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  • Bergmann, OlafKarolinska Institutet (author)

Evidence for Cardiomyocyte Renewal in Humans

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • American Association for the Advancement of Science (AAAS),2009

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:d648a19e-6595-4eb3-a302-196ec926bd39
  • https://lup.lub.lu.se/record/1401336URI
  • https://doi.org/10.1126/science.1164680DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118522172URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bhardwaj, Ratan D. (author)
  • Bernard, Samuel (author)
  • Zdunek, Sofia (author)
  • Barnabe-Heider, FanieKarolinska Institutet (author)
  • Walsh, StuartLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)stem-swa (author)
  • Zupicich, Joel (author)
  • Alkass, KanarKarolinska Institutet (author)
  • Buchholz, Bruce A. (author)
  • Druid, HenrikKarolinska Institutet (author)
  • Jovinge, StefanLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)medf-sjo (author)
  • Frisen, JonasKarolinska Institutet (author)
  • Karolinska InstitutetStamcellscentrum (SCC) (creator_code:org_t)

Related titles

  • In:Science: American Association for the Advancement of Science (AAAS)324:5923, s. 98-1021095-92030036-8075

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