Did Viruses Evolve As a Distinct Supergroup from Common Ancestors of Cells?

Harish, AjithUppsala University,Lund University,Lunds universitet,Uppsala universitet,Struktur- och molekylärbiologi,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science (författare)

The evolutionary origins of viruses according to marker gene phylogenies, as well as their relationships to the ancestors of host cells remains unclear. In a recent article Nasir and Caetano-Anolles reported that their genome-scale phylogenetic analyses based on genomic composition of protein structural-domains identify an ancient origin of the "viral supergroup" (Nasir et al. 2015. A phylogenomic data-driven exploration of viral origins and evolution. Sci Adv. 1(8):e1500527.). It suggests that viruses and host cells evolved independently from a universal common ancestor. Examination of their data and phylogenetic methods indicates that systematic errors likely affected the results. Reanalysis of the data with additional tests shows that small-genome attraction artifacts distort their phylogenomic analyses, particularly the location of the root of the phylogenetic tree of life that is central to their conclusions. These new results indicate that their suggestion of a distinct ancestry of the viral supergroup is not well supported by the evidence.

NATURVETENSKAP Biologi Evolutionsbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Evolutionary Biology hsv//eng
NATURVETENSKAP Biologi Bioinformatik och systembiologi hsv//swe
NATURAL SCIENCES Biological Sciences Bioinformatics and Systems Biology hsv//eng
tree of life
origins of viruses
systematic error
rooting artifact
small genome attraction
homoplasy
Homoplasy
Origins of viruses
Rooting artifact
Small genome attraction
Systematic error
Tree of life

Abroi, AareEstonian Bioctr, Riia 23, EE-51010 Tartu, Estonia.,Estonian Biocentre (författare)
Gough, JulianUniv Bristol, Computat Genom Grp, Dept Comp Sci, Merchant Venturers Bldg, Bristol BS8 1TH, Avon, England.,University of Bristol (författare)
Kurland, CharlesLund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science(Swepub:lu)mbio-cku (författare)
Uppsala universitetStruktur- och molekylärbiologi (creator_code:org_t)

Ingår i:Genome Biology and Evolution: Oxford University Press (OUP)8:8, s. 2474-24811759-6653

Av författaren/redakt...: Harish, Ajith; Abroi, Aare; Gough, Julian; Kurland, Charles

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