Sökning: WFRF:(Kanar Alkass) > Evidence for Cardio...
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000 | 03409naa a2200457 4500 | |
001 | oai:lup.lub.lu.se:d648a19e-6595-4eb3-a302-196ec926bd39 | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:118522172 | |
024 | 7 | a https://lup.lub.lu.se/record/14013362 URI |
024 | 7 | a https://doi.org/10.1126/science.11646802 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1185221722 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Bergmann, Olafu Karolinska Institutet4 aut |
245 | 1 0 | a Evidence for Cardiomyocyte Renewal in Humans |
264 | 1 | b American Association for the Advancement of Science (AAAS),c 2009 |
520 | a It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Bhardwaj, Ratan D.4 aut |
700 | 1 | a Bernard, Samuel4 aut |
700 | 1 | a Zdunek, Sofia4 aut |
700 | 1 | a Barnabe-Heider, Fanieu Karolinska Institutet4 aut |
700 | 1 | a Walsh, Stuartu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)stem-swa |
700 | 1 | a Zupicich, Joel4 aut |
700 | 1 | a Alkass, Kanaru Karolinska Institutet4 aut |
700 | 1 | a Buchholz, Bruce A.4 aut |
700 | 1 | a Druid, Henriku Karolinska Institutet4 aut |
700 | 1 | a Jovinge, Stefanu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)medf-sjo |
700 | 1 | a Frisen, Jonasu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Stamcellscentrum (SCC)4 org |
773 | 0 | t Scienced : American Association for the Advancement of Science (AAAS)g 324:5923, s. 98-102q 324:5923<98-102x 1095-9203x 0036-8075 |
856 | 4 | u http://dx.doi.org/10.1126/science.1164680y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc2991140?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/1401336 |
856 | 4 8 | u https://doi.org/10.1126/science.1164680 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118522172 |
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