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- Pratt, G DUniversity of Zurich (author)
Differential regulation of N-methyl-D-aspartate receptor subunit messenger RNAs in kindling-induced epileptogenesis
- Article/chapterEnglish1993
Publisher, publication year, extent ...
- 1993
- 12 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:dccfa3fd-dc30-4e08-8773-fedc664b9f41
- https://lup.lub.lu.se/record/dccfa3fd-dc30-4e08-8773-fedc664b9f41URI
- https://doi.org/10.1016/0306-4522(93)90064-MDOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- N-methyl-D-aspartate-receptors are implicated in several neuropathological conditions including epilepsy. As a model of complex partial seizures, rapid hippocampal kindling was chosen to investigate changes in the expression of messenger RNAs encoding the N-methyl-D-aspartate-receptor subunits NR1, NR2A and NR2B both during and in the period immediately following the induction of the kindled state. The study demonstrates a cell-specific, time-dependent modulation of the N-methyl-D-aspartate-receptor subunit messenger RNAs almost entirely restricted to the granule cells of the dentate gyrus. In partially kindled animals (10 stimulations), while the NR1 subunit messenger RNA remained unaltered after a period of 2 h, the NR2A and NR2B subunit messenger RNAs were bilaterally reduced in dentate gyrus granule cells by around 50% below control values. In fully kindled animals (40 stimulations), a progressive reduction in NR1 subunit messenger RNA levels in the dentate gyrus was observed, being maximal after 4 h (-67%). At the same time point, NR2A and NR2B transcript levels were transiently increased by 102% and 46% above control values, respectively. These data point to a differential regulation of N-methyl-D-aspartate-receptor subunit messenger RNAs. No alterations were detected in pyramidal cells. Long-term maintenance of the kindled state was not associated with alterations in N-methyl-D-aspartate-receptor subunit messenger RNAs since control levels of messenger RNA were attained by 12 h and persisted for at least five days. The early changes in messenger RNAs described in this study indicate that the expression of N-methyl-D-aspartate-receptor subunits is under independent regulatory control. This phenomenon may contribute to epileptogenesis and to kindling-associated plasticity by mediating a structural reorganization of N-methyl-D-aspartate-receptors, leading to an altered excitability of dentate gyrus granule cells.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Animals
- Autoradiography
- Down-Regulation/physiology
- Epilepsy/metabolism
- Hippocampus/anatomy & histology
- In Situ Hybridization
- Kindling, Neurologic
- Male
- Oligonucleotide Probes
- RNA, Messenger/biosynthesis
- Rats
- Rats, Sprague-Dawley
- Receptors, N-Methyl-D-Aspartate/metabolism
Added entries (persons, corporate bodies, meetings, titles ...)
- Kokaia, MLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-mko (author)
- Bengzon, JLund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurokirurgi,Institutionen för kliniska vetenskaper, Lund,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurosurgery,Department of Clinical Sciences, Lund(Swepub:lu)neur-jbe (author)
- Kokaia, ZLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-zko (author)
- Fritschy, J MUniversity of Zurich (author)
- Möhler, HUniversity of Zurich (author)
- Lindvall, OLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-oli (author)
- University of ZurichNeurologi, Lund (creator_code:org_t)
Related titles
- In:Neuroscience57:2, s. 18-3070306-4522
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