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Apolipoprotein A-I–...
Apolipoprotein A-I–Derived Amyloid in Atherosclerosis : Its Association With Plasma Levels of Apolipoprotein A-I and Cholesterol
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- Mucchiano, Gerd I. (författare)
- Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
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- Jonasson, Lena (författare)
- Department of Medicine, Högland Hospital, Eksjö
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- Häggqvist, Bo, 1962- (författare)
- Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
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- Einarsson, Eibert (författare)
- Department of Surgery, Högland Hospital, Eksjö
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- Westermark, Per (författare)
- Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: American Journal of Clinical Pathology. - 0002-9173 .- 1943-7722. ; 115, s. 298-303
- Relaterad länk:
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http://ajcp.ascpjour...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Wild-type apolipoprotein A-I (apo A-I)–derived amyloid commonly occurs in atherosclerotic plaques. To clarify apo A-I amyloid formation, plasma levels of apo A-I and cholesterol were related to the presence of amyloid in atherosclerotic plaques in 15 patients with peripheral atherosclerosis, subjected to arterial reconstruction. Plasma levels of apo A-I and high-density lipoprotein (HDL) cholesterol were slightly higher in patients with apo A-I–derived amyloid than in those without, but the difference was not significant. Levels of low-density lipoprotein cholesterol and total cholesterol were significantly higher in the group with amyloid. High concentrations of apo A-I in the arterial intima are probably of greater importance to amyloid formation than high plasma levels of the protein. During atherosclerosis, the acute phase reactant serum amyloid A may displace apo A-I from HDL, leading to increased concentration of lipid-free apo A-I in the intima and conformational changes of apo A-I, which make it more fibrillogenic. Some forms of amyloid fibrils have been shown to be cytotoxic. Apo AI–derived amyloid is possibly a pathogenically important factor in atherosclerosis.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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