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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008610naa a2200613 4500
001oai:DiVA.org:oru-113972
003SwePub
008240529s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1139722 URI
0247 a https://doi.org/10.1073/pnas.23153631212 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Andrabi, Syed Bilal Ahmadu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
2451 0a Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA
264 1b Proceedings of the National Academy of Sciences (PNAS),c 2024
338 a print2 rdacarrier
520 a Regulatory T cells (Tregs) are central in controlling immune responses, and dysregulation of their function can lead to autoimmune disorders or cancer. Despite extensive studies on Tregs, the basis of epigenetic regulation of human Treg development and function is incompletely understood. Long intergenic noncoding RNAs (lincRNA)s are important for shaping and maintaining the epigenetic landscape in different cell types. In this study, we identified a gene on the chromosome 6p25.3 locus, encoding a lincRNA, that was up-regulated during early differentiation of human Tregs. The lincRNA regulated the expression of interleukin-2 receptor alpha (IL2RA), and we named it the lincRNA regulator of IL2RA (LIRIL2R). Through transcriptomics, epigenomics, and proteomics analysis of LIRIL2R-deficient Tregs, coupled with global profiling of LIRIL2R binding sites using chromatin isolation by RNA purification, followed by sequencing, we identified IL2RA as a target of LIRIL2R. This nuclear lincRNA binds upstream of the IL2RA locus and regulates its epigenetic landscape and transcription. CRISPR-mediated deletion of the LIRIL2R-bound region at the IL2RA locus resulted in reduced IL2RA expression. Notably, LIRIL2R deficiency led to reduced expression of Treg-signature genes (e.g., FOXP3, CTLA4, and PDCD1), upregulation of genes associated with effector T cells (e.g., SATB1 and GATA3), and loss of Treg-mediated suppression.
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
653 a FOXP3
653 a IL2RA
653 a LIRIL2R
653 a long noncoding RNA
653 a regulatory T cells
7001 a Kalim, Ubaid Ullahu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Palani, Senthilu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Khan, Mohd Moinu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Khan, Meraj Hasanu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Fagersund, Jimmyu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Orpana, Juliusu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Paulin, Niklasu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Batkulwar, Kedaru Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Junttila, Siniu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Buchacher, Tanjau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Grönroos, Toniu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Toikka, Leau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Ammunet, Teau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Sen, Parthou Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Oresic, Matej,d 1967-u Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut0 (Swepub:oru)moc
7001 a Kumpulainen, Venlau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Tuomisto, Johanna E. E.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Sinha, Rahulu Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA4 aut
7001 a Marson, Alexanderu Gladstone-University of California San Francisco Institute of Genomic Immunology, San Francisco, CA, USA4 aut
7001 a Rasool, Omidu Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland4 aut
7001 a Elo, Laura L.u Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland4 aut
7001 a Lahesmaa, Riittau Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finland; Institute of Biomedicine, University of Turku, 20520 Turku, Finland4 aut
7102 a Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland; InFLAMES - Innovation Ecosystem Based on the Immune System Flagship University of Turku and Åbo Akademi University, 20520, Turku, Finlandb Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520, Turku, Finland4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciences (PNAS)g 121:23q 121:23x 0027-8424x 1091-6490
8564 u https://doi.org/10.1073/pnas.2315363121y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113972
8564 8u https://doi.org/10.1073/pnas.2315363121

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