; Peyrat, Jean-Phi ...; Vennin, Philippe; Ferrer, Sandra F ...; Collonge-Rame, M ...; Mortemousque, Is ...; Spurdle, Amanda ...; Beesley, Jonatha ...; Chen, Xiaoqing; Healey, Sue; Barcellos-Hoff, ...; Vidal, Marc; Gruber, Stephen ...; Lazaro, Conxi; Capella, Gabriel; McGuffog, Lesley; Nathanson, Kathe ...; Antoniou, Antoni ...; Chenevix-Trench, ...; Fleisch, Markus ...; Moreno, Victor; Angel Pujana, Mi ...; visa färre...

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