WFRF:(Kokaia Z)
Sökning: WFRF:(Kokaia Z) > Differential regula...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05023naa a2200517 4500 | |
| 001 | oai:lup.lub.lu.se:dccfa3fd-dc30-4e08-8773-fedc664b9f41 | |
| 003 | SwePub | |
| 008 | 190625s1993 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/dccfa3fd-dc30-4e08-8773-fedc664b9f412 URI |
| 024 | 7 | a https://doi.org/10.1016/0306-4522(93)90064-M2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Pratt, G Du University of Zurich4 aut |
| 245 | 1 0 | a Differential regulation of N-methyl-D-aspartate receptor subunit messenger RNAs in kindling-induced epileptogenesis |
| 264 | 1 | c 1993 |
| 300 | a 12 s. | |
| 520 | a N-methyl-D-aspartate-receptors are implicated in several neuropathological conditions including epilepsy. As a model of complex partial seizures, rapid hippocampal kindling was chosen to investigate changes in the expression of messenger RNAs encoding the N-methyl-D-aspartate-receptor subunits NR1, NR2A and NR2B both during and in the period immediately following the induction of the kindled state. The study demonstrates a cell-specific, time-dependent modulation of the N-methyl-D-aspartate-receptor subunit messenger RNAs almost entirely restricted to the granule cells of the dentate gyrus. In partially kindled animals (10 stimulations), while the NR1 subunit messenger RNA remained unaltered after a period of 2 h, the NR2A and NR2B subunit messenger RNAs were bilaterally reduced in dentate gyrus granule cells by around 50% below control values. In fully kindled animals (40 stimulations), a progressive reduction in NR1 subunit messenger RNA levels in the dentate gyrus was observed, being maximal after 4 h (-67%). At the same time point, NR2A and NR2B transcript levels were transiently increased by 102% and 46% above control values, respectively. These data point to a differential regulation of N-methyl-D-aspartate-receptor subunit messenger RNAs. No alterations were detected in pyramidal cells. Long-term maintenance of the kindled state was not associated with alterations in N-methyl-D-aspartate-receptor subunit messenger RNAs since control levels of messenger RNA were attained by 12 h and persisted for at least five days. The early changes in messenger RNAs described in this study indicate that the expression of N-methyl-D-aspartate-receptor subunits is under independent regulatory control. This phenomenon may contribute to epileptogenesis and to kindling-associated plasticity by mediating a structural reorganization of N-methyl-D-aspartate-receptors, leading to an altered excitability of dentate gyrus granule cells. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Animals | |
| 653 | a Autoradiography | |
| 653 | a Down-Regulation/physiology | |
| 653 | a Epilepsy/metabolism | |
| 653 | a Hippocampus/anatomy & histology | |
| 653 | a In Situ Hybridization | |
| 653 | a Kindling, Neurologic | |
| 653 | a Male | |
| 653 | a Oligonucleotide Probes | |
| 653 | a RNA, Messenger/biosynthesis | |
| 653 | a Rats | |
| 653 | a Rats, Sprague-Dawley | |
| 653 | a Receptors, N-Methyl-D-Aspartate/metabolism | |
| 700 | 1 | a Kokaia, Mu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-mko |
| 700 | 1 | a Bengzon, Ju Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurokirurgi,Institutionen för kliniska vetenskaper, Lund,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurosurgery,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)neur-jbe |
| 700 | 1 | a Kokaia, Zu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-zko |
| 700 | 1 | a Fritschy, J Mu University of Zurich4 aut |
| 700 | 1 | a Möhler, Hu University of Zurich4 aut |
| 700 | 1 | a Lindvall, Ou Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-oli |
| 710 | 2 | a University of Zurichb Neurologi, Lund4 org |
| 773 | 0 | t Neuroscienceg 57:2, s. 18-307q 57:2<18-307x 0306-4522 |
| 856 | 4 | u http://dx.doi.org/10.1016/0306-4522(93)90064-My FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/dccfa3fd-dc30-4e08-8773-fedc664b9f41 |
| 856 | 4 8 | u https://doi.org/10.1016/0306-4522(93)90064-M |
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