WFRF:(Kristoffersen Wiberg M.)
Sökning: WFRF:(Kristoffersen Wiberg M.) > The neural correlat...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04345naa a2200613 4500 | |
| 001 | oai:gup.ub.gu.se/181131 | |
| 003 | SwePub | |
| 008 | 240528s2013 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:126886773 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1811312 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1601-5215.2012.00659.x2 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1268867732 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Liberg, B.u Karolinska Institutet4 aut |
| 245 | 1 0 | a The neural correlates of self-paced finger tapping in bipolar depression with motor retardation |
| 264 | c 2013-02-22 | |
| 264 | 1 | b Cambridge University Press (CUP),c 2013 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Objective: Motor retardation is a characteristic feature of bipolar depression, and is also a core feature of Parkinson's disease. Within the framework of the functional deafferentiation theory in Parkinson's disease, we hypothesised that motor retardation in bipolar depression is mediated by disrupted subcortical activation, leading to decreased activation of cortical motor areas during finger tapping. Methods: We used functional magnetic resonance imaging to investigate neural activity during self-paced finger tapping to elucidate whether brain regions that mediate preparation, control and execution of movement are activated differently in subjects with bipolar depression (n = 9) compared to healthy controls (n = 12). Results: An uncorrected whole-brain analysis revealed significant group differences in dorsolateral and ventromedial prefrontal cortex. Corrected analyses showed non-significant differences in patients compared to controls: decreased and less widespread activation of the left putamen and left pallidum; increased activity in the left thalamus and supplementary motor area; decreased activation in the left lateral pre- and primary motor cortices; absence of activation in the pre-supplementary motor area; activation of the bilateral rostral cingulate motor area. Conclusion: Both movement preparation and execution may be affected in motor retardation, and the activity in the whole left-side motor circuit is altered during self-initiated motor performance in bipolar depression. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a magnetic resonance imaging | |
| 653 | a mood disorder | |
| 653 | a Parkinson disease | |
| 653 | a psychomotor performance | |
| 653 | a positron-emission-tomography | |
| 653 | a cerebral blood-flow | |
| 653 | a parkinsons-disease | |
| 653 | a psychomotor retardation | |
| 653 | a unipolar depression | |
| 653 | a circuit disorders | |
| 653 | a functional mri | |
| 653 | a basal ganglia | |
| 653 | a brain images | |
| 653 | a fmri | |
| 700 | 1 | a Adler, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Jonsson, T.u Karolinska Institutet4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Rahm, C.u Karolinska Institutet4 aut |
| 700 | 1 | a Wahlund, L. O.u Karolinska Institutet4 aut |
| 700 | 1 | a Kristoffersen-Wiberg, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Wahlund, B.4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t Acta Neuropsychiatricad : Cambridge University Press (CUP)g 25:1, s. 43-51q 25:1<43-51x 0924-2708x 1601-5215 |
| 856 | 4 | u https://gup.ub.gu.se/publication/181131x primaryx freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/181131 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1601-5215.2012.00659.x |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126886773 |
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